Orcinus orca (killer whale): 101282136 Help Entry 101282136         CDS       T05247                                  Symbol NF1 Name (RefSeq) neurofibromin isoform X2   KO K08052   neurofibromin 1 Organism oor  Orcinus orca (killer whale) Pathway oor01521   EGFR tyrosine kinase inhibitor resistance oor04010   MAPK signaling pathway oor04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:oor00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     101282136 (NF1)    04014 Ras signaling pathway     101282136 (NF1)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101282136 (NF1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2 Motif Other DBs NCBI-GeneID:  101282136 NCBI-ProteinID:  XP_004267206 LinkDB All DBs Position 19:complement(3725104..3982100) Genome browser AA seq 2841 aa AA seqDB search MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL REILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQVSIDHEELLRTCTPGTSL RKGKGNSSMDSAAGYSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEAD IRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWE DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI NMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRL LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNT QFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQL VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVS LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVS FEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLN KATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERG LKLMSKVLQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSF ISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTH WSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQI NGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVY IYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLK VFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQ FTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIA LLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAAN EPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKL ITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVAL ASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAA HLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSL PKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMR DIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESC LKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALL EQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGY RHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHR KSLLLTDISMENIPMDTYPIHHGDPSYRTLKENQPWSSPKGSEGYLAASYPPAGQTSPRA RKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYE METQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRI LYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQY QTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTP TSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSA SQVQKQRSAGSFKRNSIKKIV NT seq 8526 nt NT seq  +upstreamnt  +downstreamnt atggccgcgcacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag cttccaataaaaacaggacagcagaacacacataccaaagtcagtaccgaacacaacaag gaatgtcttatcaatatttccaaatacaagttttctttggttataagcggcctcaccact atcttaaagaatgttaacaatatgagaatatttggagaagctgctgaaaaaaatttatat ctctctcagttgattatattggatacactggaaaaatgtcttgctgggcaaccaaaggac acgatgaggttagatgaaacgatgctggtcaaacagttgctgccagaaatctgccatttt cttcatacttgtcgtgagggaaaccaacatgcagctgaacttcggaattctgcctctggg gttttattttctctcagctgcaacaacttcaatgcagtctttagtcgaatttctaccagg ttacaggaattgactgtttgttcagaagacaatgttgatgttcatgatatagaattgtta cagtatatcaatgtggattgtgcaaaattaaaacgactcctgaaggaaacagcatttaaa tttaaagccctaaagaaagttgcacaattagcggttataaatagcctggaaaaggcattt tggaactgggtagaaaattatccagatgaatttacaaagttataccagattccacagact gatatggctgagtgtgcagaaaaactctttgacctagtggatggttttgctgaaagcacc aaacgtaaagcagcagtttggccactacaaatcattctccttatcttgtgtccagaaata atccaggatatatccaaggatgtggttgatgaaaacaacatgaataagaagttgtttctg gacagtctacgaaaagcacttgccggccacggaggaagcaggcagctgactgaaagcgct gcaattgcctgtgtcaaactgtgtaaagcaagtacttacatcaattgggaagataactct gtcatcttcttactagttcagtccatggtggttgatcttaagaacctgctttttaatcca agtaaaccattctcaagaggcagtcagcctgcagatgtggatctaatgattgactgcctt gtttcttgctttcgtataagccctcacaacaaccaacactttaagatctgtctggctcag aattccccttctacatttcactatgtgctggtaaattcactccatcgaatcatcaccaat tctgcattggattggtggcctaagattgatgccgtatattgtcactcagttgaacttcga aatatgtttggtgaaacacttcataaagcagtccagggttgtggagcgcacccagcgata cgaatggcaccgagtcttacatttaaagaaaaagtaacaagccttaaatttaaagaaaaa cctacagacctggagacaagaagctataagtatcttctcttgtccatggtgaaactaatt catgcagatccaaagctcttgctttgtaatccgagaaaacaggggcctgaaactcaaggc agtaccgcagaattaattacagggctcgtccaactggtacctcagtcacacatgccagag attgctcaggaagcaatggaggctctgttggttcttcatcagttagatagcattgatttg tggaatcctgatgctcctgtagaaacattttgggaaatcagctcacaaatgcttttttac atctgcaagaaattaactagccatcaaatgcttagtagcacagaaattctcaaatggttg cgggaaattttgatctgcaggaataaatttcttcttaaaaataagcaggcagatagaagt tcctgtcactttctcttcctttatggagtaggatgtgatgttccttcaagtggaaatacc agtcaggtgtccatagatcatgaagaattactacgtacttgtactcctggaacctctctc cgaaagggaaaaggaaattcatccatggatagtgcagcagggtacagcggaaccccgcca atatgccgacaagcccagaccaaactagaagtggccctgtacatgtttctgtggagccct gacactgaagctgttctggttgccatgtcctgttttcgtcacctctgtgaggaagcggat atccggtgtggggtggatgaagtgtcagtgcacaacttcttgcccaactataacacattc atggagtttgcctctgtcagcaatatgatgtcaacaggaagagcagcacttcagaaaaga gtgatggcattactacggcgaattgagcatcccaccgcaggaaacactgaggcttgggaa gatacacatgcaaagtgggaacaagctacaaaactaatcctcaactacccaaaagccaaa atggaagatggccaggctgctgaaagccttcacaagaccatcgttaagaggcgaatgtct catgtgagtggaggaggatccatagatttgtctgacacagactccctacaagaatggatc aacatgactggcttcctttgtgcccttgggggagtatgcctgcagcagagaagcaattct ggcctggcaacctatagcccacccatgggcccagtcagtgaacgcaagggttccatgatt tcagtgatgtcctcagagggaaacgcagatacacctgtcagcaaatttatggatcgattg ctatccttaatggtctgtaaccatgagaaagtgggacttcagatacggaccaatgttaag gatctggtgggtctagaattgagtcctgctctttatccaatgctgtttaacaaactgaag aataccatcagcaagttttttgactcccaagggcaggttttattgactgacaccaatact cagttcgtggagcaaaccatagctataatgaagaacttactagataatcatactgaaggc agctctgaacatctggggcaagctagcattgaaacaatgatgttaaatctggtcagatat gttcgtgtgcttgggaatatggtccatgcaattcaaataaaaacgaaactgtgtcagtta gtggaggtaatgatggcaaggagagacgacctctcattttgtcaagagatgaaatttagg aataagatggtagaatacctgacagattgggttatgggaacatcaaaccaagcagcagat gatgatgtcaaatgtcttacaagagatttggaccaggcaagcatggaagcagtagtttca ctcctggctggtcttccgctgcagcctgaggaaggagatggtgtggaattgatggaagcc aaatcacagttatttcttaagtatttcacattgtttatgaaccttttgaacgactgtagt gaagttgaagatgaaaatgcacaaacaggtggcaggaaacgtggcatgtctcggaggctg gcatcactgaggcactgtacagtcctggcaatgtcaaacttactcaatgctaacgtggac agtggcctcatgcactccataggtttaggttatcacaaagatcttcagacaagagctaca tttatggaagttctgacaaaaatccttcaacaaggcacagaatttgacacacttgcagaa accgtgttggcagatcgttttgagagactggtagagttggtcacaatgatgggtgatcaa ggagagctcccaatagctatggctctggccaatgtggtcccttgttctcagtgggatgaa ctagctcgagttctagtgactctatttgactctcggcatttactctaccaactgctctgg aacatgttttctaaggaagtagaattggcagactccatgcagactctcttccgaggcaac agcttggccagtaaaataatgaccttctgtttcaaggtatatggtgctacctacctacag aaactcctggatcctttattacggattgtgatcacatcctctgattggcagcatgttagc tttgaagtagatcctaccaggttagaacagtcagagagccttgaggaaaaccagcgaaac ctccttcagatgaccgaaaagttcttccatgccatcatcagttcctcctccgaatttccc cctcagctacgaagtgtgtgccactgtttgtaccaggcaacttgccactccctactgaat aaagctacagtaaaagaaaaaaaggaaaacaaaaaatcagtggttagccagcgtttccct cagaacagcatcggtgcagtgggaagtgccatgtttctcagatttatcaatcctgccatt gtctcaccatatgaagcagggattctagataaaaagccgccacctagaatcgaaaggggc ttgaagttaatgtcaaaggtacttcagagtattgccaatcatgtccttttcacaaaagaa gagcacatgcggccttttaatgattttgtgaaaagcaactttgatgcagcacgaaggttt ttccttgatatagcatccgattgtcctacaagtgatgcagtaaatcacagtctttccttc atcagtgatggcaatgtgcttgctttacatcgtctactctggaacaatcaagagaaaatt ggccagtatctttccagcaacagggatcacaaagctgttggaagacgaccttttgataag atggcaacacttcttgcatacctgggtcctccagagcacaaacctgtggcagatacacac tggtccagccttaaccttaccagttcaaagtttgaggaatttatgacgaggcatcaagta catgaaaaagaagagttcaaagctttgaaaactttgagtattttctaccaagctgggact tccaaagctgggaatcctatattttattatgttgcacggaggttcaaaactggtcaaatc aatggcgatttgctgatataccacgtcttacttactttaaagccatattatgcaaagcca tatgaaattgtagtggaccttacccatactgggcctagcaatcgctttaaaacagacttt ctctccaagtggtttgttgtttttcctggctttgcttatgataatgtctctgcagtctat atctataactgtaactcctgggtcagggaatacaccaagtatcacgagcggctgctgact ggcctcaaaggcagcaaaagactcattttcatagactgtcctgggaaactggccgagcac attgagcatgaacaacagaaactacctgctgccaccttggctttagaagaggacctgaag gtattccacaatgctctcaagctggctcacaaagacaccaaggtttctattaaagttggt tctactgctgttcaagtaacctcagcagagcgaacaaaagtcctggggcagtcagtcttt ctaaatgatatctattatgcttcggaaattgaagagatctgcctagtggatgagaaccag ttcaccttaactattgcaaaccagggcacaccactgaccttcatgcaccaagagtgtgaa gccattgttcagtctatcattcacatccggacacgttgggagctgtcgcagcctgactcc atcccccagcacaccaagattcgcccaaaagatgtccctgggacactgctcaatatcgca ttacttaatttaggcagttcagaccctagtttacggtcagctgcctataatcttctgtgt gccttaacttgtacctttaatttaaaaatcgagggccagttactagagacatcaggttta tgtatcccagccaacaacaccctatttattgtctctattagcaagacactggcagccaat gagccacacctcaccttagaatttttggaagagtgtatttctggatttagcaaatctagt attgaattgaaacacctttgtttggaatacatgactccgtggctgtcaaatctagtacgt ttttgtaagcacaatgatgatgccaaaagacaaagagtgactgcgattcttgataagctg ataacaatgactataaacgagaaacagatgtatccatctattcaagcaaaaatatggggg agccttgggcagattacagacctccttgatgttgtcctagacagtttcatcaaaaccagt gcaacgggtggcttgggatcaataaaagctgaggtgatggcagatactgctgtagctttg gcttctggaaatgtgaaattggtttcaagcaaggttattggaaggatgtgcaaaataatt gacaagacatgcttatctccaactcctactttagagcaacatcttatgtgggacgatatt gctattctagcccgctacatgctgatgctgtccttcaacaattccctggatgtggcagct catctcccctacctcttccacgtcgttactttcttagtagccacagggccactctccctt agagcttccacacatggattggtcattaatatcattcactctctgtgtacttgttctcag cttcattttagtgaagagaccaagcaagttttgagactcagtttgacagagttctcatta cccaaattttacctgctgtttggcattagcaaagtcaagtcagctgctgtcattgccttc cgctccagctaccgggacaggtcattctctcctggctcctatgagagggagacttttgct ttgacatccttggaaacagtcacagaagctttgttggagatcatggaggcatgtatgaga gatattccaacatgcaagtggctggaccagtggacagaactagctcaaagatttgcgttc cagtataatccatccctgcaacctagagcccttgttgtcttcggctgtatcagcaaacgg gtgtctcatgggcagataaagcagattatccggatcctcagcaaggcgcttgagagttgc ttaaaaggacctgatacttacaacagtcaagttctgatagaagctacagtaatagcacta accaagttacaaccacttcttaataaggactcccctctgcataaagccctcttttgggta gctgtggccgtgctgcagctcgatgaagtcaacttgtattcagcgggcaccgcacttctg gaacaaaacctgcacaccttagacagtctccggatattcaatgacaagagtccagaggaa gtattcatggcgatccggaatcctctggaatggcactgcaaacaaatggatcattttgtt ggactcaatttcaactctaactttaacttcgcactggttggacacctcttaaaaggatac aggcatccttcacctgccattgttgcaagaacagtcagaattttgcatacactactaact ctggttaataaacatagaaattgtgacaaatttgaggtgaatacacagagcgtggcttac ttggcagctttacttacagtgtctgaggaggttcgaagtcgctgtagcctaaaacataga aagtctcttcttcttactgatatttcaatggaaaatattcctatggatacatatcccatt catcacggtgaccctagctataggacactaaaggagaatcagccatggtcctctcccaaa ggttctgaagggtacctcgcagccagctatccacctgcgggccagaccagtccccgagcc aggaaatccatgagtttggacatggggcagccttctcaggccaacacgaagaagttgctt ggaacaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaaggcaagaa atggaatcagggatcacaacaccccccaaaatgaggagagtagcagaaactgattatgaa atggaaactcaaaggatttcctcatcacaacagcacccacatttacgtaaagtttcagtg tctgaatcaaatgttctcttagatgaggaagtacttactgatccgaagatccaagcactt cttcttactgttctggctacgctggtgaaatacaccacagatgagtttgatcaacgaatt ctttatgaatacttagcagaagctagtgttgttttccccaaagtttttcctgttgtgcac aatttgttggactctaagatcaacaccctgttgtcattgtgccaagatccaaatttgtta aatccaatccatgggattgtgcaaagtgtggtgtaccatgaagaatccccaccacagtac caaacatcttacctgcaaagttttggttttaatggcctatggcggtttgcaggacccttt tcaaagcaaacacaaatcccagactatgctgagcttattgttaagtttcttgatgccttg attgacacgtatttgcctggaattgatgaagaaaccagtgaggagtccctcctgacaccc acatctccttatcctcctgcagtgcagagccagcttagtattactgctaaccttaacctt tctaattccatgacctcacttgcaacttcccagcattccccaggaatcgacaaggagaat gttgaactctcccctaccactgggcactgtaacagtgggcgaactcgtcatggatccgca agccaggtgcagaagcaaagaagcgctggcagtttcaaacgtaatagcattaagaagatc gtgtga

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