Orcinus orca (killer whale): 101285238
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Entry
101285238 CDS
T05247
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3 isoform X2
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor00230
Purine metabolism
oor00670
One carbon pool by folate
oor01100
Metabolic pathways
oor01523
Antifolate resistance
Module
oor_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
101285238 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
101285238 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
101285238 (GART)
Enzymes [BR:
oor01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
101285238 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
101285238 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
101285238 (GART)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_3
CPSase_L_D2
ATP-grasp_2
ATP-grasp_4
Dala_Dala_lig_C
LUD_dom
DUF3104
SNF5
Motif
Other DBs
NCBI-GeneID:
101285238
NCBI-ProteinID:
XP_004264574
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All DBs
Position
5:complement(137731033..137758808)
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AA seq
1010 aa
AA seq
DB search
MAARVLVIGNGGREHTLAWKLAQSNHVKQVLVTPGNAGTACSEKISNTDISISDHTALAQ
FCKNEKIEFVVVGPEAPLAAGIVGSLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TAQWRAFTKAEEACCFIMSADFPALVVKASGLAAGKGVVVAKSKEEACKAVQEIMQDKAF
GEAGETTVIEELLEGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDQGPNTGGMGAYCPAP
QVSKDLLLKIKNTILQKTVDGMQQEGVPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLDNRTAVTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFQAGTALKDGKVVTNGGRVLTVTAIRENLISALEEAKKGLAAIKFEGAIYRKD
IGYRAIAFLQQPRGLTYKDSGVDIAAGNMLVKKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFNDPLLACGTDGVGTKLKIAQQCHKHETIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDPSAAEAVVAGIAKACKKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDAVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGGQALGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPQKFGVDLDAQTWRIPRIFSWLQQEG
HLSEEEMARTFNCGIGAALVVSKDLTQQILQDIQQHKEEAWVIGRVVACPEGSPRVKVKH
LIETMQINRSVLENGTLKNHVSVQPKKARVAVLISGTGSNLQALIDSTREPSSSAHIVVV
ISNKAAVSGLDKAERAGIPTRVINHKLYKNRAAFDTTVDQVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLDAGVTITGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVETLSERVKLAEHKIFPSALQLVASGTVRLGENGKICWVKEE
NT seq
3033 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgagtacttgtaattggcaatggaggaagggaacatactctggcctggaaa
cttgcacagtctaatcatgtcaaacaagtgttagttaccccaggaaatgcaggcactgcc
tgctctgaaaagatttcgaacactgacatctcaatcagtgatcacactgcccttgcacag
ttctgcaaaaatgagaaaattgaatttgtagttgttggaccagaggcacctctggctgct
ggaattgttgggagcctgacatctgcaggagtgcggtgctttggccccacagcagaagca
gctcagttagagtccagcaagaggtttgccaaagagtttatggaccgacatggaatccca
actgcacagtggagagctttcaccaaagctgaagaagcctgctgcttcattatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctgggaaaggggtagttgtc
gcaaagagcaaagaagaggcctgcaaagctgtacaggagattatgcaggataaagctttt
ggagaagctggagaaacaactgtcattgaagaacttcttgaaggagaagaggtgtcttgt
ctgtgcttcactgatggaaagactgtggcccccatgcccccagcacaggaccataagcga
ttgctggagggagatcagggccccaacacagggggaatgggagcctattgtccagcacct
caggtttctaaggatttgttgctaaaaattaaaaatactattcttcagaagacagtggat
ggcatgcagcaggagggtgtgccatacacaggtatcctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagtttaattgccgttttggtgatccagagtgccaagtg
atcctcccacttcttaaaagtgacctttatgaagtgattcagtctaccttagatggcctg
ctctgcacatctctgcctgtttggcttgacaaccgcactgccgtaactgtggtcatggca
agtaaaggttatccaggagactacaccaagggtgtagagataacagggtttcctgaggct
caagctttaggactagaggtgtttcaagcaggcactgccctaaaagatggcaaagtggtg
actaacgggggtagggtccttacagtaacggccatccgggaaaatctcatctcagccctt
gaagaagccaagaaaggactagctgctataaagtttgagggggccatttataggaaggac
attggctatcgtgccatagctttcctccagcagcccaggggcctgacttacaaggactct
ggggtagatattgcagctggaaatatgctggtcaagaaaattaagcctttagcaaaagcc
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagccggtttcaacgatcctcttctggcctgtggaacagacggcgttggaactaaactg
aagattgcccagcagtgccataaacatgaaaccattggtcaagatttggttgcgatgtgt
gtaaatgatattctggcacaaggagcggagcccctctttttcctcgattacttttcctgt
ggaaaacttgaccccagtgcagctgaagctgttgttgctggaattgctaaagcttgtaaa
aaagccggatgtgctctcctcggaggtgaaacggcagaaatgcctgacatgtaccctcct
ggagagtatgatctagccggttttgccgttggtgcaatggagcgggatcagaaactccct
cacctggaaagaatcactgaaggggacgctgttattggaatagcttcatctggtcttcac
agcaatggatttagccttgtgaggaaaattgtagcgaaatcttcccttcagtactcctct
ccagcacctgatggctgtggtggccaggccttaggtgatttacttctaactccaaccaga
atctacagccattcactgttacctgtcctgcgttcaggacatgttaaggcctttgcacat
attaccggtgggggattgctagaaaacatccccagagtcctacctcagaaatttggggtg
gatttagatgcccagacctggaggatccccaggatcttctcgtggttacagcaggaagga
cacctctctgaagaagagatggccagaacatttaactgtgggattggggctgccctcgtg
gtatcaaaggatctgacacagcagattctgcaggatattcagcagcacaaggaagaagcc
tgggtgatcggcagagtggttgcatgtcctgaaggttctcctcgtgtgaaagtcaagcat
ctgattgaaaccatgcaaataaatagatcagtattggagaatggcaccctgaaaaatcat
gtctctgttcaaccaaaaaaggcaagagtagctgtcttaatatctgggacaggatcaaac
ctccaagctctcatagacagtactagggagccaagtagctctgcacacattgttgttgtg
atctccaacaaagctgcagtgtctggcttagataaagcagaaagagccggaattcccacc
agggtaattaatcataaattatataaaaatcgtgcagcatttgacactacagtagaccaa
gtccttgaagagttctccacagacatagtctgtcttgcaggattcatgagaattttatct
ggcccctttgtcagaaaatggaatgggaaaatgctcaacatccacccatccttgctccct
tcgtttaagggttcaaatgcccatgaacaagtcctggatgccggggtcaccatcactggg
tgcaccgtgcactttgtagctgaagatgtagatgctggacaaattattttacaagaagct
gttccggtgaagaggggtgacactgttgaaactctatctgaaagagtaaaattagcagaa
cataaaatatttccctcagccctccagctggtggccagtggaactgtacggcttggagaa
aatggcaagatctgttgggtcaaagaggaatga
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