KEGG   Odobenus rosmarus divergens (Pacific walrus): 101365730
Entry
101365730         CDS       T05148                                 
Symbol
MET
Name
(RefSeq) hepatocyte growth factor receptor
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
oro  Odobenus rosmarus divergens (Pacific walrus)
Pathway
oro01521  EGFR tyrosine kinase inhibitor resistance
oro04010  MAPK signaling pathway
oro04014  Ras signaling pathway
oro04015  Rap1 signaling pathway
oro04020  Calcium signaling pathway
oro04151  PI3K-Akt signaling pathway
oro04360  Axon guidance
oro04510  Focal adhesion
oro04520  Adherens junction
oro05100  Bacterial invasion of epithelial cells
oro05144  Malaria
oro05200  Pathways in cancer
oro05202  Transcriptional misregulation in cancer
oro05205  Proteoglycans in cancer
oro05206  MicroRNAs in cancer
oro05208  Chemical carcinogenesis - reactive oxygen species
oro05211  Renal cell carcinoma
oro05218  Melanoma
oro05223  Non-small cell lung cancer
oro05225  Hepatocellular carcinoma
oro05226  Gastric cancer
oro05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:oro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101365730 (MET)
   04014 Ras signaling pathway
    101365730 (MET)
   04015 Rap1 signaling pathway
    101365730 (MET)
   04020 Calcium signaling pathway
    101365730 (MET)
   04151 PI3K-Akt signaling pathway
    101365730 (MET)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101365730 (MET)
   04520 Adherens junction
    101365730 (MET)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    101365730 (MET)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101365730 (MET)
   05202 Transcriptional misregulation in cancer
    101365730 (MET)
   05206 MicroRNAs in cancer
    101365730 (MET)
   05205 Proteoglycans in cancer
    101365730 (MET)
   05208 Chemical carcinogenesis - reactive oxygen species
    101365730 (MET)
   05230 Central carbon metabolism in cancer
    101365730 (MET)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101365730 (MET)
   05226 Gastric cancer
    101365730 (MET)
   05218 Melanoma
    101365730 (MET)
   05211 Renal cell carcinoma
    101365730 (MET)
   05223 Non-small cell lung cancer
    101365730 (MET)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    101365730 (MET)
  09174 Infectious disease: parasitic
   05144 Malaria
    101365730 (MET)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101365730 (MET)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oro01001]
    101365730 (MET)
Enzymes [BR:oro01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     101365730 (MET)
Protein kinases [BR:oro01001]
 Receptor tyrosine kinases (RTK)
  MET family
   101365730 (MET)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr TIG Pkinase Sema PSI Kinase-like Pkinase_fungal Linker_histone PepSY_TM
Other DBs
NCBI-GeneID: 101365730
NCBI-ProteinID: XP_004408545
UniProt: A0A2U3WIC3
LinkDB
Position
Unknown
AA seq 1382 aa
MKAPAVFAPGILVLLFTLVQKSYGECKEALVKSEMNVNMKYQLPNFTAETSIQNVVLHKH
HIYLGAVNYIYVLNDKDLQKVAEYKTGPVLEHPDCFPCQDCSHKANLSGGIWEDNINMAL
LIDTYYDDQLISCGSVHRGTCQRHVLPPSNTADIQSEVHCMYSPQADEEPGQCPDCVVSA
LGTKVLISEKDRFINFFVGNTINSSYHPDHSLHSISVRRLKETQDGFKFLTDQSYIDVLP
EFRDSYPIKYVQAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECI
LTEKRRKRSTREEVFNILQAAYVSKPGAHLAKQIGANLNDDILYGVFAQSKPDSAEPMNR
SAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRSDEYRTE
FTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSGGRFMQVVVSRSGSSTPHVNF
RLDSHPVSPEAIVEHPLNQNGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPPFVQCG
WCHNKCVQLEECPTGTWTQEICLPTIYEVFPTSVPLEGGTMLTICGWDFGFRRNNKFDLK
KTRVLLGNESCTLTLSESTTNMLKCTVGPAVNEHFNISIIIANGRGTAQYNTFSYVDPII
TSISPSYGPKTGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTPTE
FPIKLKIDLANREMNSFSYQEDPIVYEIHPTKSFISGGSTITAVGKNLHSVSVLRMVINV
QEARRNFTVACQHRSSSEIICCTTPSLQQLNLHLPLKTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCETIYLDSEAVLCKVPND
LLKLNNELNIEWKQAVSSTVLGKVIVQPDQNFTGLIVGVISISLIVLLLLGLFLWLKRRK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTAEMVSNESVDYRATFPEDQFPNSSQNG
SCRQVQYPLTDLSPMLTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK
FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC
WHPKAELRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNIDGEG
DT
NT seq 4149 nt   +upstreamnt  +downstreamnt
atgaaggcccctgctgtgtttgcacctggcatccttgtgcttctatttaccttggtgcag
aagagctatggggagtgcaaagaggcactagtaaagtctgagatgaatgtgaacatgaag
tatcagcttcccaacttcactgcagaaacatccatccagaatgttgttttacacaagcat
catatttaccttggcgcagttaactatatttatgttttaaatgacaaagatcttcagaag
gttgctgagtacaagactgggcccgtgctggaacacccagattgtttcccatgtcaggac
tgcagccacaaagccaatttatcaggtggcatttgggaagataacatcaacatggctcta
cttattgacacatactatgatgaccaactcattagttgtggcagtgtccacagagggacc
tgccagcgacatgtccttccacccagcaatactgctgacatacagtcggaagttcactgc
atgtactccccacaggcagacgaagagcctggccagtgccctgactgtgtggtgagtgcc
ctgggaaccaaagtcctgatatctgaaaaggatcggttcatcaacttcttcgtgggcaat
accataaattcctcgtaccatccagatcattcattgcattcgatatcagtgagaaggcta
aaggaaacgcaagatggtttcaagtttttgacagaccagtcttatattgacgttctacct
gagttcagagattcctaccctattaaatatgtccaagcctttgaaagcaatcattttatt
tactttttgacagtccaacgagaaactctagatgctcagacttttcacacaagaataatc
aggttctgttctgtagactctggattgcattcctacatggaaatgcctctggagtgtatt
ctcacggaaaaaagaagaaagagatccaccagggaggaagtatttaatattctccaagct
gcatatgtcagtaagcctggggcccaccttgctaagcaaataggtgctaacctgaatgat
gacattctctatggagtgtttgcacaaagcaagccagattctgctgaaccaatgaatcgc
tctgctgtctgtgcattccctatcaaatatgtcaatgaattcttcaacaagatcgtcaac
aaaaacaatgtgagatgtcttcaacatttttatggacccaaccacgaacactgctttaat
aggacacttttgagaaattcatcaggctgtgaagtgcgcagtgatgaatatcgaacagag
tttactacagctttgcagcgtgttgacttattcatgggccaattcaaccaagtcctctta
acatctatatctaccttcattaaaggagacctcaccattgctaatcttgggacgtcaggg
ggtcgcttcatgcaggtcgtggtttctcgatcaggatcatcaacccctcatgtgaatttt
cgcctggattcccaccctgtgtctccagaagcaattgtggagcacccattaaaccaaaat
ggctacacgctggttgtcactgggaagaagatcaccaagatcccactgaatggcttaggc
tgtgaacatttccagtcctgcagtcagtgtctttccgcccctccctttgtgcagtgcggc
tggtgccacaataaatgtgtgcaattagaggaatgccccactggaacatggactcaggag
atctgtctgcctacaatctatgaggttttcccaactagcgtacccttggaaggagggaca
atgctgaccatatgtggctgggacttcggattcaggaggaataataaatttgatttaaag
aaaaccagagttctccttggaaatgagagctgcaccttgaccttgagtgagagcacaaca
aatatgctgaaatgcacagttggtcctgcagtgaatgagcatttcaatatatccataatt
attgcaaatggtcgagggacagcacaatataatacattttcctatgtggatcctataata
acaagtatttctccaagttatggtcctaagactggtggcaccttgcttactttaactgga
aagtacctaaacagtgggaattctagacacatttcaattggtggaaaaacatgtacttta
aaaagtgtgtcagatagtattcttgaatgttataccccagctcaaaccactccaactgag
tttcctattaaattgaaaattgacttagccaaccgagagatgaacagcttcagttaccag
gaagaccccattgtctacgaaattcatccaaccaaatcttttattagtggtgggagcaca
ataacagctgttgggaaaaacctgcattcagttagtgtcctgaggatggtcataaatgta
caggaagcgagaaggaactttacagtggcatgtcagcatcgctctagctcagagataatc
tgctgtacaactccttcactgcaacagctgaatctgcacctccctctgaaaaccaaagcc
tttttcatgttagatgggatccattccaaatactttgatctcatttatgtacataatccc
gtgtttaagccttttgaaaagccagtgatgatctcaataggcaatgaaaatgtactggaa
attaagggaaatgatattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaat
aagagctgtgagactatatacttggattctgaagccgttttatgcaaggtccccaatgac
ctgctgaaattgaacaacgagctaaatatagagtggaagcaagcagtttcttcaaccgtc
cttggaaaagtaattgttcagccagatcagaatttcacaggattgattgttggtgttatc
tcaatatcattaatagtcttattattactcgggcttttcctgtggctgaaaaggagaaag
caaattaaagatctgggcagtgaattagttcgctatgatgcaagagtacacactcctcat
ttggataggcttgtaagtgcccgaagtgtaagcccaactgcagaaatggtttcaaatgaa
tctgtagactaccgagctacttttccagaagaccagtttcctaactcatctcagaatgga
tcatgcagacaagtacagtatcctctgacggacctgtcccccatgctcactagtggggac
tctgatatatccagtccattattgcaaaatactgtccacattgacctcagtgctctaaat
ccagagctggtccaggcagtccagcacgtagtgattgggccgagtagcctgattgtgcat
ttcaatgaagtcataggaagaggacattttgggtgtgtataccatgggactttgttggac
aatgatgacaagaaaattcactgtgctgtgaaatccttgaatcgaatcactgacatagga
gaagtttcccagtttctgaccgagggaatcatcatgaaagattttagtcatccaaacgtt
ctctcgctcttgggaatctgccttcgaagtgaggggtctccgctagtggtcctaccatac
atgaaacatggagatcttcgaaatttcattagaaatgagactcataacccaactgtaaaa
gatcttattggctttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaag
tttgtccacagagacttggctgcaagaaactgtatgctggatgagaaattcactgtcaag
gttgctgattttggtcttgccagagacatgtatgataaagaatactatagtgtacacaac
aaaacaggtgccaagctgcccgtgaagtggatggctttagaaagtctgcaaactcagaag
tttaccaccaagtcagatgtgtggtcctttggcgtcctcctctgggaactgatgacaaga
ggagcaccaccttaccctgacgtcaacacctttgatataacagtttacttgttgcaaggc
agaaggctcctacaacccgaatactgcccagatcccttatatgaagtgatgctcaaatgc
tggcaccctaaagctgaactgcgcccatctttttctgaactggtctccaggatatcagca
atattctctactttcattggggagcactacgtccatgtgaacgctacttatgtgaatgtc
aaatgtgttgctccgtacccttctctgttgtcatcacaggataacattgatggcgagggg
gacacatga

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