KEGG   Odobenus rosmarus divergens (Pacific walrus): 101377465
Entry
101377465         CDS       T05148                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
oro  Odobenus rosmarus divergens (Pacific walrus)
Pathway
oro01521  EGFR tyrosine kinase inhibitor resistance
oro01522  Endocrine resistance
oro04010  MAPK signaling pathway
oro04012  ErbB signaling pathway
oro04015  Rap1 signaling pathway
oro04024  cAMP signaling pathway
oro04062  Chemokine signaling pathway
oro04068  FoxO signaling pathway
oro04150  mTOR signaling pathway
oro04270  Vascular smooth muscle contraction
oro04510  Focal adhesion
oro04650  Natural killer cell mediated cytotoxicity
oro04720  Long-term potentiation
oro04722  Neurotrophin signaling pathway
oro04726  Serotonergic synapse
oro04730  Long-term depression
oro04810  Regulation of actin cytoskeleton
oro04910  Insulin signaling pathway
oro04914  Progesterone-mediated oocyte maturation
oro04928  Parathyroid hormone synthesis, secretion and action
oro04934  Cushing syndrome
oro05010  Alzheimer disease
oro05022  Pathways of neurodegeneration - multiple diseases
oro05034  Alcoholism
oro05160  Hepatitis C
oro05161  Hepatitis B
oro05200  Pathways in cancer
oro05205  Proteoglycans in cancer
oro05208  Chemical carcinogenesis - reactive oxygen species
oro05210  Colorectal cancer
oro05211  Renal cell carcinoma
oro05212  Pancreatic cancer
oro05213  Endometrial cancer
oro05214  Glioma
oro05215  Prostate cancer
oro05216  Thyroid cancer
oro05218  Melanoma
oro05219  Bladder cancer
oro05220  Chronic myeloid leukemia
oro05221  Acute myeloid leukemia
oro05223  Non-small cell lung cancer
oro05224  Breast cancer
oro05225  Hepatocellular carcinoma
oro05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:oro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101377465 (BRAF)
   04012 ErbB signaling pathway
    101377465 (BRAF)
   04015 Rap1 signaling pathway
    101377465 (BRAF)
   04068 FoxO signaling pathway
    101377465 (BRAF)
   04024 cAMP signaling pathway
    101377465 (BRAF)
   04150 mTOR signaling pathway
    101377465 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101377465 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101377465 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101377465 (BRAF)
   04062 Chemokine signaling pathway
    101377465 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101377465 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    101377465 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    101377465 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101377465 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    101377465 (BRAF)
   04720 Long-term potentiation
    101377465 (BRAF)
   04730 Long-term depression
    101377465 (BRAF)
   04722 Neurotrophin signaling pathway
    101377465 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101377465 (BRAF)
   05205 Proteoglycans in cancer
    101377465 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    101377465 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101377465 (BRAF)
   05212 Pancreatic cancer
    101377465 (BRAF)
   05225 Hepatocellular carcinoma
    101377465 (BRAF)
   05226 Gastric cancer
    101377465 (BRAF)
   05214 Glioma
    101377465 (BRAF)
   05216 Thyroid cancer
    101377465 (BRAF)
   05221 Acute myeloid leukemia
    101377465 (BRAF)
   05220 Chronic myeloid leukemia
    101377465 (BRAF)
   05218 Melanoma
    101377465 (BRAF)
   05211 Renal cell carcinoma
    101377465 (BRAF)
   05219 Bladder cancer
    101377465 (BRAF)
   05215 Prostate cancer
    101377465 (BRAF)
   05213 Endometrial cancer
    101377465 (BRAF)
   05224 Breast cancer
    101377465 (BRAF)
   05223 Non-small cell lung cancer
    101377465 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101377465 (BRAF)
   05160 Hepatitis C
    101377465 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101377465 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    101377465 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    101377465 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101377465 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101377465 (BRAF)
   01522 Endocrine resistance
    101377465 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oro01001]
    101377465 (BRAF)
Enzymes [BR:oro01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101377465 (BRAF)
Protein kinases [BR:oro01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   101377465 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal
Other DBs
NCBI-GeneID: 101377465
NCBI-ProteinID: XP_012422734
LinkDB
Position
Unknown
AA seq 772 aa
MIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVS
SSASTDTVTSSSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPAR
CGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPL
TTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVS
KFFEHHPIPQEEASIAETALTSGSSPSAPPSDSAGHQILTSPSPSKSIPIPQPFRPADED
HRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRSDGAPLNQLMRCLRKCQSRTPSP
LLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSS
EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIK
LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQ
LSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRG
YLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQERSRRKYRLFNSGYPWKILASIE
LLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2319 nt   +upstreamnt  +downstreamnt
atgattaagttgacacaggaacatatagaagccctgttggacaaatttggtggggagcat
aatccaccatcaatatatctggaggcctatgaagaatacaccagcaagctagatgccctc
caacagcgagaacaacagttattggaatccctggggaatggaactgatttttctgtttct
agctctgcatcaacggacactgttacatcttcttcctcttccagcctttcagtgctacct
tcatctctttcagtttttcaaaatcccacagatgtatcacggagcaatcccaagtcacca
caaaaacctatcgttagagtcttcctgcccaataaacagaggacagtggtacctgcaaga
tgtggagttacagtccgagacagtctaaagaaagctctgatgatgagaggtctaatccca
gagtgctgtgctgtttacagaattcaggatggagagaagaaaccgattggctgggacact
gatatttcctggctcaccggagaggaactgcatgtagaagtgttggaaaatgttccgctt
accacacacaactttgtacggaaaacctttttcaccttagcattttgtgacttttgtcga
aagctgcttttccagggttttcgctgtcaaacatgtggttataaatttcaccagcgctgt
agtacagaggttccactgatgtgtgttaattatgaccaacttgatttgctgtttgtctcc
aagttctttgaacaccacccaataccacaggaggaggcctccatagcagagactgccctt
acgtctggatcatccccttccgctcccccctccgattctgctgggcaccaaattctcacc
agtccgtctccttcaaaatccattccaattccacagcctttccgaccagcagatgaagat
catcgaaatcaatttggacaacgagaccggtcctcatcagctccaaatgtgcatataaac
acaatagaacctgtcaatattgatgacttgattagagaccaagggtttcgtagtgacgga
gcccctttgaaccagctgatgcgctgccttcggaaatgccaatcccggactcccagtccc
ctcctacattctgtccccagtgaaatagtgtttgattttgagcctggcccagtgttcaga
ggatcaaccacaggtttgtctgccaccccccctgcctcattgcctggctcactcactaat
gtaaaagcgttacagaaatctccaggacctcagcgggaaaggaaatcatcttcatcctca
gaagataggaatcgaatgaaaacccttggtagacgggattcaagtgatgattgggagatt
cctgatgggcagatcacagtgggtcagagaattggatctgggtcatttgggacagtctac
aagggaaagtggcatggtgatgtggcagtgaaaatgttgaatgtgacagcacccacacct
cagcagttacaggccttcaaaaatgaagtaggagtactcaggaaaactcgacatgtgaat
atcctactcttcatgggctattcaacaaagccccaactagctattgttacccagtggtgt
gagggctccagcttatatcaccatctccacatcatcgagaccaaattcgagatgatcaag
cttatagatattgcacggcagactgcgcagggcatggattacttacacgccaagtcaatc
atccacagagacctcaagagtaataatatttttcttcatgaagacctcacagtaaaaata
ggtgattttggtctagccacagtgaaatctcgatggagtgggtcccatcagtttgaacag
ttgtctggatccattttgtggatggcaccagaagtgatccgaatgcaagataaaaaccca
tatagctttcagtcagatgtctatgcatttgggattgttctatatgaattgatgaccgga
cagttaccttattcaaacatcaacaacagggaccagataatttttatggtgggacgagga
tatctttctccagatctcagtaaggtacggagtaactgtccaaaagccatgaagagattg
atggcagagtgcctcaaaaagaaaagagatgagaggccactctttccccaagaaaggtcc
agaagaaagtatagactctttaacagtggttacccctggaagattctcgcctctattgag
ctgctggcccgctcattgccaaaaattcaccgcagtgcatcagaaccctccttgaatcgg
gctggcttccaaacagaggattttagtctatatgcttgtgcttctccaaaaacacccatc
caggcagggggatatggagaatttgcagccttcaagtag

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