KEGG   Odobenus rosmarus divergens (Pacific walrus): 101385947
Entry
101385947         CDS       T05148                                 
Symbol
CACNA1S
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1S
  KO
K04857  voltage-dependent calcium channel L type alpha-1S
Organism
oro  Odobenus rosmarus divergens (Pacific walrus)
Pathway
oro04010  MAPK signaling pathway
oro04020  Calcium signaling pathway
oro04022  cGMP-PKG signaling pathway
oro04024  cAMP signaling pathway
oro04260  Cardiac muscle contraction
oro04261  Adrenergic signaling in cardiomyocytes
oro04270  Vascular smooth muscle contraction
oro04723  Retrograde endocannabinoid signaling
oro04725  Cholinergic synapse
oro04726  Serotonergic synapse
oro04727  GABAergic synapse
oro04911  Insulin secretion
oro04912  GnRH signaling pathway
oro04921  Oxytocin signaling pathway
oro04924  Renin secretion
oro04925  Aldosterone synthesis and secretion
oro04927  Cortisol synthesis and secretion
oro04929  GnRH secretion
oro04934  Cushing syndrome
oro04935  Growth hormone synthesis, secretion and action
oro05010  Alzheimer disease
oro05020  Prion disease
oro05022  Pathways of neurodegeneration - multiple diseases
oro05207  Chemical carcinogenesis - receptor activation
oro05410  Hypertrophic cardiomyopathy
oro05412  Arrhythmogenic right ventricular cardiomyopathy
oro05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:oro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101385947 (CACNA1S)
   04020 Calcium signaling pathway
    101385947 (CACNA1S)
   04024 cAMP signaling pathway
    101385947 (CACNA1S)
   04022 cGMP-PKG signaling pathway
    101385947 (CACNA1S)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    101385947 (CACNA1S)
   04929 GnRH secretion
    101385947 (CACNA1S)
   04912 GnRH signaling pathway
    101385947 (CACNA1S)
   04921 Oxytocin signaling pathway
    101385947 (CACNA1S)
   04935 Growth hormone synthesis, secretion and action
    101385947 (CACNA1S)
   04924 Renin secretion
    101385947 (CACNA1S)
   04925 Aldosterone synthesis and secretion
    101385947 (CACNA1S)
   04927 Cortisol synthesis and secretion
    101385947 (CACNA1S)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    101385947 (CACNA1S)
   04261 Adrenergic signaling in cardiomyocytes
    101385947 (CACNA1S)
   04270 Vascular smooth muscle contraction
    101385947 (CACNA1S)
  09156 Nervous system
   04727 GABAergic synapse
    101385947 (CACNA1S)
   04725 Cholinergic synapse
    101385947 (CACNA1S)
   04726 Serotonergic synapse
    101385947 (CACNA1S)
   04723 Retrograde endocannabinoid signaling
    101385947 (CACNA1S)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    101385947 (CACNA1S)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101385947 (CACNA1S)
   05020 Prion disease
    101385947 (CACNA1S)
   05022 Pathways of neurodegeneration - multiple diseases
    101385947 (CACNA1S)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    101385947 (CACNA1S)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    101385947 (CACNA1S)
   05414 Dilated cardiomyopathy
    101385947 (CACNA1S)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101385947 (CACNA1S)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:oro04040]
    101385947 (CACNA1S)
Ion channels [BR:oro04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   101385947 (CACNA1S)
SSDB
Motif
Pfam: Ion_trans Ca_chan_IQ GPHH PKD_channel CAC1F_C
Other DBs
NCBI-GeneID: 101385947
NCBI-ProteinID: XP_004392790
UniProt: A0A2U3VDR3
LinkDB
Position
Unknown
AA seq 1873 aa
MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLQNPLRKACINIVEWKPFETIILLT
IFANCVALAVYLPMPEDDNNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS
GWNVLDFIIVFLGVFTVILEQVNVIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP
SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFTGTDIVATVEDE
KPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW
VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLE
EDLRGYMSWITQGEVMDVEDLREGKLSLDEGGSDTESLYEIEGLNKIIQFVRHWRQWNRI
FRWKCHDVIKSKVFYWLVILVVALNTLSIASEHHTQPLWLTHLQDVANRVLLALFTIEML
MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMSPLGISVLRCIRLLRIFKITK
YWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFEDTEVRRSNFDNF
PQALISVFQVLTGEDWNSMMYNGIMAYGGPSYPGVLVCVYFIILFVCGNYILLNVFLAIA
VDNLAEAESLTSAQKAKAEERKRRKMSKGLPDKAEEEKSVMAKKLEQKPKGEGIPTTAKL
KIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSFF
IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFT
SVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSTISVVKILRVLR
VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDL
SKMTEKECRGYYYVYKHGDPTQMELRPRQWIHSDFHFDNVLSAMMSLFTVSTFEGWPQLL
YQAIDSYKEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE
LDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHY
NQSEEMNHISDILNVAFTIIFTLEMVLKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILS
EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF
IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVLLLFRCA
TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVI
MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP
HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR
TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTIQIQAGLR
TIEEEAAPEIRRTISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERNNSLPP
VMANQRPLQFAEIEMEELESPVFLEDFPQDPSTNPLAHANTNNANANIAYGNSNHSNRQV
FSSIHYEREFPGETETPAARGGAFGQPRRVLGPHSKSCVEQLKGQLTQREMPRSQAFPAP
CQRARAESPLPEEKRSPTPGSLPEEASHSRRTKESSPWCQTPATAQLIQEALVRGGLDTL
AADADFVLATGQALADACQMTPEEVEVAATELLKRQGSPEGPASALGCWSLRSSLGSLDL
HQGSQETLIPPRL
NT seq 5622 nt   +upstreamnt  +downstreamnt
atggagccgtcctcaccccaggatgagggcctgaggaagaaacagccgaagaagcccgtt
cctgagattctgccaaggccaccccgggccttgttctgcttgaccctccagaaccctctg
aggaaggcctgcatcaacatcgtggaatggaaacccttcgagacaatcatcttgctcacc
atctttgccaactgtgtggccctggctgtgtacctgcccatgccagaagatgacaacaac
actctgaaccttggcctggagaaactggagtatttcttcctcatcgtgttctcgattgaa
gccgccatgaagatcattgcctacggcttcctcttccaccaggatgcctacctgcgcagt
ggctggaatgtgctagacttcatcattgtcttcctgggggttttcaccgtgattctggaa
caggttaacgtcatccaaagcaacacagccccaatgagcagcaaaggggctggtctggac
gtcaaggccctgagagccttccgtgtgctcagacccctccggctggtgtccggggtcccg
agcctgcaggtggtcctcaactccatcttcaaggccatgctgcccctgttccacatcgcc
ctgctcgtcctctttatggtcatcatctatgccatcatcgggctggagctcttcaagggc
aagatgcacaagacctgctacttcactgggacagatatcgtggccacagtggaggacgag
aagccctcaccctgcgccaggacgggctcggggcgcccatgcaccatcaatggcagcgag
tgtcggggcggctggccggggcccaaccatggcatcacccacttcgacaatttcggcttc
tccatgctcaccgtgtaccagtgcatcaccatggagggctggactgacgtcctctactgg
gtcaatgatgccatcgggaacgagtggccctggatctattttgtcaccctcattctgctg
ggatccttcttcattctcaacctggtgctgggtgtcctgagcggggaattcactaaggag
cgggagaaggccaagtccagaggaacgttccaaaagctccgggagaagcagcagctggag
gaggacctgcggggctacatgagctggatcacgcagggcgaggtcatggacgttgaggac
ttgagagaagggaagctgtctttggatgaaggaggctccgacacagagagcctgtatgaa
atcgagggcttgaacaaaatcatccagttcgttcgccactggaggcagtggaaccgcatc
tttcgctggaagtgccatgatgtgatcaagtccaaggtcttctattggctggtgatcctg
gtcgttgccctcaacaccctgtcgatcgcctccgagcaccacacccagcctctgtggctg
acccacttgcaagacgtggccaaccgagtgctgctggccctcttcaccatcgagatgctg
atgaagatgtacgggctgggactgcgccagtacttcatgtccatcttcaaccgcttcgac
tgcttcgtggtgtgcagcggcatcctggagatcctgctcgtggaatcgggtgccatgagc
cccctgggcatctccgtgctgcgctgcatccgcctccttaggatcttcaagatcaccaag
tattggacgtctctgagcaacctggtggcgtccctgctcaactccatccgctccatcgcc
tccctgctgctgctgctcttcctcttcatcatcatcttcgccctgctgggcatgcagctc
ttcgggggcaggtatgacttcgaggacacggaggtgcggcgcagcaacttcgacaacttc
ccgcaggccctcatcagtgtcttccaggtcctgacaggtgaagactggaactccatgatg
tacaatgggatcatggcctacggcggaccgtcctatccgggggtgctcgtgtgtgtttat
ttcatcatccttttcgtctgtggcaattatatcctgctcaatgtcttcctggccattgct
gtggacaacctggctgaggccgagagcctgacttctgcccagaaggccaaggctgaggag
agaaagcgcaggaagatgtccaagggtctcccagacaaggcagaggaggagaaatcagtg
atggccaagaagctggaacagaaacccaagggtgagggcatccctaccacggccaagctg
aaaatcgatgaatttgaatctaatgtcaatgaagtgaaggatccctacccttcggctgac
ttcccaggcgatgatgaagaagatgagcctgagatccccgtgagcccccgaccacgcccc
ctggctgagctgcagctaaaagagaaggcagtacccattccagaagccagctccttcttc
atcttcagccccaccaacaagatccgtgtcttgtgtcatcgtattgtcaatgctacctgg
ttcaccaacttcatcctgctcttcatcctgctcagcagtgctgcactggccgctgaggac
cccatccgggccgagtctgtgaggaatcagatccttgggtattttgacatcgcgttcacc
tctgtcttcactgtggagattgtcctcaagatgacgacctacggcgccttcctgcacaag
ggctccttctgccgcaactacttcaacatcctggacctgctggtggtggccgtgtccctc
atctcaatgggacttgagtccagcaccatctccgtggtgaaaatcctgagggtgctgagg
gtgctcagacccctccgggccatcaacagagccaaagggctgaagcacgtggtgcagtgc
gtgtttgtggccatccgcaccatcgggaacatcgtcctggtcaccaccctcctgcagttc
atgttcgcctgcatcggcgtccagctcttcaaggggaagttcttcagctgcaatgactta
tccaagatgacggagaaggagtgcaggggctactactacgtgtacaagcatggggacccc
acgcagatggagctgcgtccgcgccagtggatacacagcgatttccactttgacaacgtg
ctttcggccatgatgtcactcttcacggtgtccacctttgagggatggcctcagctactt
taccaggccatagactcatacaaggaggacatgggtcccgtctacaataaccgggtggag
atggccatcttcttcatcatctacatcatcctcattgccttcttcatgatgaacatcttt
gtgggcttcgtcatcgtcaccttccaggagcagggggagactgagtacaagaactgtgag
ctggataagaaccagcgacagtgtgtgcagtatgccctgaaggcccgcccgctgaggtgc
tatatccccaaaaacccataccagtaccaggtgtggtatgtcgtcacctcctcctacttt
gaatacctgatgtttgccctcatcatgctcaacaccatctgcctgggcatgcagcactac
aaccagtcagaggagatgaaccacatctcggacatcctcaatgtggccttcaccatcatc
ttcaccctggagatggtcctcaagctcatggcgttcaaggccaggggctattttggagac
ccctggaatgtgtttgacttcttgattgtcatcggcagcatcatcgacgtcatcctcagt
gaaatcgacactttcctggcctccagcggaggactgtattgcctgggtggaggctgcggg
aacgttgacccagacgagagtgcccgcatctccagcgccttctttcgcctgttccgggtc
atgaggctgatcaagctgctgagccgggcagagggagtgcgcactctactgtggaccttc
atcaagtccttccaggccctgccctatgtggctctgctcatcgtcatgctcttcttcatc
tacgcagtcatcggcatgcagatgtttggtaagatcgccatggtggacgggacccaaata
aaccgcaacaacaacttccagacctttccacaagctgtgctgctgctcttcaggtgtgcg
acaggagaggcatggcaggagatcctgctggcctgcagctacggcaaattgtgtgaccct
gagtcagattacgccccgggtgaggagtacacgtgcggcaccaacttcgcctactactac
ttcatcagcttctacatgctctgtgctttcctgatcatcaacctctttgttgctgtcatc
atggacaactttgactacctcacgcgggactggtccatcctgggccctcatcacctggac
gagttcaaggccatttgggcagagtatgacccagaggcgaagggcagaatcaaacacttg
gatgtggtgactctgctgagacggatccagccccctctgggcttcgggaagttctgcccc
caccgggtggcatgtaagcggctggtgggtatgaacatgcccttgaacagcgatggcacg
gtcaccttcaatgccacactcttcgctctggtccgcacggcactcaagatcaagacggaa
ggtaactttgagcaggccaatgaggagctgagggccatcatcaagaagatctggaagaga
accagcatgaagctcctggaccaggtcattcctccaataggagatgatgaggtgactgta
gggaagttctacgccacatttctcatccaggagcacttccggaagttcatgaagcgccag
gaagagtattatgggtatcggcccaagaaggacaccatacagatccaggctggactgcgg
accattgaggaagaggcagctccagagatccgccgcaccatctcaggagacctgacagca
gaagaggagctggagagagccatggtggaggctgcgatggaggaagggatattccggagg
actggaggcctctttggccaggtggacaacttcctggaaaggaacaactccctgccccct
gtcatggccaaccagagacccctccagtttgctgagatagagatggaagagctggaatcg
cctgtcttcttggaggatttccctcaagatccaagcaccaaccctcttgctcatgccaat
accaacaatgccaacgccaacatcgcctatggcaacagcaaccatagcaacaggcaggtg
ttttccagcatccactacgaaagggagttccctggagagacagagacgcctgctgccaga
ggaggagcctttggccaaccccgaagggtcctgggaccccacagcaaatcctgtgtggaa
cagctaaaaggacagctgacccagagagaaatgcccagatcccaggcatttcctgccccc
tgccagcgtgccagggccgagtctcccctgcctgaggagaagaggagccccaccccgggg
tctctgcctgaggaagcatcccacagccgtaggaccaaggagagtagtccttggtgccaa
actccagcgacagcccagctgattcaagaggctctggttcgagggggcctggacaccttg
gcagctgatgctgactttgtcctggcgactggccaggccctggcagatgcctgccagatg
acaccagaggaagtggaggtggcagccacagagctactgaaaagacaagggtccccagag
ggtccggccagtgcccttggatgctggagcctcaggtcctcgctgggcagccttgacctg
catcagggctcccaggagaccctgatcccccccaggctgtga

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