KEGG   Odocoileus virginianus (white-tailed deer): 110126920
Entry
110126920         CDS       T10722                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
ovr  Odocoileus virginianus (white-tailed deer)
Pathway
ovr01521  EGFR tyrosine kinase inhibitor resistance
ovr01522  Endocrine resistance
ovr04010  MAPK signaling pathway
ovr04012  ErbB signaling pathway
ovr04014  Ras signaling pathway
ovr04015  Rap1 signaling pathway
ovr04022  cGMP-PKG signaling pathway
ovr04024  cAMP signaling pathway
ovr04062  Chemokine signaling pathway
ovr04066  HIF-1 signaling pathway
ovr04068  FoxO signaling pathway
ovr04071  Sphingolipid signaling pathway
ovr04072  Phospholipase D signaling pathway
ovr04114  Oocyte meiosis
ovr04140  Autophagy - animal
ovr04148  Efferocytosis
ovr04150  mTOR signaling pathway
ovr04151  PI3K-Akt signaling pathway
ovr04210  Apoptosis
ovr04218  Cellular senescence
ovr04270  Vascular smooth muscle contraction
ovr04370  VEGF signaling pathway
ovr04371  Apelin signaling pathway
ovr04380  Osteoclast differentiation
ovr04510  Focal adhesion
ovr04517  IgSF CAM signaling
ovr04540  Gap junction
ovr04550  Signaling pathways regulating pluripotency of stem cells
ovr04613  Neutrophil extracellular trap formation
ovr04620  Toll-like receptor signaling pathway
ovr04650  Natural killer cell mediated cytotoxicity
ovr04660  T cell receptor signaling pathway
ovr04662  B cell receptor signaling pathway
ovr04664  Fc epsilon RI signaling pathway
ovr04666  Fc gamma R-mediated phagocytosis
ovr04668  TNF signaling pathway
ovr04720  Long-term potentiation
ovr04722  Neurotrophin signaling pathway
ovr04725  Cholinergic synapse
ovr04726  Serotonergic synapse
ovr04730  Long-term depression
ovr04810  Regulation of actin cytoskeleton
ovr04910  Insulin signaling pathway
ovr04912  GnRH signaling pathway
ovr04914  Progesterone-mediated oocyte maturation
ovr04915  Estrogen signaling pathway
ovr04916  Melanogenesis
ovr04917  Prolactin signaling pathway
ovr04919  Thyroid hormone signaling pathway
ovr04921  Oxytocin signaling pathway
ovr04926  Relaxin signaling pathway
ovr04928  Parathyroid hormone synthesis, secretion and action
ovr04929  GnRH secretion
ovr04934  Cushing syndrome
ovr04935  Growth hormone synthesis, secretion and action
ovr05010  Alzheimer disease
ovr05022  Pathways of neurodegeneration - multiple diseases
ovr05034  Alcoholism
ovr05132  Salmonella infection
ovr05135  Yersinia infection
ovr05160  Hepatitis C
ovr05161  Hepatitis B
ovr05163  Human cytomegalovirus infection
ovr05164  Influenza A
ovr05165  Human papillomavirus infection
ovr05166  Human T-cell leukemia virus 1 infection
ovr05167  Kaposi sarcoma-associated herpesvirus infection
ovr05170  Human immunodeficiency virus 1 infection
ovr05200  Pathways in cancer
ovr05205  Proteoglycans in cancer
ovr05206  MicroRNAs in cancer
ovr05207  Chemical carcinogenesis - receptor activation
ovr05208  Chemical carcinogenesis - reactive oxygen species
ovr05210  Colorectal cancer
ovr05211  Renal cell carcinoma
ovr05212  Pancreatic cancer
ovr05213  Endometrial cancer
ovr05214  Glioma
ovr05215  Prostate cancer
ovr05216  Thyroid cancer
ovr05218  Melanoma
ovr05219  Bladder cancer
ovr05220  Chronic myeloid leukemia
ovr05221  Acute myeloid leukemia
ovr05223  Non-small cell lung cancer
ovr05224  Breast cancer
ovr05225  Hepatocellular carcinoma
ovr05226  Gastric cancer
ovr05230  Central carbon metabolism in cancer
ovr05231  Choline metabolism in cancer
ovr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ovr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110126920 (MAP2K1)
   04012 ErbB signaling pathway
    110126920 (MAP2K1)
   04014 Ras signaling pathway
    110126920 (MAP2K1)
   04015 Rap1 signaling pathway
    110126920 (MAP2K1)
   04370 VEGF signaling pathway
    110126920 (MAP2K1)
   04371 Apelin signaling pathway
    110126920 (MAP2K1)
   04668 TNF signaling pathway
    110126920 (MAP2K1)
   04066 HIF-1 signaling pathway
    110126920 (MAP2K1)
   04068 FoxO signaling pathway
    110126920 (MAP2K1)
   04072 Phospholipase D signaling pathway
    110126920 (MAP2K1)
   04071 Sphingolipid signaling pathway
    110126920 (MAP2K1)
   04024 cAMP signaling pathway
    110126920 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    110126920 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    110126920 (MAP2K1)
   04150 mTOR signaling pathway
    110126920 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    110126920 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110126920 (MAP2K1)
   04148 Efferocytosis
    110126920 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    110126920 (MAP2K1)
   04210 Apoptosis
    110126920 (MAP2K1)
   04218 Cellular senescence
    110126920 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110126920 (MAP2K1)
   04540 Gap junction
    110126920 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    110126920 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110126920 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    110126920 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    110126920 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    110126920 (MAP2K1)
   04660 T cell receptor signaling pathway
    110126920 (MAP2K1)
   04662 B cell receptor signaling pathway
    110126920 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    110126920 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    110126920 (MAP2K1)
   04062 Chemokine signaling pathway
    110126920 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110126920 (MAP2K1)
   04929 GnRH secretion
    110126920 (MAP2K1)
   04912 GnRH signaling pathway
    110126920 (MAP2K1)
   04915 Estrogen signaling pathway
    110126920 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    110126920 (MAP2K1)
   04917 Prolactin signaling pathway
    110126920 (MAP2K1)
   04921 Oxytocin signaling pathway
    110126920 (MAP2K1)
   04926 Relaxin signaling pathway
    110126920 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    110126920 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    110126920 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    110126920 (MAP2K1)
   04916 Melanogenesis
    110126920 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    110126920 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    110126920 (MAP2K1)
   04726 Serotonergic synapse
    110126920 (MAP2K1)
   04720 Long-term potentiation
    110126920 (MAP2K1)
   04730 Long-term depression
    110126920 (MAP2K1)
   04722 Neurotrophin signaling pathway
    110126920 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    110126920 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110126920 (MAP2K1)
   05206 MicroRNAs in cancer
    110126920 (MAP2K1)
   05205 Proteoglycans in cancer
    110126920 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    110126920 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    110126920 (MAP2K1)
   05230 Central carbon metabolism in cancer
    110126920 (MAP2K1)
   05231 Choline metabolism in cancer
    110126920 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110126920 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110126920 (MAP2K1)
   05212 Pancreatic cancer
    110126920 (MAP2K1)
   05225 Hepatocellular carcinoma
    110126920 (MAP2K1)
   05226 Gastric cancer
    110126920 (MAP2K1)
   05214 Glioma
    110126920 (MAP2K1)
   05216 Thyroid cancer
    110126920 (MAP2K1)
   05221 Acute myeloid leukemia
    110126920 (MAP2K1)
   05220 Chronic myeloid leukemia
    110126920 (MAP2K1)
   05218 Melanoma
    110126920 (MAP2K1)
   05211 Renal cell carcinoma
    110126920 (MAP2K1)
   05219 Bladder cancer
    110126920 (MAP2K1)
   05215 Prostate cancer
    110126920 (MAP2K1)
   05213 Endometrial cancer
    110126920 (MAP2K1)
   05224 Breast cancer
    110126920 (MAP2K1)
   05223 Non-small cell lung cancer
    110126920 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110126920 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    110126920 (MAP2K1)
   05161 Hepatitis B
    110126920 (MAP2K1)
   05160 Hepatitis C
    110126920 (MAP2K1)
   05164 Influenza A
    110126920 (MAP2K1)
   05163 Human cytomegalovirus infection
    110126920 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110126920 (MAP2K1)
   05165 Human papillomavirus infection
    110126920 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110126920 (MAP2K1)
   05135 Yersinia infection
    110126920 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110126920 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    110126920 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    110126920 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110126920 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110126920 (MAP2K1)
   01522 Endocrine resistance
    110126920 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ovr01001]
    110126920 (MAP2K1)
Enzymes [BR:ovr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     110126920 (MAP2K1)
Protein kinases [BR:ovr01001]
 Serine/threonine kinases: STE group
  STE7 family
   110126920 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 110126920
NCBI-ProteinID: XP_020732513
UniProt: A0A6J0W498
LinkDB
Position
6:6725462..6802220
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgacttcgagaagatcagtgagctgggtgccggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggactcgttatggccagaaagctgattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgag
tgcaactccccttacatcgtgggcttctacggggcgttctacagcgacggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagattatgcacagagacgtcaagccgtccaacatcctagtgaacagc
cgtggggagatcaagctctgtgacttcggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggcagtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagacttgaagcaactcatggttcacgctttc
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccatgcggctggcgtctaa

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