Pteropus alecto (black flying fox): 102879945
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Entry
102879945 CDS
T02993
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X1
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
pale
Pteropus alecto (black flying fox)
Pathway
pale00220
Arginine biosynthesis
pale00330
Arginine and proline metabolism
pale01100
Metabolic pathways
pale04020
Calcium signaling pathway
pale04022
cGMP-PKG signaling pathway
pale04066
HIF-1 signaling pathway
pale04071
Sphingolipid signaling pathway
pale04151
PI3K-Akt signaling pathway
pale04370
VEGF signaling pathway
pale04371
Apelin signaling pathway
pale04611
Platelet activation
pale04915
Estrogen signaling pathway
pale04921
Oxytocin signaling pathway
pale04926
Relaxin signaling pathway
pale04931
Insulin resistance
pale04933
AGE-RAGE signaling pathway in diabetic complications
pale05415
Diabetic cardiomyopathy
pale05417
Lipid and atherosclerosis
pale05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
pale00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
102879945 (NOS3)
00330 Arginine and proline metabolism
102879945 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
102879945 (NOS3)
04371 Apelin signaling pathway
102879945 (NOS3)
04066 HIF-1 signaling pathway
102879945 (NOS3)
04020 Calcium signaling pathway
102879945 (NOS3)
04071 Sphingolipid signaling pathway
102879945 (NOS3)
04022 cGMP-PKG signaling pathway
102879945 (NOS3)
04151 PI3K-Akt signaling pathway
102879945 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
102879945 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
102879945 (NOS3)
04921 Oxytocin signaling pathway
102879945 (NOS3)
04926 Relaxin signaling pathway
102879945 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
102879945 (NOS3)
05418 Fluid shear stress and atherosclerosis
102879945 (NOS3)
05415 Diabetic cardiomyopathy
102879945 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
102879945 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
102879945 (NOS3)
Enzymes [BR:
pale01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
102879945 (NOS3)
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GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
102879945
NCBI-ProteinID:
XP_006920687
LinkDB
All DBs
Position
Unknown
AA seq
1207 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPVSEPNWTPAPAPLPEPDHSPTLALNS
PPPTRSPEGPKFPRVKNWEVGSITYDTLSARAQQDGPCTPRRCLGSLVFPRKLQGRPSQG
PPPPEQLLSQARDFIDQYYSAIKRSGSQAHEQRLEEVEAEVAATGTYQLRESELVFGAKQ
AWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICSHIKYATNKGNLRSAITVFPQRTP
GRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAP
DESPELFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGW
YMSTEIGSRNLCDPHRYNILEDVAVCMDLDTRTSSSLWKDKAAVEINLAVLHSYQLAKVT
IVDHHAATSSFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQ
PDPWKGSTAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQ
QLGRLFRKAFDPRVLCMDEYDVVFLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGP
YNSSPRPEQHRSYKIRFNSVSCSDPLVSSWRRKRKASSNTDSAGALGTLRFCVFGLGSRA
YPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDA
KAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLTYVHRRKMFQATVLSVENLQSSKSTR
ATILVRLDTGGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPGEAMAVEQLEKGS
PGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPRLLQLLSTLAEEPGEQQELETLSQD
PRRYEEWKWFRCPTLLEVLEQFPSVALPAALLLTQLPLLQPRYYSVSSAPSAHPGEIHLT
VAVLAYRTQDGLGPLHYGVCSTWLSQLKAGAPVPCFIRGAPSFRLPPDPSLPCILVGPGT
GIAPFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTA
FSREPASPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGD
MELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWSFDPP
GPDTPGP
NT seq
3624 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagcgtgggccaggagcctgggccaccctgcggcctggggctggga
ctgggcctcgggctgtgcggcaagcagggcccagcctccccggtgtctgagcccaactgg
acgccagcacctgcacccctgcctgagccagaccacagccccaccctggctctcaacagc
cccccgcccacccggtccccggaggggcccaagttccctcgcgtgaagaactgggaagtg
gggagcatcacctacgacaccctgagtgcccgggcacagcaggacggaccctgcacccca
agacgctgcctgggctccctggtatttccacggaaactgcagggacggccatcccagggc
cccccaccccccgagcagctgctgagccaggccagggacttcatcgaccagtactacagc
gccatcaagcggagcggctcccaggcccacgagcagcggcttgaggaggtggaagccgag
gtggcagccacaggcacctaccagcttcgggaaagcgagctagtgttcggggccaagcag
gcctggcgcaacgctccccgctgcgtgggccggatccagtgggggaagctgcaggtgttt
gacgcccgtgattgcagctctgctcaggagatgttcacctacatctgtagccacatcaag
tatgccaccaacaagggcaacctccgctccgcaatcacagtgttcccccaacgcaccccg
ggccgcggggacttccgcatctggaacagccagctggtgcgctacgcgggctaccggcag
caggacggctcggtgcgcggggacccagccaacgtggaaatcaccgagctctgcatccag
cacggctggaccccgggaaacggccgcttcgacgtgctgcccctgctgctccaggcccca
gacgagtccccagaactcttcactctaccccccgagctagtcctcgaggtgcccctggag
caccccacgctggagtggttcgcggccctggggctgcgctggtacgccctcccggccgtg
tccaacatgctgctggagatcgggggcctggagttcccagcggcgcccttcagcggctgg
tacatgagcacggagatcggctcgcggaacctgtgtgacccgcaccgctacaacatcctg
gaggatgtggccgtctgcatggacctggacacccggacgtcctcgtccctgtggaaagac
aaggcggccgtggaaatcaacttggcggtgctgcacagttaccagctggccaaagtgacc
attgtggaccaccatgccgccacctcctccttcatgaagcacctggagaacgagcagaag
gcgagggggggctgccctgccgattgggcctggatcgtgccccccatctcgggcagcctc
acccctgtgttccatcaggagatggtcaactatttcctgtcccctgccttccgctaccag
ccggatccgtggaaggggagcacagccaagggtgccggcatcaccaggaaaaagaccttt
aaggaagtggccaatgctgtgaagatctctgcctcactcatgggcaccgtgatggccaag
cgtgtgaaggccacaatcctgtatggctctgagaccggccgggcccagagctatgcacag
cagctggggaggctcttccggaaggctttcgacccccgggtcctgtgcatggatgagtat
gacgtggtgttcctcgagcacgagacgctggtgttggtggtgaccagcacatttgggaat
ggggatcccccagaaaatggagagagtttcgcggcggccctgatggagatgtccggcccc
tacaacagctcccctcggcccgagcagcacaggagttacaaaatccgcttcaacagcgtc
tcttgctcagaccccctcgtgtcctcctggcggcggaagagaaaggcgtccagtaacacg
gacagcgccggggccctggggaccctcaggttctgtgtgttcgggctgggctcccgggcg
tacccccacttctgtgcctttgctcgtgcggtggacacacggctggaagagctgggcggg
gagcggctcctgcagctgggccagggcgacgagctgtgcggccaggaggaggccttccgc
ggctgggcccaggctgccttccaggcctcctgtgagaccttctgcgtgggagaggatgcc
aaggccgccgcccgggacatattcagccccaaacggagctggaagcgccagaggtaccgg
ctgagtgcccaggctgagggcctccagctgctgccaggcctgacctacgtgcacagacga
aagatgttccaggccacagtcctctcagtggaaaacctgcagagcagcaagtccactcgg
gccacgatcctcgtgcgcctggacaccggaggccaggaggggctccagtaccagccaggg
gaccacataggcatctgcccgcccaaccggcccggcctcgtggaggcgctgctgagccgt
gtggaggacccgccgccgccgggcgaggccatggccgtggagcagctggagaagggcagc
cccggtggccctcccccgggctgggtgcgggacccccggctgcccccgtgcaccctgcgc
caggctctcaccttcttcctggacatcacttccccgcccagcccccgactccttcaactg
ctcagcaccctggctgaagagcccggcgaacagcaggagctagagaccctcagccaggac
ccccggcgctacgaggagtggaagtggttccgctgccccacgctgctggaggtgctggag
cagtttccgtccgtggctctgcccgccgcgctgctcctcacccagctgcccctgctccag
ccccggtactactccgtcagctcggcgcccagcgcccaccccggagagatccacctcacg
gtggccgtgctggcatacaggacccaggatgggctgggccccctgcactacggcgtctgc
tccacgtggctgagccagctcaaggccggagcccctgtcccctgcttcatcaggggggct
ccctccttccggctgccaccggaccccagcttgccctgcatcctggtgggcccaggcact
ggcatcgcccccttccggggcttctggcaggagcggctacatgacattgagagcaaaggg
ctgcagcccgcccctatgaccttggtgttcggctgccgatgctcccagctcgaccacctc
taccgcgacgaggtgcaggatgcccagcagcgcggagtgttcggccgtgtcctcactgcc
ttctcccgggaacccgccagccctaagacctacgtacaggacatcctgcggacagagctg
gctgctgaggtgcaccgcgtgctgtgcctcgaacgaggccacatgtttgtctgcggcgat
gtcaccatggcaaccagcgtcctgcagacagtgcagcgcatactggcgacagagggcgac
atggagctggatgaggccggagacgtcatcggcgtgctgcgggatcagcaacgctatcac
gaggacattttcgggcttacgctacgcacccaggaggtgacaagccgcattcgcacccag
agcttttccttgcaggagcggcatctgcgcggcgcagtgccctggtcgttcgacccgccc
ggcccagacacgcccggcccctga
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