Pteropus alecto (black flying fox): 102887448 Help Entry 102887448         CDS       T02993                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism pale  Pteropus alecto (black flying fox) Pathway pale04020   Calcium signaling pathway pale04371   Apelin signaling pathway pale04713   Circadian entrainment pale04921   Oxytocin signaling pathway pale04970   Salivary secretion pale05010   Alzheimer disease pale05012   Parkinson disease pale05020   Prion disease pale05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pale00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102887448 (RYR3)    04020 Calcium signaling pathway     102887448 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     102887448 (RYR3)   09154 Digestive system    04970 Salivary secretion     102887448 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     102887448 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102887448 (RYR3)    05012 Parkinson disease     102887448 (RYR3)    05020 Prion disease     102887448 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     102887448 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pale04040]     102887448 (RYR3) Ion channels [BR:pale04040]  Voltage-gated cation channels   Ryanodine receptor    102887448 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  102887448 NCBI-ProteinID:  XP_015451341 LinkDB All DBs Position Unknown AA seq 4874 aa AA seqDB search MDLWRKDFSVRRSKTPEVCLLKEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSE AKYVPPDLCVCNFVLEQSLSVRALQEMLANTGENGSEGAAQGGGHRTLLYGHAILLRHSF SRMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSSERYLHLSISNATIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLT ILSTDQNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYL ALTEDQGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFV QHVASGLWVTYKAQDAKTPRLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTT ALFSQFISGNSRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNL FKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNC AQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIRSIISLLDKHGRNH KVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINNVTSIRPNILLGVAEGSA QYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFD GLHLWSGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLF FPVVSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDTEGIR DLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIR DDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLSK NYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKR NPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFR VERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVALGADDQAFVFEGSRGQRWHQGS GYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGL SQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIE VVRIDGTMDSPPCLKVTHKTFGTQNSNASMIYCRLSMPVECHSSFSHSPCLDSEAFQKRK QMQEILSQTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCMVTVTLGDER GRVHESVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLLDLAMGMLSFSANGRELGTCY QVEPNTKVFPAVFLQPTSTSLFQFELGKLKTAMPLSAAIFKSEEKNPVPQCPPRLDVQTI QPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLM QFHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHL ANAKERKLMMKNEYIIPINSTTRKIRLYPDEFKRHGLPGVGLRTCLKPGFRFSTPCVVMT SEEHQKQSPEIPLEILKTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVM GVFDDDDVRQILLLIDPSVFGEHSGETEEGAEKEEVTQVEEKAVEAGEKASKEAPVKGLL QTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMS AALTARKTKEFRSPPQEQINMLLNFQLGENCPCPDEIREELYDFHEDLLTHCGVPLEGEE EEEEDSSWTGKLRAFLYKIRGPPKPEKEQPKEEEERCPTTLKELISQTMIRWAQEDQIQD AELVRMMFTLLRRQYDSVGELLRALRKTYSISQASVSDTIGLLAALGQIRCLLSVRMGKE EELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCR FLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLE EPDLEKVVTYLAGCGLQSCAMLLARGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENAS VVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGCKREVSTEDNEDE EIVHMGNAIMSFYSALIDLLGRCAPEMHLIRTGKGEAIRIRSILRSLVPTEDLVGIISIP LKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQAFLLHLLEVGFLPDLRAS ASLDTVSLSTTEAVLALNRYVCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGR SLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWK YYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPD YLDTRISATLEKQISVDTDGNFDPKPINTMNFPVPEKLEYIVTKYAEHSHDKWACDKSQN GWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGDALA QQRENEKLRNVSQASQGNSYSPAPLDLSNVVLSKELQGMVEVVAENYHNIWAKKKKLELE SKGGGSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRF AYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRL YFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTL DTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVA LLPILTSIFEHVAQHQFGADLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLA SLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEIND LAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNI LKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQL KADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNSRSNWLKSPDADSDQLFRMVA EVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRR GDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHLRNNLHL QEKSDDPAVKWQLNLYKDVLKSEEPSNPERTVERVQRISAAVFHLEQVEQPLRSKKAVWH KLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYFFEEKLVQDLAKSP KVEEEEEEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEE EEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAIL NGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTL IVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLR LQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRL WDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMV DTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGILSKKEFQKAMEGQKQYTQ SEIEFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLD PAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEG GEQEKMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYTSEIEGEEEDKKSF ESASAFAMACASVKRNVANFLKRATLKNLRKQYRKVKKMTVKELVRVFFSFFWMMFVGLF QLFFTILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAVEAERAEVT EPGITTELVHFIKGEKGNADIMSDLFGFHSKKEGGIKHGPEVGLGDLSEIIGKDEPPTLE STVRKKRKAQAAEMKAADESEGKVEPEKADMEDGEKEDTAREGEQAKALWAEVTKKKKRR RGQKVEKPEALMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEE PLEEEAEDIANLWHSFNDEEEEEAMVFFVLQESTGYMAPTLRALAVIHTVISLVCVVGYY CLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKR KVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVV FTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL LAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIED PAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGI GNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP AGDCFRKQYEDQLG NT seq 14625 nt NT seq  +upstreamnt  +downstreamnt atggatctttggcgcaaagatttcagtgtcaggcgctccaagactccagaggtctgtcta ttgaaggaagatgaagtggttctccagtgcatcgcgaacattcacaaggagcaaaggaag ttctgcctagcagccgagggacttgggaatcgcctgtgcttcttggaacccacttcagaa gccaagtatgttcctccagatctctgcgtctgcaattttgtgctggaacagtccctctct gtcagagccctacaggaaatgctcgccaacacaggtgaaaatggcagcgaaggggcagca caagggggtggccacaggaccctgctgtatggccacgcgattctcctgcggcactctttc agcagaatgtatctaacatgtttgactacatcgagatcccagacagataaacttgccttt gatgtaggtctacgggaacatgccacaggggaagcctgttggtggaccatacatcctgct tccaaacagaggtccgagggagaaaaagttcgaattggagatgacctcatccttgtcagc gtgtcttctgaaagataccttcatctctccatatcaaacgctaccatacaagtggatgcc tcttttatgcaaacactctggaatgtacatcctacatgctcaggaagtagcatcgaagaa ggatacctacttggtgggcatgtggtacgtcttttccatggtcatgatgagtgtctgacg atactatctacagaccagaatgattcccagcacaggaggatattctatgaagcgggagga gctgggacacgagccagatctctctggagagtggaaccccttcggataagctggagtggc agtaacatcagatggggccaggctttccgactgcggcacctcaccacaggccactacctg gccctgacagaggaccaaggccttatactgcaagaccggggaaagtcagacaccaagtcc acagccttctctttcagggcatcaaaggaaatcaaggagaaattggattccagtcacaag cgagatatagaaggcatgggagttccagaaataaagtatggagattctgtctgctttgtc cagcatgtagccagtggtctgtgggtgacctacaaagcacaggatgccaagacaccccgc cttggacctctgaaaagaaaggtcatactccatcaggaaggccacatggatgatgggtta acactgcagagatgccagcatgaggagtcccaggctgctcggatcatccggaacacaaca gccttattcagccagtttataagtgggaacagtcgcacagctgcccccatcaccctgcca atagaagaagtcctgcagactttacaggacttgatcgcctacttccagcccccagaggag gagatgcagcatgaagacaagcagaacaagctccgctcgctcaaaaacagacagaatctt ttcaaggaagaaggaatgttggccctcgtgttaaattgcatcgatcgcttaaatatctac aatagtgtagcacactttgctggaattgcaagggaagagagtggcatggcctggaaagaa attctgaaccttctatacaaattgttggccgccctcattcgtggaaacagaaacaattgt gctcaattctccaataaccttgattggctaatcagcaaattggacagactggaatcttcc tcaggtatcttggaagttttgcactgcatcctgattgaaagcccagaagccttaaatctg atagcagagggccacatcaggtccatcatctccctgttggataagcatggacggaatcac aaggttctggatgtgctgtgctccctctgtctctgcaatggggttgcagtgagagccaac caaaatctgatctgtgacaacttgcttcccaggagaaacctgctcctgcagacacggctg attaacaatgtgacaagtattcgaccaaatatcttgctgggggtcgctgagggctcagcc cagtacaagaagtggtacttcgagctcattatcgaccaagtggaccccttcctaacagca gagcccacacacttgcgggtgggctgggcctcttcctcaggctatgctccgtaccccgga ggcggagaaggatggggaggcaacggcgttggcgatgacctgtactcctatggctttgat ggacttcacctttggtcaggccgcattcccagagccgtggcctccatcaaccagcacctc ctgaaatcagatgacgtggtgagctgttgcctggacctcggagtgcccagcatctctttc cgcatcaatgggcagcctgtgcaggggatgtttgagaatttcaacacagatgggctcttc ttccctgtggtgagcttttcagcaggtgtcaaagtacgtttcctgatgggtggacgtcat ggagaatttaagtttctgcctccttctggctatgccccttgctatgaagccttacttccc aaagaaaagatgagattggagcctgtcaaagaatataaacgtgatactgaaggcattaga gacctactgggtaccacccagtttctctcccaagcctctttcatcccatgccccatagac accagtcaggttgttttgccacctcacctagagaagattcgagacagactggctgaaaac atccacgagctctggggaatgaacaaaatagagcttggctggacttttggcaagatacgg gatgacaataaaagacaacacccctgccttgtggagttttcaaagctacctgaaactgag aagaattataacctacagatgtcaaccgaaaccttaaaaaccctcctggccttggggtgc cacattgctcacgttaatccagctgctgaagaggatctcaagaaggtcaaactgtccaaa aactacatgatgtccaatggctataagccagcccctttggatttgtctgatgtgaagctg ttacctcctcaggaaattttagtggataagcttgcagaaaatgcacataatgtttgggca aaggacagaataaaacaaggatggacctatggcattcaacaggatttgaagaacaaaaga aatccccgtctggtgccatatgcgttactggatgagcgtaccaagaagtcaaacagggac agccttcgtgaagctgttcggacgtttgttggttacggctataacatcgagccatcagac caagaactagctgacccagctgtggagaaagtcagcattgacaagattcgattcttccgg gtagagcgatcctatgcagtgagatctggaaagtggtatttcgagtttgaggtggtgact ggaggagacatgcgtgtcggctgggccaggccaggctgtcggcctgatgttgcactggga gccgatgaccaagcctttgtgttcgaaggcagccggggccagcgctggcatcaagggagt gggtattttggccgtacctggcagccaggagatgtggttggatgtatgattaacctggat gatgcttcaatgatcttcacactgaatggggagctgctgatcaccaacaaaggctctgaa cttgcctttgctgattacgagatcgagaatggctttgtgcccatctgctctctgggactg tctcagatcggccgcatgaatctcgggatggatgccagtaccttcaagttttataccatg tgcggcctccaagagggctttgagccttttgctgtcaacatgaaccgagatgttgcaatg tggttcagcaagcgcctcccaacgtttgtcaatgtgccaaaggatcatccacatatagag gtcgtgaggatcgatggcaccatggacagccctccatgcctcaaagtgacccacaagacg tttggcacacagaatagcaatgccagcatgatctactgccgcctgagcatgcccgtcgag tgccactcctccttcagtcacagcccctgtctggacagtgaagctttccagaaaaggaaa cagatgcaagaaatactctctcaaacaaccacacaatgctactacgcaatccgcatcttt gctggacaggacccctcctgtgtctgggtcggatgggtgactcccgactatcacttatac agtgaaaagtttgacctgaataaaaactgtatggtgactgttactctgggggatgaaaga ggccgggtccatgaaagtgtaaagcgcagcaactgctacatggtctggggtggggacatt gtggccacttcccaacgatcgagtcgcagcaacgtggacctggagatcggctgcctcttg gatctggcaatgggcatgttgtccttctcagccaatgggagagaactcggcacctgctac caggtggaacccaataccaaagtatttccagcagtcttcctgcagcctacaagcacttct ttgtttcagtttgaacttgggaagctgaagactgcaatgcccctgtcggcggccatattt aagagtgaagaaaagaacccagtcccacagtgtccacctcgcctagacgtccaaaccatc cagcctgtgctctggagccgcatgcccagcagtttcctgaaggtggagacggagcgggtg agcgagcgccatggctgggtggtgcagtgcctggagcccctgcagatgatggcgctccac atccccgaggagaacaggtgtgtggatatcctggagctctgcgagcaggaggacctgatg cagttccactatcacacgctaagactctacagtgccgtgtgtgccctgggaaacagccga gtagcctatgccctgtgcagccacgtggacctctcccagctcttctacgccattgataac aagtacctccccggcctccttcggtctggtttctatgacctgctcatcagcatccatttg gccaatgctaaggagagaaagctgatgatgaagaatgagtacatcatccccattaacagc accactaggaaaatccgcctgtacccagacgagttcaagaggcatgggctgcctggggtg ggcctgagaacgtgcctcaagccaggattcagattctccaccccttgcgttgtcatgacc agtgaggagcatcagaagcagagccccgagattcccttggagattctcaagacgaaggca ttgagcatgctaacagaggccgtgcaatgcagtggggctcacatccgggaccctgttggg gggtctgtggagttccaatttgtgcctgtgctgaaactcattggaacgctgctggtcatg ggagtgtttgatgatgatgacgttcggcagatcctcctcctgatcgatccctctgtgttt ggggagcacagtggagagacagaagagggagcagaaaaggaagaagtgactcaggtagag gagaaggcagtggaggctggggaaaaggccagcaaggaggctccagtcaaaggcttgtta cagacccgattaccagagtccgtcaagctgcagatgtgtgagctcctcagctatctctgt gactgtgagctgcagcaccgagtggaggccatcgtggcctttggcgacatttatgtctcc aagctccaggcaaatcagaagttccgctacaatgagctcatgcaggccctgaacatgtct gcggccctgaccgcccggaagaccaaggagttccgctcacccccacaggagcagattaac atgcttcttaactttcaactgggagagaactgcccctgcccagacgagatccgggaggag ctgtatgacttccacgaggaccttctcactcactgcggagttcccctggagggggaggaa gaagaggaagaagacagctcctggactggaaaactccgtgccttcttatacaaaatcaga ggccctcccaagccagagaaagagcagccgaaagaggaggaagagagatgccctaccacg ctgaaggagctcatctcccagacgatgattcgctgggcccaagaggaccagatccaggac gcagagttggtccggatgatgttcacgctcctccggaggcagtacgacagcgtcggggag ctgctgcgggcgctgcgcaagacctacagcatcagccaggcctctgtgagcgacactatc ggcctgctggctgccctcggccagattcgctgcctcctcagtgtcaggatgggcaaggaa gaggagctgcttatgatcaatgggctgggagacataatgaacaacaaggtgttctaccag caccccaacctcatgcgagtcctcggcatgcacgagacagtgatggaggtgatggtgaac gtgttgggtgcggagaaatcccagattgcttttccaaagatggttgctagctgttgccgc ttcctttgctatttctgtcgaattagccggcaaaatcagaaggccatgtttgagcatcta agttacctgctggagaacagcagtgttggtctagcctccccgtcgatgaggggttccact ccactggatgtggcagcttcctctgtgatggacaacaacgagttagcgctgggcttagag gaaccagacctcgagaaggtggtgacctacttggcaggctgtggtctccagagctgcgcc atgcttctggccagagggtaccctgatgtcggctggaaccccatcgaaggggagcgctac ctgtccttcctgaggtttgctgtcttcgtgaacagtgaaagtgtggaagaaaatgctagt gtcgtggtcaagctgctcatcagacgccctgagtgcttcggcccagcgctgcggggtgaa ggaggaaacggtctgttggcagccatgcaaggcgccatcaagatctctgagaacccagcc ctggacctcccctctcagggatgcaagagagaagtcagcacagaggacaatgaagatgaa gagatcgtgcacatgggcaatgcaattatgtcattttattcagctcttatagatcttctg ggccgctgtgctcctgaaatgcaccttatccggacaggaaaaggggaagccatcaggatc aggtcaattctacgctcccttgtccccacagaggacttggttggaatcatcagcatcccc ttgaaactgccctccctgaacaaagatgggtcggtgagtgagccagatatggcggccaac ttctgccctgaccacaaggcaccgatggtgctgttcttggaccgcgtttatggcattaag gatcaagcttttctgctccacttgctggaggttggatttttgccggacttaagagcctct gcctctctagatacagtctcgctgagcaccacagaggccgtgctggcgctaaataggtat gtgtgttccgccgtgctcccgctcctcacgagatgcgcccctctctttgctggaacagaa cactacacctctttgatcgattctacactgcagacaatatacaggctttccaagggacgt tccctcaccaaagctcagagggacaccatagaagaatgtttgcttgccatctgcaatcac ttgaggccttccatgttacagcagctcctgcgacgtcttgtttttgatgtgccccaactc aacgaatactgcaaaatgcctcttaagcttctgacaaatcactatgaacagtgctggaag tattactgtctgccttcaggatgggggagctatggtctcgctgtggaagaagaactacac ctgacagaaaagctcttctgggggatttttgactccctctctcataagaagtatgaccca gaccttttccgaatggccctgccttgtctcagtgctatagctggggccttgccaccagat tatttagataccagaatctcggccacactggagaagcagatctcagtggatacagatggc aactttgaccccaaacctatcaacaccatgaatttccccgtgcctgaaaaattggaatac atcgtcaccaagtatgctgagcattcacatgataaatgggcctgcgacaagagtcagaat ggatggaaatatggaatttccctggacgaaaacgtgaagacccatccattgatcagacct tttaagacattaacagagaaggagaaagaaatttatcgctggccggccagagagtccctg aaaaccatgctggctgtgggttggactgtggagaggaccaaagagggagacgccctagct caacagcgggaaaatgagaagcttcgaaacgtgtcccaagccagccagggcaacagctac agccctgctcccctggacctgtccaacgtggtgctctccaaagagctccagggaatggtg gaggtggtggctgagaactatcacaacatctgggccaagaagaagaagctggagctagag agcaaaggtggtggcagtcaccctctcttggtaccatatgacaccttgactgccaaggaa aagtttaaggaccgagagaaggcacaggacctgtttaaattcctccaagtgaatggcatt gtggtttctagaggtatgaaggatatggagctggatgcctcctccatggagaagaggttt gcctataaatttttgaagaagatcctgaaatatgttgattccgctcaagagtttattgcc catttggaagccattgtcagcagtgggaaaactgaaaagtctccccatgaccaggagatc aaattctttgccaaagttctcctcccgctggtggaccagtacttcaccaatcaccgcctc tatttcctgtcatcccctctgaagccgctgagcagcagcgggtacgcctcccataaggag aaagaaatggtggccagcctgttctgcaaacttgctgctcttgttcgacacaggatttcc ctctttgggagtgactctactacaatggtgagctgtcttcacatcttagctcagacactt gacacaaggactgtcatgaagtcaggctccgagctggtgaaagccggcttacgagccttc ttcgaaaatgctgcagaagacttagagaagacttcggaaaacttgaagcttgggaagttt acccattccagaacacagattaaaggtgtttctcagaacatcaactacaccacggtggcg ctgctccccatcctgacgtccatctttgagcatgttgctcaacatcagtttggggcggat ttactcttgggtgatgtgcagatttcatgctaccacatcctgtgcagcctctactccctt gggacgggaaagaacatctatgttgaaagacaacgtcctgcccttggagaatgtctggct tcactggcagctgccatccccgtggcattcctcgagcccactcttaaccgctacaatcca ctctcagtcttcaacaccaagacccccagagagagatctattctggggatgccagacaca gtagaagagatgtgtcctgacatcccccagctagaaggcctgatgaaggaaatcaacgac ctggctgagtcaggggcccggtataccgagatgccccacgtcatcgaggtgatcttgcct atgctctgcaactacctgtcctactggtgggagcgagggcctgagcacctgccccccagc acagggccctggtgcaccaaggtcacctctgaacacctcagcgtcatcctgggcaacatt ctgaaaatcatcaacaacaacctgggcatcgacgaggcctcctggatgaagcgcattgca gtgtatgctcagccaatcatcagcaaagccaggcctgacctgctgagaagccacttcatc ccaactctggagaagctaaagaaaaaggccgtcaagactgtgcaggaagaggagcagctg aaagccgacagcaaaggggacactcaggaggcagagctcctcatcctggacgagttcgca gtcctctgcagagacctctacgccttctaccccatgctgatccgctacgtggacaacagc agatctaactggctcaaaagccctgatgctgattctgaccagctcttccgtatggtggca gaagtcttcatcctgtggtgtaaatctcacaacttcaagagggaagagcaaaatttcgtg attcagaatgaaattaataatttggcatttttaactggagacagcaaaagcaagatgtca aaagccatgcaagtaaagtctggaggacaggatcaggaacggaagaagacaaagcgaagg ggagacttgtattccatccagacctccctcatcgtggccgcactcaagaaaatgctgccc attggtttgaatatgtgcaccccaggcgatcaggagctgatctccctcgcgaaatcacga tacagctatagggacacagacgaagaggtgaaggaacatctgcggaataacttgcacttg caggaaaagtctgatgacccagctgtaaagtggcaactgaatctctacaaggatgtgttg aagagtgaagaaccttccaatccagaaaggacagtggagcgcgtgcagagaatttcagca gctgtcttccacctggagcaggtggagcagcctttgaggtccaagaaggcagtttggcac aaactgttgtcaaagcagcggaaacgggcagtggtggcctgtttcaggatggccccgctc tacaacctgcccaggcaccgctctattaacctcttcctccatggctatcagagattttgg atagaaacagaggagtatttctttgaagagaaactagtacaggatttggctaaatctccc aaggtggaagaggaggaggaagaggagacggaaaagcaaccagacccacttcatcagatc attctccattttagccgcaatgctctcacggagaggagtaaattggaagacgaccctttg tatacctcctattccagcatgatggccaagagttgtcagagtggggaggatgaagaagaa gaggaagacaaggaaaaaacattcgaagagaaagaaatggaaaagcagaaaacgctgtat cagcaggctcggctgcatgaacgcggagccgcagagatggtccttcagatgataagcgcc agtaaaggtgagatgagccccatggtggtcgagactctgaagctggggatcgctatcctg aatggaggcaacgctggtgtgcaacagaaaatgttagattacctcaaggagaaaaaggat gctggattctttcaaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaat gcatttgagaggcagaataaagctgaaggcctggggatggttacggaggaaggaacactc attgttcgtgaacgtggtgaaaaagtactccagaatgatgagtttacacgagacctcttt agattcctacagttactttgtgaaggacataacagcgactttcagaacttcctacggact caaatgggcaacaccaccactgtgaatgtcatcatcagcaccgtggactaccttctgcgt cttcaggaatcgatcagtgatttctactggtattattcagggaaggacatcattgacgaa tctggacagcacaatttttccaaagctctggcggtcaccaagcaaattttcaattctctt acagaatacatccagggcccttgcattgggaaccaacagagcctggctcacagcaggctg tgggacgcggtggtcggcttcctccatgtatttgctaacatgcagatgaaactctctcag gattccagtcagatcgagctgctgaaggaactcttggatctccttcaggacatggtggtg atgcttctgtccctcctggaaggaaatgtggtaaatggaactattggcaagcagatggtt gacacactggtagagtcatctaccaatgtagaaatgatcttgaaattctttgacatgttc ttgaaacttaaagacttaaccagctcagacaccttcaaagaatatgacccagatggcaaa gggattctctccaaaaaagaattccagaaggccatggaagggcaaaaacagtacacacag tcagagattgagtttctcctttcgtgtgcagaagctgatgagaatgacatgtttaattac attgattttgtggaccggttccacgagccggccaaggacatagggtttaacgtggcagtg ttattgacaaatctctccgagcatatgccaaatgattctcggcttaaatgtctgttggac ccagcagaaagtgtgctaaattacttcgaaccatacttaggacgcattgagattatgggc ggggccaagaaaattgagcgtgtttattttgagatcagtgaatccagtcgaactcagtgg gaaaagccccaagtgaaggaatctaagcgacagtttatctttgatgttgtcaacgaaggt ggggagcaagaaaaaatggaactgtttgtgaacttctgtgaagacaccatctttgaaatg cagttagcatcacagatctctgaatctgactcagccgacaggccagaagaagaggaggaa gatgaagattcttcttacacctcggaaattgagggtgaagaggaagataaaaagtccttt gagtctgcctctgcgttcgccatggcctgtgcctcagtgaagagaaacgttgccaacttt ctaaagagggcaaccctgaagaacctcaggaagcagtacaggaaggtgaaaaagatgact gtgaaggagctggtgcgggtgttcttctctttcttctggatgatgttcgtggggctattc caactgttcttcaccatactgggaggaatatttcagatcctctggaacacggtatttgga gggggcctggttgagggggcaaagaacatcagggtgaccaagatcctaggggacatgcct gacccgacccaatttggtatccacgatgatgctgtggaggccgagagggcagaagtgact gagccaggtatcaccactgaactagtacatttcataaagggtgagaagggaaatgcagat attatgtcagatctttttggattccactcaaaaaaagaaggtggcataaagcatgggccc gaagtgggtttgggtgacctctctgagattattggcaaggatgaaccccctacgctagag agtactgtacggaagaaaaggaaagcacaggcagcagagatgaaagcagcagatgaatca gaaggaaaagtagaacctgagaaggcagacatggaagatggggagaaggaggacacagcc agagaaggagagcaagccaaggccctgtgggcagaagtgaccaaaaagaagaagcgacgg cgtggccagaaagtcgagaagcctgaagccctcatggccaatttctttaaggggctggaa atctatcagaccaagttattgcactacttggccagaaatttctacaacctgaggttcctt gctctgtttgtagccttcgctatcaacttcatcctgctcttttacaaggtcactgaagaa cctttagaagaagaggcagaggacatcgcgaacctgtggcattcctttaatgacgaagaa gaggaagaagcgatggtgttctttgtcctgcaggagagcactgggtatatggcaccaaca ttgcgggctctggccgttatccacaccgtcatctctttagtctgcgtggtgggctattac tgcctgaaggtccctttggttgtattcaaaagggaaaaagaaattgccaggaagctggag tttgatggcctatatatcactgaacaaccatctgaagatgacatcaaggggcaatgggac cgcttggtaatcaacacaccatcttttcctaataactattgggacaagtttgtaaagaga aaggtgatcaacaagtatggagatctttatggagcagaacgcattgctgaactcctgggt ttggacaaaaatgcccttgactttagcccagtagaagagacgaaagcagaggcggcgtct ctagtgtcatggctaagttccatcgacatgaagtaccatatctggaagctaggagttgtt tttactgacaactcctttctctaccttgcctggtacacaaccatgtccatccttggccac tacaataacttcttcttcgctgctcatctgctggacatcgccatgggcttcaagacactg aggactattctgtcatctgtaactcacaatggcaaacagctggttttgactgtcggtctc ctggctgtggtggtttatctctacactgtggtggctttcaacttcttccgcaagttctac aacaagagtgaagatgatgatgagcccgatatgaagtgtgatgacatgatgacgtgttac ctattccacatgtacgtcggggtgagagctggaggcggcatcggcgatgaaatcgaagac cctgctggtgacccttatgaaatgtaccgcatcgtctttgacattacatttttcttcttc gtcattgtcatcttgctggccatcattcaaggtcttattattgatgcttttggagagcta agagaccagcaggaacaagtgagagaagatatggagactaaatgtttcatctgtgggatt ggcaatgattactttgacacgacgcctcatggttttgaaacacatacattacaagagcac aacttagccaactacttgttcttcctgatgtatctgattaacaaagatgaaacagagcac acgggtcaggaatcttatgtctggaagatgtaccaagaaaggtgttgggatttcttccca gctggtgactgctttcgaaaacaatatgaagatcagcttggataa

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