KEGG   Pteropus alecto (black flying fox): 102889227
Entry
102889227         CDS       T02993                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pale  Pteropus alecto (black flying fox)
Pathway
pale00562  Inositol phosphate metabolism
pale01100  Metabolic pathways
pale01521  EGFR tyrosine kinase inhibitor resistance
pale01522  Endocrine resistance
pale01524  Platinum drug resistance
pale04012  ErbB signaling pathway
pale04014  Ras signaling pathway
pale04015  Rap1 signaling pathway
pale04024  cAMP signaling pathway
pale04062  Chemokine signaling pathway
pale04066  HIF-1 signaling pathway
pale04068  FoxO signaling pathway
pale04070  Phosphatidylinositol signaling system
pale04071  Sphingolipid signaling pathway
pale04072  Phospholipase D signaling pathway
pale04081  Hormone signaling
pale04140  Autophagy - animal
pale04150  mTOR signaling pathway
pale04151  PI3K-Akt signaling pathway
pale04152  AMPK signaling pathway
pale04210  Apoptosis
pale04211  Longevity regulating pathway
pale04213  Longevity regulating pathway - multiple species
pale04218  Cellular senescence
pale04360  Axon guidance
pale04370  VEGF signaling pathway
pale04380  Osteoclast differentiation
pale04510  Focal adhesion
pale04517  IgSF CAM signaling
pale04550  Signaling pathways regulating pluripotency of stem cells
pale04611  Platelet activation
pale04613  Neutrophil extracellular trap formation
pale04620  Toll-like receptor signaling pathway
pale04625  C-type lectin receptor signaling pathway
pale04630  JAK-STAT signaling pathway
pale04650  Natural killer cell mediated cytotoxicity
pale04660  T cell receptor signaling pathway
pale04662  B cell receptor signaling pathway
pale04664  Fc epsilon RI signaling pathway
pale04666  Fc gamma R-mediated phagocytosis
pale04668  TNF signaling pathway
pale04670  Leukocyte transendothelial migration
pale04722  Neurotrophin signaling pathway
pale04725  Cholinergic synapse
pale04750  Inflammatory mediator regulation of TRP channels
pale04810  Regulation of actin cytoskeleton
pale04910  Insulin signaling pathway
pale04914  Progesterone-mediated oocyte maturation
pale04915  Estrogen signaling pathway
pale04917  Prolactin signaling pathway
pale04919  Thyroid hormone signaling pathway
pale04923  Regulation of lipolysis in adipocytes
pale04926  Relaxin signaling pathway
pale04929  GnRH secretion
pale04930  Type II diabetes mellitus
pale04931  Insulin resistance
pale04932  Non-alcoholic fatty liver disease
pale04933  AGE-RAGE signaling pathway in diabetic complications
pale04935  Growth hormone synthesis, secretion and action
pale04960  Aldosterone-regulated sodium reabsorption
pale04973  Carbohydrate digestion and absorption
pale05010  Alzheimer disease
pale05017  Spinocerebellar ataxia
pale05020  Prion disease
pale05100  Bacterial invasion of epithelial cells
pale05132  Salmonella infection
pale05135  Yersinia infection
pale05142  Chagas disease
pale05146  Amoebiasis
pale05160  Hepatitis C
pale05161  Hepatitis B
pale05162  Measles
pale05163  Human cytomegalovirus infection
pale05164  Influenza A
pale05165  Human papillomavirus infection
pale05166  Human T-cell leukemia virus 1 infection
pale05167  Kaposi sarcoma-associated herpesvirus infection
pale05168  Herpes simplex virus 1 infection
pale05169  Epstein-Barr virus infection
pale05170  Human immunodeficiency virus 1 infection
pale05171  Coronavirus disease - COVID-19
pale05200  Pathways in cancer
pale05203  Viral carcinogenesis
pale05205  Proteoglycans in cancer
pale05206  MicroRNAs in cancer
pale05207  Chemical carcinogenesis - receptor activation
pale05208  Chemical carcinogenesis - reactive oxygen species
pale05210  Colorectal cancer
pale05211  Renal cell carcinoma
pale05212  Pancreatic cancer
pale05213  Endometrial cancer
pale05214  Glioma
pale05215  Prostate cancer
pale05218  Melanoma
pale05220  Chronic myeloid leukemia
pale05221  Acute myeloid leukemia
pale05222  Small cell lung cancer
pale05223  Non-small cell lung cancer
pale05224  Breast cancer
pale05225  Hepatocellular carcinoma
pale05226  Gastric cancer
pale05230  Central carbon metabolism in cancer
pale05231  Choline metabolism in cancer
pale05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pale05415  Diabetic cardiomyopathy
pale05417  Lipid and atherosclerosis
pale05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pale00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102889227 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102889227 (PIK3CA)
   04014 Ras signaling pathway
    102889227 (PIK3CA)
   04015 Rap1 signaling pathway
    102889227 (PIK3CA)
   04370 VEGF signaling pathway
    102889227 (PIK3CA)
   04630 JAK-STAT signaling pathway
    102889227 (PIK3CA)
   04668 TNF signaling pathway
    102889227 (PIK3CA)
   04066 HIF-1 signaling pathway
    102889227 (PIK3CA)
   04068 FoxO signaling pathway
    102889227 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102889227 (PIK3CA)
   04072 Phospholipase D signaling pathway
    102889227 (PIK3CA)
   04071 Sphingolipid signaling pathway
    102889227 (PIK3CA)
   04024 cAMP signaling pathway
    102889227 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102889227 (PIK3CA)
   04152 AMPK signaling pathway
    102889227 (PIK3CA)
   04150 mTOR signaling pathway
    102889227 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102889227 (PIK3CA)
   04517 IgSF CAM signaling
    102889227 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102889227 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    102889227 (PIK3CA)
   04218 Cellular senescence
    102889227 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102889227 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    102889227 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102889227 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102889227 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    102889227 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102889227 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    102889227 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102889227 (PIK3CA)
   04660 T cell receptor signaling pathway
    102889227 (PIK3CA)
   04662 B cell receptor signaling pathway
    102889227 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102889227 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    102889227 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102889227 (PIK3CA)
   04062 Chemokine signaling pathway
    102889227 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102889227 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    102889227 (PIK3CA)
   04929 GnRH secretion
    102889227 (PIK3CA)
   04915 Estrogen signaling pathway
    102889227 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102889227 (PIK3CA)
   04917 Prolactin signaling pathway
    102889227 (PIK3CA)
   04926 Relaxin signaling pathway
    102889227 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    102889227 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102889227 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102889227 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102889227 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    102889227 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102889227 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102889227 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    102889227 (PIK3CA)
   04380 Osteoclast differentiation
    102889227 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    102889227 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    102889227 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102889227 (PIK3CA)
   05206 MicroRNAs in cancer
    102889227 (PIK3CA)
   05205 Proteoglycans in cancer
    102889227 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    102889227 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    102889227 (PIK3CA)
   05203 Viral carcinogenesis
    102889227 (PIK3CA)
   05230 Central carbon metabolism in cancer
    102889227 (PIK3CA)
   05231 Choline metabolism in cancer
    102889227 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102889227 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102889227 (PIK3CA)
   05212 Pancreatic cancer
    102889227 (PIK3CA)
   05225 Hepatocellular carcinoma
    102889227 (PIK3CA)
   05226 Gastric cancer
    102889227 (PIK3CA)
   05214 Glioma
    102889227 (PIK3CA)
   05221 Acute myeloid leukemia
    102889227 (PIK3CA)
   05220 Chronic myeloid leukemia
    102889227 (PIK3CA)
   05218 Melanoma
    102889227 (PIK3CA)
   05211 Renal cell carcinoma
    102889227 (PIK3CA)
   05215 Prostate cancer
    102889227 (PIK3CA)
   05213 Endometrial cancer
    102889227 (PIK3CA)
   05224 Breast cancer
    102889227 (PIK3CA)
   05222 Small cell lung cancer
    102889227 (PIK3CA)
   05223 Non-small cell lung cancer
    102889227 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102889227 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    102889227 (PIK3CA)
   05161 Hepatitis B
    102889227 (PIK3CA)
   05160 Hepatitis C
    102889227 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    102889227 (PIK3CA)
   05164 Influenza A
    102889227 (PIK3CA)
   05162 Measles
    102889227 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    102889227 (PIK3CA)
   05163 Human cytomegalovirus infection
    102889227 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102889227 (PIK3CA)
   05169 Epstein-Barr virus infection
    102889227 (PIK3CA)
   05165 Human papillomavirus infection
    102889227 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102889227 (PIK3CA)
   05135 Yersinia infection
    102889227 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    102889227 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102889227 (PIK3CA)
   05142 Chagas disease
    102889227 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102889227 (PIK3CA)
   05017 Spinocerebellar ataxia
    102889227 (PIK3CA)
   05020 Prion disease
    102889227 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102889227 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    102889227 (PIK3CA)
   05415 Diabetic cardiomyopathy
    102889227 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102889227 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    102889227 (PIK3CA)
   04931 Insulin resistance
    102889227 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102889227 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102889227 (PIK3CA)
   01524 Platinum drug resistance
    102889227 (PIK3CA)
   01522 Endocrine resistance
    102889227 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pale04131]
    102889227 (PIK3CA)
Enzymes [BR:pale01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102889227 (PIK3CA)
Membrane trafficking [BR:pale04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102889227 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 102889227
NCBI-ProteinID: XP_006910914
UniProt: L5KPB2
LinkDB
Position
Unknown
AA seq 1069 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWL
KFSSVKFPDMSVIEEHANWSVSREAGFSYAHAGLSNRLARDNELRENDKEQLRAICTRDP
LSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAM
ELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT
NQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDIL
KQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPL
WLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCL
SIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTR
SCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQD
FLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI
AYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3210 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactttttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctctttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
attggcatgccagtatgtgaattcgatatggttaaagatccagaagttcaggacttccga
aggaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaactcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcacctgaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaatcatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgttatcatctgaacaactaaaa
ctttgtgttttagaatatcagggcaaatatattttaaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactctcaactgccaatggac
tgttttacaatgccgtcttattccagacgtatctccacagctacaccgtatatgaatgga
gaaacatctacaaaatccctttgggttataaatagcgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctacgttagaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgagtggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacattgc
ccattggcctggggaaatataaatttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttactgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggtta
aaattcagcagtgtaaagtttccagatatgtcagtgattgaagagcatgccaattggtct
gtgtcccgagaagcaggatttagttatgcccacgcaggactgagtaacagactagccaga
gacaacgaattaagggaaaatgataaagaacagctccgagcaatttgtacccgagatcct
ctatctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgta
actatccctgaaattctacctaaattgcttctctccgttaaatggaattctagagatgaa
gtagctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatg
gagcttctagactgcaactacccagatcctatggttcgaggctttgctgttcgatgcttg
gaaaaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtccta
aaatatgaacagtatttggataacttgcttgtgagatttttactcaagaaagcattgact
aatcaaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaaca
gttagtcagagatttggcctacttttggagtcctattgtcgtgcatgtggaatgtatttg
aagcacctgaataggcaagttgaggctatggaaaagctcattaacttaactgacattctc
aaacaagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatg
cggcgaccagatttcatggatgctctgcagggctttctatctcctctaaaccctgctcat
caactaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactg
tggttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatc
atcttcaaaaatggggatgatttacggcaagatatgctaacacttcaaattatccgcatt
atggaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccatatggatgtctg
tcaattggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaa
attcagtgcaaaggcggcctgaaaggtgcactgcagttcaacagccacacactacatcag
tggctcaaagacaagaacaaaggagaaatatacgatgcagccattgatctgtttacacgt
tcatgcgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagt
aacatcatggttaaagatgatggacaactgtttcatatagattttggacactttttggat
cacaagaagaaaaaatttggctataaacgagagcgcgtgccatttgttttgactcaagat
ttcttgatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgaaagg
tttcaggaaatgtgttacaaagcttatctagctattcggcagcatgccaatctcttcata
aatcttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatatt
gcatacattcgaaagaccctagctttagataaaactgaacaagaagctttggaatatttc
atgaaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttc
cacacaattaagcagcatgctttgaactga

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