KEGG   Pteropus alecto (black flying fox): 102897122
Entry
102897122         CDS       T02993                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pale  Pteropus alecto (black flying fox)
Pathway
pale01521  EGFR tyrosine kinase inhibitor resistance
pale01522  Endocrine resistance
pale04010  MAPK signaling pathway
pale04012  ErbB signaling pathway
pale04014  Ras signaling pathway
pale04015  Rap1 signaling pathway
pale04022  cGMP-PKG signaling pathway
pale04024  cAMP signaling pathway
pale04062  Chemokine signaling pathway
pale04066  HIF-1 signaling pathway
pale04068  FoxO signaling pathway
pale04071  Sphingolipid signaling pathway
pale04072  Phospholipase D signaling pathway
pale04114  Oocyte meiosis
pale04140  Autophagy - animal
pale04148  Efferocytosis
pale04150  mTOR signaling pathway
pale04151  PI3K-Akt signaling pathway
pale04210  Apoptosis
pale04218  Cellular senescence
pale04270  Vascular smooth muscle contraction
pale04370  VEGF signaling pathway
pale04371  Apelin signaling pathway
pale04380  Osteoclast differentiation
pale04510  Focal adhesion
pale04517  IgSF CAM signaling
pale04540  Gap junction
pale04550  Signaling pathways regulating pluripotency of stem cells
pale04613  Neutrophil extracellular trap formation
pale04620  Toll-like receptor signaling pathway
pale04650  Natural killer cell mediated cytotoxicity
pale04660  T cell receptor signaling pathway
pale04662  B cell receptor signaling pathway
pale04664  Fc epsilon RI signaling pathway
pale04666  Fc gamma R-mediated phagocytosis
pale04668  TNF signaling pathway
pale04720  Long-term potentiation
pale04722  Neurotrophin signaling pathway
pale04725  Cholinergic synapse
pale04726  Serotonergic synapse
pale04730  Long-term depression
pale04810  Regulation of actin cytoskeleton
pale04910  Insulin signaling pathway
pale04912  GnRH signaling pathway
pale04914  Progesterone-mediated oocyte maturation
pale04915  Estrogen signaling pathway
pale04916  Melanogenesis
pale04917  Prolactin signaling pathway
pale04919  Thyroid hormone signaling pathway
pale04921  Oxytocin signaling pathway
pale04926  Relaxin signaling pathway
pale04928  Parathyroid hormone synthesis, secretion and action
pale04929  GnRH secretion
pale04934  Cushing syndrome
pale04935  Growth hormone synthesis, secretion and action
pale05010  Alzheimer disease
pale05022  Pathways of neurodegeneration - multiple diseases
pale05034  Alcoholism
pale05132  Salmonella infection
pale05135  Yersinia infection
pale05160  Hepatitis C
pale05161  Hepatitis B
pale05163  Human cytomegalovirus infection
pale05164  Influenza A
pale05165  Human papillomavirus infection
pale05166  Human T-cell leukemia virus 1 infection
pale05167  Kaposi sarcoma-associated herpesvirus infection
pale05170  Human immunodeficiency virus 1 infection
pale05200  Pathways in cancer
pale05205  Proteoglycans in cancer
pale05206  MicroRNAs in cancer
pale05207  Chemical carcinogenesis - receptor activation
pale05208  Chemical carcinogenesis - reactive oxygen species
pale05210  Colorectal cancer
pale05211  Renal cell carcinoma
pale05212  Pancreatic cancer
pale05213  Endometrial cancer
pale05214  Glioma
pale05215  Prostate cancer
pale05216  Thyroid cancer
pale05218  Melanoma
pale05219  Bladder cancer
pale05220  Chronic myeloid leukemia
pale05221  Acute myeloid leukemia
pale05223  Non-small cell lung cancer
pale05224  Breast cancer
pale05225  Hepatocellular carcinoma
pale05226  Gastric cancer
pale05230  Central carbon metabolism in cancer
pale05231  Choline metabolism in cancer
pale05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pale00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102897122 (MAP2K1)
   04012 ErbB signaling pathway
    102897122 (MAP2K1)
   04014 Ras signaling pathway
    102897122 (MAP2K1)
   04015 Rap1 signaling pathway
    102897122 (MAP2K1)
   04370 VEGF signaling pathway
    102897122 (MAP2K1)
   04371 Apelin signaling pathway
    102897122 (MAP2K1)
   04668 TNF signaling pathway
    102897122 (MAP2K1)
   04066 HIF-1 signaling pathway
    102897122 (MAP2K1)
   04068 FoxO signaling pathway
    102897122 (MAP2K1)
   04072 Phospholipase D signaling pathway
    102897122 (MAP2K1)
   04071 Sphingolipid signaling pathway
    102897122 (MAP2K1)
   04024 cAMP signaling pathway
    102897122 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    102897122 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    102897122 (MAP2K1)
   04150 mTOR signaling pathway
    102897122 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    102897122 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102897122 (MAP2K1)
   04148 Efferocytosis
    102897122 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102897122 (MAP2K1)
   04210 Apoptosis
    102897122 (MAP2K1)
   04218 Cellular senescence
    102897122 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102897122 (MAP2K1)
   04540 Gap junction
    102897122 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102897122 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102897122 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102897122 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    102897122 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    102897122 (MAP2K1)
   04660 T cell receptor signaling pathway
    102897122 (MAP2K1)
   04662 B cell receptor signaling pathway
    102897122 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    102897122 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    102897122 (MAP2K1)
   04062 Chemokine signaling pathway
    102897122 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102897122 (MAP2K1)
   04929 GnRH secretion
    102897122 (MAP2K1)
   04912 GnRH signaling pathway
    102897122 (MAP2K1)
   04915 Estrogen signaling pathway
    102897122 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    102897122 (MAP2K1)
   04917 Prolactin signaling pathway
    102897122 (MAP2K1)
   04921 Oxytocin signaling pathway
    102897122 (MAP2K1)
   04926 Relaxin signaling pathway
    102897122 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    102897122 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    102897122 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    102897122 (MAP2K1)
   04916 Melanogenesis
    102897122 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102897122 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    102897122 (MAP2K1)
   04726 Serotonergic synapse
    102897122 (MAP2K1)
   04720 Long-term potentiation
    102897122 (MAP2K1)
   04730 Long-term depression
    102897122 (MAP2K1)
   04722 Neurotrophin signaling pathway
    102897122 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102897122 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102897122 (MAP2K1)
   05206 MicroRNAs in cancer
    102897122 (MAP2K1)
   05205 Proteoglycans in cancer
    102897122 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    102897122 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102897122 (MAP2K1)
   05230 Central carbon metabolism in cancer
    102897122 (MAP2K1)
   05231 Choline metabolism in cancer
    102897122 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102897122 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102897122 (MAP2K1)
   05212 Pancreatic cancer
    102897122 (MAP2K1)
   05225 Hepatocellular carcinoma
    102897122 (MAP2K1)
   05226 Gastric cancer
    102897122 (MAP2K1)
   05214 Glioma
    102897122 (MAP2K1)
   05216 Thyroid cancer
    102897122 (MAP2K1)
   05221 Acute myeloid leukemia
    102897122 (MAP2K1)
   05220 Chronic myeloid leukemia
    102897122 (MAP2K1)
   05218 Melanoma
    102897122 (MAP2K1)
   05211 Renal cell carcinoma
    102897122 (MAP2K1)
   05219 Bladder cancer
    102897122 (MAP2K1)
   05215 Prostate cancer
    102897122 (MAP2K1)
   05213 Endometrial cancer
    102897122 (MAP2K1)
   05224 Breast cancer
    102897122 (MAP2K1)
   05223 Non-small cell lung cancer
    102897122 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102897122 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    102897122 (MAP2K1)
   05161 Hepatitis B
    102897122 (MAP2K1)
   05160 Hepatitis C
    102897122 (MAP2K1)
   05164 Influenza A
    102897122 (MAP2K1)
   05163 Human cytomegalovirus infection
    102897122 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102897122 (MAP2K1)
   05165 Human papillomavirus infection
    102897122 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102897122 (MAP2K1)
   05135 Yersinia infection
    102897122 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102897122 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    102897122 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    102897122 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102897122 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102897122 (MAP2K1)
   01522 Endocrine resistance
    102897122 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pale01001]
    102897122 (MAP2K1)
Enzymes [BR:pale01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102897122 (MAP2K1)
Protein kinases [BR:pale01001]
 Serine/threonine kinases: STE group
  STE7 family
   102897122 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 102897122
NCBI-ProteinID: XP_006920300
UniProt: L5K149
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaatccagccccagacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctggatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggggaactgaaggatgacgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggtgttcaaggtctcccacaagccatccggcctggtcatggctagaaagttaattcac
ctggaaatcaaacctgcaatccggaaccagatcataagagagctgcaagttctacatgag
tgtaactctccgtacatcgtgggcttctatggtgcattttacagtgatggcgagatcagc
atctgcatggagcatatggatgggggttccttggatcaagtgctgaagaaagctggacga
attcctgaacaaattttaggaaaagttagcattgctgtaattaaaggtctgacgtatctg
agggagaagcacaagattatgcatagagatgtcaagccttctaacatcctagtgaactct
cgtggggagatcaagctttgtgactttggggtcagcgggcagcttatcgactccatggcc
aattccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcactac
tcggtgcagtcggacatctggagtatggggctctctctggttgagatggcagttgggagg
tatcccatccctcctccagatgccaaggagctggaactgatgtttgggtgccaagtggag
ggagatgcagctgagacaccgcctaggccaaggacccctgggaggcccctcagctcttat
ggaatggatagccgacctcccatggcaattttcgaattgttggattatatagttaatgag
cctcctccaaaactacccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagaaagagctgatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtagattttgcaggttggctctgctctaccattggc
cttaaccagcccagcacaccaacccatgcagctggtgtctaa

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