Pteropus alecto (black flying fox): 102897365 Help Entry 102897365         CDS       T02993                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4 precursor   KO K10160   toll-like receptor 4 Organism pale  Pteropus alecto (black flying fox) Pathway pale04064   NF-kappa B signaling pathway pale04066   HIF-1 signaling pathway pale04145   Phagosome pale04151   PI3K-Akt signaling pathway pale04217   Necroptosis pale04613   Neutrophil extracellular trap formation pale04620   Toll-like receptor signaling pathway pale04621   NOD-like receptor signaling pathway pale04936   Alcoholic liver disease pale05132   Salmonella infection pale05133   Pertussis pale05134   Legionellosis pale05135   Yersinia infection pale05140   Leishmaniasis pale05142   Chagas disease pale05144   Malaria pale05145   Toxoplasmosis pale05146   Amoebiasis pale05152   Tuberculosis pale05161   Hepatitis B pale05162   Measles pale05164   Influenza A pale05170   Human immunodeficiency virus 1 infection pale05171   Coronavirus disease - COVID-19 pale05205   Proteoglycans in cancer pale05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pale05321   Inflammatory bowel disease pale05323   Rheumatoid arthritis pale05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:pale00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     102897365 (TLR4)    04066 HIF-1 signaling pathway     102897365 (TLR4)    04151 PI3K-Akt signaling pathway     102897365 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     102897365 (TLR4)   09143 Cell growth and death    04217 Necroptosis     102897365 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     102897365 (TLR4)    04620 Toll-like receptor signaling pathway     102897365 (TLR4)    04621 NOD-like receptor signaling pathway     102897365 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     102897365 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102897365 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102897365 (TLR4)    05161 Hepatitis B     102897365 (TLR4)    05171 Coronavirus disease - COVID-19     102897365 (TLR4)    05164 Influenza A     102897365 (TLR4)    05162 Measles     102897365 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     102897365 (TLR4)    05135 Yersinia infection     102897365 (TLR4)    05133 Pertussis     102897365 (TLR4)    05134 Legionellosis     102897365 (TLR4)    05152 Tuberculosis     102897365 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     102897365 (TLR4)    05144 Malaria     102897365 (TLR4)    05145 Toxoplasmosis     102897365 (TLR4)    05140 Leishmaniasis     102897365 (TLR4)    05142 Chagas disease     102897365 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     102897365 (TLR4)    05321 Inflammatory bowel disease     102897365 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102897365 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     102897365 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pale04131]     102897365 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:pale04054]     102897365 (TLR4)    04090 CD molecules [BR:pale04090]     102897365 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:pale00536]     102897365 (TLR4) Membrane trafficking [BR:pale04131]  Endocytosis   Phagocytosis    Toll-like receptors     102897365 (TLR4) Pattern recognition receptors [BR:pale04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    102897365 (TLR4) CD molecules [BR:pale04090]  Proteins   102897365 (TLR4) Glycosaminoglycan binding proteins [BR:pale00536]  Hyaluronan   Cell surface receptors    102897365 (TLR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LRR_8 TIR LRR_4 LRR_1 TIR_2 LRR_9 LRR_5 LRR_NXF1-5 LRR_LRWD1 LRR_EndoS LRR_Zer-1 LRR_R13L1-DRL21 Curto_V2 ThsB_TIR Motif Other DBs NCBI-GeneID:  102897365 NCBI-ProteinID:  NP_001277101 UniProt:  E2DIE7 LinkDB All DBs AA seq 841 aa AA seqDB search MMPPTRLAGILIPAMAFLSCLRPESWDPCVRVVPHITYQCMELNLYKIPNNIPTSVKKLD LSFNPLRRLSSHIFSNFSELQVLDLSRCEIEMIEDDAYEGLNHLSTLVLTGNPIQSLAMG AFSGLSSLQTLVAVEINLVSLEDFPIGHLKTLKELNVAHNLIDSFKLPEYFSNLSDLEHL DLSNNKIQTICHKDLQVLHQMPPSKLSLDLSLNPLDFIQRGAFKEIKLHELTLRSNFNST DVMKTCVQGLAGLKINRLVLGEFKNERAIKHFDKSAMEGLCNLTIDEFRMTYFDDFSEDV INFFNCLANVSTISLVGLYLNRLEVLSKDFKWQHLKLTNSKFDHFPRLELDSLKKLVFTA NRGMSTFTEVKLPKLEFLDLSRNSLSFKSCCSRTFWGTTRLKHLDLSFNDVITMSSNSLG LEQLKYLDFQHSNLKQASDFSVFLSLKNLLYLDISYTRIRIIFHGIFDGLFSLEVLKMAG NSFQDNSVPNIFKALTNLTFLDLSNCQLERVSQAAFGSLVKLKSLNMSHNHLLSLDLFPY KLPHSLQDLDCSFNRIVASNRQELQHFPSNLTSLNLTGNDFACICEHQSFLQWVKDHRHL LVGVTQMVCVKPLDMQGVPVLSFRNATCPMSKTVISVSVLTVLVVSVVAVLVYKFYFHLM LLAGCKKYGRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYGIAQTWQFLSSRAGIIFIVLQKVEKSLL RQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKLWSPEGAADAESSQHEATIT I NT seq 2526 nt NT seq  +upstreamnt  +downstreamnt atgatgcctcccacccgcctggctgggattctgatcccagccatggcctttctttcctgc ctgagacctgagagctgggacccttgcgtgcgggtggttcctcacattacctaccagtgc atggagctgaatctctacaaaatccccaacaacatccccacatcagtcaagaaactggat ctgagctttaaccccctgagacgtctaagcagccatatcttctccaacttctcagaattg caggtgctggatttatctaggtgtgaaattgagatgattgaagatgatgcatatgagggt ctaaaccatctctccaccttggtattgacaggaaaccctatccagagtttagccatggga gccttttctggactatcaagtttacagacactggtggctgtggagataaacctagtgtct ctagaggacttccccattggacacctgaaaaccttgaaggagcttaatgtggctcacaat cttattgattccttcaagttacctgaatatttttctaacctgtccgacctggagcactta gacctttccaataacaagatccaaactatttgtcataaagacctacaggttctacatcaa atgcccccatccaaactctctttagacttgtccctgaaccctttagacttcatccaacga ggtgcctttaaagaaattaagctccatgaactaactttgagaagtaattttaacagtaca gatgtaatgaaaacttgtgttcaaggcctcgctggcttaaaaatcaatcgtttggttcta ggagaatttaaaaatgaaagagccataaaacattttgacaaatctgccatggagggactg tgcaatttgaccattgacgaattccggatgacatacttcgatgacttctcagaggatgtt attaacttttttaattgtttggcaaatgtttctacaatttctctggtgggtctgtattta aacaggctagaagtcctttctaaagatttcaaatggcaacacttaaaactgactaattct aaatttgatcattttcccaggttggaacttgactctctcaaaaagttggttttcactgcc aacaggggtatgagcacttttactgaagttaaactaccaaaacttgagtttctagatctc agtagaaatagtttgagtttcaagagttgctgttctcgcactttttgggggacaactaga ctgaaacacttagatctgagctttaatgatgttattaccatgagctcaaactccttgggc ttagagcaactaaaatatctggatttccagcattccaatttgaaacaggccagtgatttt tcggtattcctatcactcaaaaacctactttaccttgatatttcttatactcgcatccga atcatcttccatggcatctttgacggcttgttcagcctcgaagtcttgaaaatggctggc aattcttttcaggacaactccgttccaaatatcttcaaagcgctgactaacttaaccttc ctggacctctctaattgccagctagaacgagtgtcccaggcggcatttggctcactcgtt aaacttaagtcactaaatatgagtcacaaccaccttttatccttggatctatttccttat aaacttccccactctctccaggatctggactgcagttttaatcgcatagtggcctccaat aggcaagaactacagcattttccaagtaatctaacttccttaaatctcactgggaatgac tttgcttgcatttgtgaacaccagagttttctgcagtgggtcaaggaccacaggcacctc ttggtgggagttacacaaatggtgtgtgtgaaacctttagatatgcagggtgtgcctgta ctcagttttagaaatgccacctgtccgatgagcaagactgtcattagtgtgtcggttctc actgtgcttgtggtatctgtggtagcagttctggtttataagttctatttccacctgatg cttcttgctggctgcaaaaagtatggcagaggtgaaagcacctatgatgcctttgttatt tactcaagccaggatgaggactgggtgaggaatgagttggtaaagaacttggaggagggg gtgcccccctttcagctctgccttcactacagagactttattcctggtgtggccattgct gccaacatcatccaagaaggtttccacaagagccgaaaggttatcgtcgtggtgtcccag cacttcatccagagccgatggtgtatttttgagtatgggattgcccagacctggcagttt ctgagcagtcgtgcgggcatcatcttcattgtcctacagaaggtggagaagtccctgctc cggcagcaggtggagctgtatcgccttctcagcaggaacacttacctggagtgggaggac agtgtcctcgggcggcacatcttctggagacgactcagaaaagccttgctagatggcaaa ctgtggagtccagaaggagcagcagatgcagaaagcagccagcatgaagcaacaatcact atctga

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