KEGG   Papio anubis (olive baboon): 101008699
Entry
101008699         CDS       T07474                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
panu  Papio anubis (olive baboon)
Pathway
panu00562  Inositol phosphate metabolism
panu01100  Metabolic pathways
panu01521  EGFR tyrosine kinase inhibitor resistance
panu01522  Endocrine resistance
panu01524  Platinum drug resistance
panu04012  ErbB signaling pathway
panu04014  Ras signaling pathway
panu04015  Rap1 signaling pathway
panu04024  cAMP signaling pathway
panu04062  Chemokine signaling pathway
panu04066  HIF-1 signaling pathway
panu04068  FoxO signaling pathway
panu04070  Phosphatidylinositol signaling system
panu04071  Sphingolipid signaling pathway
panu04072  Phospholipase D signaling pathway
panu04081  Hormone signaling
panu04140  Autophagy - animal
panu04150  mTOR signaling pathway
panu04151  PI3K-Akt signaling pathway
panu04152  AMPK signaling pathway
panu04210  Apoptosis
panu04211  Longevity regulating pathway
panu04213  Longevity regulating pathway - multiple species
panu04218  Cellular senescence
panu04360  Axon guidance
panu04370  VEGF signaling pathway
panu04380  Osteoclast differentiation
panu04510  Focal adhesion
panu04517  IgSF CAM signaling
panu04518  Integrin signaling
panu04550  Signaling pathways regulating pluripotency of stem cells
panu04611  Platelet activation
panu04613  Neutrophil extracellular trap formation
panu04620  Toll-like receptor signaling pathway
panu04625  C-type lectin receptor signaling pathway
panu04630  JAK-STAT signaling pathway
panu04650  Natural killer cell mediated cytotoxicity
panu04660  T cell receptor signaling pathway
panu04662  B cell receptor signaling pathway
panu04664  Fc epsilon RI signaling pathway
panu04666  Fc gamma R-mediated phagocytosis
panu04668  TNF signaling pathway
panu04670  Leukocyte transendothelial migration
panu04722  Neurotrophin signaling pathway
panu04725  Cholinergic synapse
panu04750  Inflammatory mediator regulation of TRP channels
panu04810  Regulation of actin cytoskeleton
panu04910  Insulin signaling pathway
panu04914  Progesterone-mediated oocyte maturation
panu04915  Estrogen signaling pathway
panu04917  Prolactin signaling pathway
panu04919  Thyroid hormone signaling pathway
panu04923  Regulation of lipolysis in adipocytes
panu04926  Relaxin signaling pathway
panu04929  GnRH secretion
panu04930  Type II diabetes mellitus
panu04931  Insulin resistance
panu04932  Non-alcoholic fatty liver disease
panu04933  AGE-RAGE signaling pathway in diabetic complications
panu04935  Growth hormone synthesis, secretion and action
panu04960  Aldosterone-regulated sodium reabsorption
panu04973  Carbohydrate digestion and absorption
panu05010  Alzheimer disease
panu05017  Spinocerebellar ataxia
panu05020  Prion disease
panu05100  Bacterial invasion of epithelial cells
panu05132  Salmonella infection
panu05135  Yersinia infection
panu05142  Chagas disease
panu05146  Amoebiasis
panu05160  Hepatitis C
panu05161  Hepatitis B
panu05162  Measles
panu05163  Human cytomegalovirus infection
panu05164  Influenza A
panu05165  Human papillomavirus infection
panu05166  Human T-cell leukemia virus 1 infection
panu05167  Kaposi sarcoma-associated herpesvirus infection
panu05168  Herpes simplex virus 1 infection
panu05169  Epstein-Barr virus infection
panu05170  Human immunodeficiency virus 1 infection
panu05171  Coronavirus disease - COVID-19
panu05200  Pathways in cancer
panu05203  Viral carcinogenesis
panu05205  Proteoglycans in cancer
panu05206  MicroRNAs in cancer
panu05207  Chemical carcinogenesis - receptor activation
panu05208  Chemical carcinogenesis - reactive oxygen species
panu05210  Colorectal cancer
panu05211  Renal cell carcinoma
panu05212  Pancreatic cancer
panu05213  Endometrial cancer
panu05214  Glioma
panu05215  Prostate cancer
panu05218  Melanoma
panu05220  Chronic myeloid leukemia
panu05221  Acute myeloid leukemia
panu05222  Small cell lung cancer
panu05223  Non-small cell lung cancer
panu05224  Breast cancer
panu05225  Hepatocellular carcinoma
panu05226  Gastric cancer
panu05230  Central carbon metabolism in cancer
panu05231  Choline metabolism in cancer
panu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
panu05415  Diabetic cardiomyopathy
panu05417  Lipid and atherosclerosis
panu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:panu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101008699 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101008699 (PIK3CB)
   04014 Ras signaling pathway
    101008699 (PIK3CB)
   04015 Rap1 signaling pathway
    101008699 (PIK3CB)
   04370 VEGF signaling pathway
    101008699 (PIK3CB)
   04630 JAK-STAT signaling pathway
    101008699 (PIK3CB)
   04668 TNF signaling pathway
    101008699 (PIK3CB)
   04066 HIF-1 signaling pathway
    101008699 (PIK3CB)
   04068 FoxO signaling pathway
    101008699 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    101008699 (PIK3CB)
   04072 Phospholipase D signaling pathway
    101008699 (PIK3CB)
   04071 Sphingolipid signaling pathway
    101008699 (PIK3CB)
   04024 cAMP signaling pathway
    101008699 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    101008699 (PIK3CB)
   04152 AMPK signaling pathway
    101008699 (PIK3CB)
   04150 mTOR signaling pathway
    101008699 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101008699 (PIK3CB)
   04517 IgSF CAM signaling
    101008699 (PIK3CB)
   04518 Integrin signaling
    101008699 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101008699 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    101008699 (PIK3CB)
   04218 Cellular senescence
    101008699 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101008699 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    101008699 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101008699 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101008699 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    101008699 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    101008699 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    101008699 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    101008699 (PIK3CB)
   04660 T cell receptor signaling pathway
    101008699 (PIK3CB)
   04662 B cell receptor signaling pathway
    101008699 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    101008699 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    101008699 (PIK3CB)
   04670 Leukocyte transendothelial migration
    101008699 (PIK3CB)
   04062 Chemokine signaling pathway
    101008699 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101008699 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    101008699 (PIK3CB)
   04929 GnRH secretion
    101008699 (PIK3CB)
   04915 Estrogen signaling pathway
    101008699 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    101008699 (PIK3CB)
   04917 Prolactin signaling pathway
    101008699 (PIK3CB)
   04926 Relaxin signaling pathway
    101008699 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    101008699 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    101008699 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101008699 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101008699 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    101008699 (PIK3CB)
   04722 Neurotrophin signaling pathway
    101008699 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101008699 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    101008699 (PIK3CB)
   04380 Osteoclast differentiation
    101008699 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    101008699 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    101008699 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101008699 (PIK3CB)
   05206 MicroRNAs in cancer
    101008699 (PIK3CB)
   05205 Proteoglycans in cancer
    101008699 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    101008699 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    101008699 (PIK3CB)
   05203 Viral carcinogenesis
    101008699 (PIK3CB)
   05230 Central carbon metabolism in cancer
    101008699 (PIK3CB)
   05231 Choline metabolism in cancer
    101008699 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101008699 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101008699 (PIK3CB)
   05212 Pancreatic cancer
    101008699 (PIK3CB)
   05225 Hepatocellular carcinoma
    101008699 (PIK3CB)
   05226 Gastric cancer
    101008699 (PIK3CB)
   05214 Glioma
    101008699 (PIK3CB)
   05221 Acute myeloid leukemia
    101008699 (PIK3CB)
   05220 Chronic myeloid leukemia
    101008699 (PIK3CB)
   05218 Melanoma
    101008699 (PIK3CB)
   05211 Renal cell carcinoma
    101008699 (PIK3CB)
   05215 Prostate cancer
    101008699 (PIK3CB)
   05213 Endometrial cancer
    101008699 (PIK3CB)
   05224 Breast cancer
    101008699 (PIK3CB)
   05222 Small cell lung cancer
    101008699 (PIK3CB)
   05223 Non-small cell lung cancer
    101008699 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101008699 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    101008699 (PIK3CB)
   05161 Hepatitis B
    101008699 (PIK3CB)
   05160 Hepatitis C
    101008699 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    101008699 (PIK3CB)
   05164 Influenza A
    101008699 (PIK3CB)
   05162 Measles
    101008699 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    101008699 (PIK3CB)
   05163 Human cytomegalovirus infection
    101008699 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101008699 (PIK3CB)
   05169 Epstein-Barr virus infection
    101008699 (PIK3CB)
   05165 Human papillomavirus infection
    101008699 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101008699 (PIK3CB)
   05135 Yersinia infection
    101008699 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    101008699 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101008699 (PIK3CB)
   05142 Chagas disease
    101008699 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101008699 (PIK3CB)
   05017 Spinocerebellar ataxia
    101008699 (PIK3CB)
   05020 Prion disease
    101008699 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101008699 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    101008699 (PIK3CB)
   05415 Diabetic cardiomyopathy
    101008699 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101008699 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    101008699 (PIK3CB)
   04931 Insulin resistance
    101008699 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101008699 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101008699 (PIK3CB)
   01524 Platinum drug resistance
    101008699 (PIK3CB)
   01522 Endocrine resistance
    101008699 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:panu04131]
    101008699 (PIK3CB)
Enzymes [BR:panu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101008699 (PIK3CB)
Membrane trafficking [BR:panu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101008699 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 101008699
NCBI-ProteinID: XP_009199882
Ensembl: ENSPANG00000009667
UniProt: A0A096NG14
LinkDB
Position
2:152833709..153019771
AA seq 1070 aa
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAIHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaactacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaaccagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaagatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcattgtagct
attcattttgaaaactgccaggatgtgtttagctttcaagtatctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagtgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtaatgaacaggaccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggaaatgattgccata
gaggctgccataaatcggaattcatctaaccttcctcttccattaccaccaaagaaaacg
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgaactcctgtgtaaaaccatcgtaagctcagaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgccgttttggataaagtaaaaacgaagaaatcaacgaaaactatt
aatccctctaaatatcagaccatcagaaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatattaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggctgctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagattttcccacaatcgttgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcagtatctgtta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttctaaacaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcagtgaagttaaacagagccaaagggaaggag
gccatgcatacttgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcggaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccagatgttg
cgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttacactgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgacggcatgggaatcttttc
atcactctctttgcgctgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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