KEGG   PATHWAY: bbrd01210
Entry
bbrd01210                   Pathway                                
Name
2-Oxocarboxylic acid metabolism - Bifidobacterium breve DSM 20213 = JCM 1192
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
bbrd01210  2-Oxocarboxylic acid metabolism
bbrd01210

Module
bbrd_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:bbrd01210]
bbrd_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:bbrd01210]
bbrd_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:bbrd01210]
bbrd_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:bbrd01210]
Organism
Bifidobacterium breve DSM 20213 = JCM 1192 [GN:bbrd]
Related
pathway
bbrd00020  Citrate cycle (TCA cycle)
bbrd00220  Arginine biosynthesis
bbrd00250  Alanine, aspartate and glutamate metabolism
bbrd00260  Glycine, serine and threonine metabolism
bbrd00270  Cysteine and methionine metabolism
bbrd00290  Valine, leucine and isoleucine biosynthesis
bbrd00300  Lysine biosynthesis
bbrd00310  Lysine degradation
bbrd00620  Pyruvate metabolism
bbrd00640  Propanoate metabolism
bbrd00680  Methane metabolism
KO pathway
ko01210   
LinkDB

DBGET integrated database retrieval system