KEGG   PATHWAY: cbk02030
Entry
cbk02030                    Pathway                                
Name
Bacterial chemotaxis - Clostridium botulinum B Eklund 17B (NRP)
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
Pathway map
cbk02030  Bacterial chemotaxis
cbk02030

Other DBs
GO: 0006935
Organism
Clostridium botulinum B Eklund 17B (NRP) [GN:cbk]
Gene
CLL_A0061  methyl-accepting chemotaxis sensory transducer [KO:K03406]
CLL_A1067  methyl-accepting chemotaxis protein [KO:K03406]
CLL_A0667  methyl-accepting chemotaxis protein [KO:K03406]
CLL_A1855  methyl-accepting chemotaxis protein [KO:K03406]
CLL_A2652  methyl-accepting chemotaxis protein [KO:K03406]
CLL_A2195  methyl-accepting chemotaxis protein [KO:K03406]
CLL_A2996  methyl-accepting chemotaxis sensory transducer [KO:K03406]
CLL_A1972  methyl-accepting chemotaxis sensory transducer [KO:K03406]
CLL_A3150  methyl-accepting chemotaxis protein [KO:K03406]
CLL_A3212  putative methyl-accepting chemotaxis protein [KO:K03406]
CLL_A3277  methyl-accepting chemotaxis protein [KO:K03406]
CLL_A1019  HAMP/methyl-accepting chemotaxis signalling domain protein [KO:K03406]
CLL_A1531  D-ribose-binding protein [KO:K10439]
CLL_A2524  D-galactose-binding periplasmic protein [KO:K10540]
CLL_A2600  D-galactose-binding periplasmic protein [KO:K10540]
CLL_A0800  cheA; chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
CLL_A0803  chemotaxis signal transduction protein CheW [KO:K03408]
CLL_A0796  cheW; chemotaxis protein CheW [KO:K03408]
CLL_A0802  cheY; chemotaxis protein CheY [KO:K03413]
CLL_A0801  cheC; chemotaxis protein CheC [KO:K03410]
CLL_A0798  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
CLL_A1563  cheV; chemotaxis protein CheV [KO:K03415]
CLL_A0797  chemoreceptor glutamine deamidase CheD [KO:K03411] [EC:3.5.1.44]
CLL_A0799  cheR; chemotaxis protein methyltransferase, CheR [KO:K00575] [EC:2.1.1.80]
CLL_A0841  fliG; flagellar motor switch protein FliG [KO:K02410]
CLL_A0804  fliM; flagellar motor switch protein FliM [KO:K02416]
CLL_A0805  fliN; flagellar motor switch protein FliN [KO:K02417]
CLL_A3510  putative chemotaxis protein MotA [KO:K02556]
CLL_A0851  motA; chemotaxis protein MotA [KO:K02556]
CLL_A0852  motB; chemotaxis protein MotB [KO:K02557]
CLL_A3509  putative chemotaxis MotB protein [KO:K02557]
Compound
C00049  L-Aspartate
C00107  Dipeptide
C00121  D-Ribose
C00124  D-Galactose
C00208  Maltose
C00716  Serine
Reference
PMID:12011078
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
DOI:10.1074/jbc.M201334200
Reference
PMID:11722727
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
DOI:10.1046/j.1365-2958.2001.02581.x
Reference
PMID:12920116
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
DOI:10.1074/jbc.M306180200
Reference
PMID:14749334
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
DOI:10.1074/jbc.M311497200
Reference
PMID:11158445
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
DOI:10.1093/pcp/pce007
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
DOI:10.1128/JB.175.18.5934-5944.1993
Reference
PMID:15187186
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
DOI:10.1128/MMBR.68.2.301-319.2004
Reference
PMID:18774298
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
DOI:10.1016/j.tim.2008.07.003
Reference
PMID:18990184
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
DOI:10.1111/j.1365-2958.2008.06482.x
Reference
PMID:19203648
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Related
pathway
cbk02040  Flagellar assembly
KO pathway
ko02030   
LinkDB

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