KEGG   PATHWAY: cbq01210
Entry
cbq01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Lawsonella clevelandensis
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
cbq01210  2-Oxocarboxylic acid metabolism
cbq01210

Module
cbq_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:cbq01210]
cbq_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:cbq01210]
cbq_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:cbq01210]
cbq_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:cbq01210]
Organism
Lawsonella clevelandensis [GN:cbq]
Related
pathway
cbq00020  Citrate cycle (TCA cycle)
cbq00220  Arginine biosynthesis
cbq00250  Alanine, aspartate and glutamate metabolism
cbq00260  Glycine, serine and threonine metabolism
cbq00270  Cysteine and methionine metabolism
cbq00290  Valine, leucine and isoleucine biosynthesis
cbq00300  Lysine biosynthesis
cbq00310  Lysine degradation
cbq00620  Pyruvate metabolism
cbq00640  Propanoate metabolism
cbq00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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