KEGG   PATHWAY: ccax01210
Entry
ccax01210                   Pathway                                
Name
2-Oxocarboxylic acid metabolism - Cupriavidus cauae
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
ccax01210  2-Oxocarboxylic acid metabolism
ccax01210

Module
ccax_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:ccax01210]
ccax_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:ccax01210]
ccax_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ccax01210]
ccax_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:ccax01210]
ccax_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:ccax01210]
ccax_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ccax01210]
Organism
Cupriavidus cauae [GN:ccax]
Related
pathway
ccax00020  Citrate cycle (TCA cycle)
ccax00220  Arginine biosynthesis
ccax00250  Alanine, aspartate and glutamate metabolism
ccax00260  Glycine, serine and threonine metabolism
ccax00270  Cysteine and methionine metabolism
ccax00290  Valine, leucine and isoleucine biosynthesis
ccax00300  Lysine biosynthesis
ccax00310  Lysine degradation
ccax00620  Pyruvate metabolism
ccax00640  Propanoate metabolism
ccax00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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