KEGG   PATHWAY: cmax01210
Entry
cmax01210                   Pathway                                
Name
2-Oxocarboxylic acid metabolism - Cucurbita maxima (winter squash)
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
cmax01210  2-Oxocarboxylic acid metabolism
cmax01210

Module
cmax_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:cmax01210]
cmax_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:cmax01210]
cmax_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:cmax01210]
cmax_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:cmax01210]
cmax_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:cmax01210]
Organism
Cucurbita maxima (winter squash) [GN:cmax]
Related
pathway
cmax00020  Citrate cycle (TCA cycle)
cmax00220  Arginine biosynthesis
cmax00250  Alanine, aspartate and glutamate metabolism
cmax00260  Glycine, serine and threonine metabolism
cmax00270  Cysteine and methionine metabolism
cmax00290  Valine, leucine and isoleucine biosynthesis
cmax00300  Lysine biosynthesis
cmax00310  Lysine degradation
cmax00620  Pyruvate metabolism
cmax00640  Propanoate metabolism
cmax00966  Glucosinolate biosynthesis
KO pathway
ko01210   
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