KEGG   PATHWAY: cth02030
Entry
cth02030                    Pathway                                
Name
Bacterial chemotaxis - Acetivibrio thermocellus ATCC 27405
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
Pathway map
cth02030  Bacterial chemotaxis
cth02030

Other DBs
GO: 0006935
Organism
Acetivibrio thermocellus ATCC 27405 [GN:cth]
Gene
Cthe_2819  methyl-accepting chemotaxis sensory transducer [KO:K03406]
Cthe_3156  methyl-accepting chemotaxis sensory transducer [KO:K03406]
Cthe_2663  methyl-accepting chemotaxis sensory transducer [KO:K03406]
Cthe_0039  methyl-accepting chemotaxis sensory transducer [KO:K03406]
Cthe_0298  methyl-accepting chemotaxis sensory transducer [KO:K03406]
Cthe_1498  methyl-accepting chemotaxis sensory transducer [KO:K03406]
Cthe_3030  methyl-accepting chemotaxis sensory transducer with Cache sensor [KO:K03406]
Cthe_3036  methyl-accepting chemotaxis sensory transducer [KO:K03406]
Cthe_0393  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
Cthe_2446  hypothetical protein [KO:K10439]
Cthe_0810  CheA signal transduction histidine kinase [KO:K03407] [EC:2.7.13.3]
Cthe_0490  CheA signal transduction histidine kinase [KO:K03407] [EC:2.7.13.3]
Cthe_2284  CheA signal transduction histidine kinase [KO:K03407] [EC:2.7.13.3]
Cthe_2818  CheA signal transduction histidine kinase [KO:K03407] [EC:2.7.13.3]
Cthe_0878  CheW protein [KO:K03408]
Cthe_0809  CheW protein [KO:K03408]
Cthe_2285  CheW protein [KO:K03408]
Cthe_2817  CheW protein [KO:K03408]
Cthe_0491  CheW protein [KO:K03408]
Cthe_3029  CheW protein [KO:K03408]
Cthe_0080  CheW protein [KO:K03408]
Cthe_0038  CheW protein [KO:K03408]
Cthe_0805  response regulator receiver protein [KO:K03413]
Cthe_0479  response regulator receiver protein [KO:K03413]
Cthe_0811  response regulator receiver protein [KO:K03413]
Cthe_1318  response regulator receiver protein [KO:K03413]
Cthe_0167  response regulator receiver [KO:K03413]
Cthe_1380  response regulator receiver protein [KO:K03413]
Cthe_0492  CheC, inhibitor of MCP methylation [KO:K03410]
Cthe_2308  CheC domain protein [KO:K03409]
Cthe_2406  hypothetical protein [KO:K03409]
Cthe_0126  CheC domain protein [KO:K03409]
Cthe_1176  CheC domain protein [KO:K03409]
Cthe_0489  response regulator receiver modulated CheB methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
Cthe_0807  response regulator receiver modulated CheB methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
Cthe_2821  response regulator receiver modulated CheB methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
Cthe_2281  response regulator receiver modulated CheB methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
Cthe_0493  CheD, stimulates methylation of MCP proteins [KO:K03411] [EC:3.5.1.44]
Cthe_0288  MCP methyltransferase, CheR-type [KO:K00575] [EC:2.1.1.80]
Cthe_0717  MCP methyltransferase, CheR-type [KO:K00575] [EC:2.1.1.80]
Cthe_0808  MCP methyltransferase, CheR-type [KO:K00575] [EC:2.1.1.80]
Cthe_2282  MCP methyltransferase, CheR-type [KO:K00575] [EC:2.1.1.80]
Cthe_2820  MCP methyltransferase, CheR-type [KO:K00575] [EC:2.1.1.80]
Cthe_0466  flagellar motor switch protein FliG [KO:K02410]
Cthe_0477  flagellar motor switch protein FliM [KO:K02416]
Cthe_0478  CheC, inhibitor of MCP methylation / FliN fusion protein [KO:K02417]
Cthe_2425  MotA/TolQ/ExbB proton channel [KO:K02556]
Cthe_2426  OmpA/MotB domain protein [KO:K02557]
Compound
C00049  L-Aspartate
C00107  Dipeptide
C00121  D-Ribose
C00124  D-Galactose
C00208  Maltose
C00716  Serine
Reference
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
DOI:10.1074/jbc.M201334200
Reference
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
DOI:10.1046/j.1365-2958.2001.02581.x
Reference
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
DOI:10.1074/jbc.M306180200
Reference
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
DOI:10.1074/jbc.M311497200
Reference
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
DOI:10.1093/pcp/pce007
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
DOI:10.1128/JB.175.18.5934-5944.1993
Reference
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
DOI:10.1128/MMBR.68.2.301-319.2004
Reference
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
DOI:10.1016/j.tim.2008.07.003
Reference
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
DOI:10.1111/j.1365-2958.2008.06482.x
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Related
pathway
cth02040  Flagellar assembly
KO pathway
ko02030   
LinkDB

DBGET integrated database retrieval system