KEGG   PATHWAY: dmu01210
Entry
dmu01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Desulfurococcus mucosus
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
dmu01210  2-Oxocarboxylic acid metabolism
dmu01210

Module
dmu_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:dmu01210]
Organism
Desulfurococcus mucosus [GN:dmu]
Related
pathway
dmu00020  Citrate cycle (TCA cycle)
dmu00220  Arginine biosynthesis
dmu00250  Alanine, aspartate and glutamate metabolism
dmu00260  Glycine, serine and threonine metabolism
dmu00270  Cysteine and methionine metabolism
dmu00300  Lysine biosynthesis
dmu00310  Lysine degradation
dmu00620  Pyruvate metabolism
dmu00640  Propanoate metabolism
dmu00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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