KEGG   PATHWAY: dor01210
Entry
dor01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Desulfosporosinus orientis
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
dor01210  2-Oxocarboxylic acid metabolism
dor01210

Module
dor_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:dor01210]
dor_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:dor01210]
dor_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:dor01210]
dor_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:dor01210]
Organism
Desulfosporosinus orientis [GN:dor]
Related
pathway
dor00020  Citrate cycle (TCA cycle)
dor00220  Arginine biosynthesis
dor00250  Alanine, aspartate and glutamate metabolism
dor00260  Glycine, serine and threonine metabolism
dor00270  Cysteine and methionine metabolism
dor00290  Valine, leucine and isoleucine biosynthesis
dor00300  Lysine biosynthesis
dor00310  Lysine degradation
dor00620  Pyruvate metabolism
dor00640  Propanoate metabolism
dor00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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