KEGG   PATHWAY: eoc01230
Entry
eoc01230                    Pathway                                
Name
Biosynthesis of amino acids - Escherichia coli O7:K1 CE10
Description
This map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module for conversion of three-carbon compounds from glyceraldehyde-3P to pyruvate [MD:M00002], together with the pathways around serine and glycine. This KEGG module is the most conserved one in the KEGG MODULE database and is found in almost all the completely sequenced genomes. The extensions are the pathways containing the reaction modules RM001, RM033, RM032, and RM002 for biosynthesis of branched-chain amino acids (left) and basic amino acids (bottom), and the pathways for biosynthesis of histidine and aromatic amino acids (top right). It is interesting to note that the so-called essential amino acids that cannot be synthesized in human and other organisms generally appear in these extensions. Furthermore, the bottom extension of basic amino acids appears to be most divergent containing multiple pathways for lysine biosynthesis and multiple gene sets for arginine biosynthesis.
Class
Pathway map
eoc01230  Biosynthesis of amino acids
eoc01230

Module
eoc_M00002  Glycolysis, core module involving three-carbon compounds [PATH:eoc01230]
eoc_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:eoc01230]
eoc_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:eoc01230]
eoc_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:eoc01230]
eoc_M00015  Proline biosynthesis, glutamate => proline [PATH:eoc01230]
eoc_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:eoc01230]
eoc_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:eoc01230]
eoc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:eoc01230]
eoc_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:eoc01230]
eoc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:eoc01230]
eoc_M00021  Cysteine biosynthesis, serine => cysteine [PATH:eoc01230]
eoc_M00022  Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:eoc01230]
eoc_M00023  Tryptophan biosynthesis, chorismate => tryptophan [PATH:eoc01230]
eoc_M00024  Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:eoc01230]
eoc_M00025  Tyrosine biosynthesis, chorismate => HPP => tyrosine [PATH:eoc01230]
eoc_M00026  Histidine biosynthesis, PRPP => histidine [PATH:eoc01230]
eoc_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:eoc01230]
eoc_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:eoc01230]
eoc_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:eoc01230]
eoc_M00844  Arginine biosynthesis, ornithine => arginine [PATH:eoc01230]
Organism
Escherichia coli O7:K1 CE10 [GN:eoc]
KO pathway
ko01230   
LinkDB

DBGET integrated database retrieval system