KEGG   PATHWAY: hsyr00908
Entry
hsyr00908                   Pathway                                
Name
Zeatin biosynthesis - Hibiscus syriacus (Rose-of-Sharon)
Description
Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
hsyr00908  Zeatin biosynthesis
hsyr00908

Other DBs
GO: 0009691
Organism
Hibiscus syriacus (Rose-of-Sharon) [GN:hsyr]
Gene
120113445  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120130405  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120115829  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120133150  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120134196  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120135147  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120151114  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120184734  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120137260  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120169629  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120137749  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120188170  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120188888  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120141226  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120142717  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120143279  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120209189  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
120196744  cytokinin hydroxylase-like [KO:K10717]
120139135  cytokinin hydroxylase-like isoform X1 [KO:K10717]
120190119  cytokinin hydroxylase-like [KO:K10717]
120212091  cytokinin hydroxylase-like isoform X1 [KO:K10717]
120113595  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
120180068  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
120149217  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
120185841  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
120153705  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
120169340  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
120187602  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
120138530  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
120138722  cytokinin dehydrogenase 6-like [KO:K00279] [EC:1.5.99.12]
120192282  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
120192322  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
120194660  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
120195285  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
120211850  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
120117809  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
120131990  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
120147828  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
120162161  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
120164690  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
120169288  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
120197884  UDP-glycosyltransferase 73C5-like [KO:K13496] [EC:2.4.1.-]
120214506  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
120214507  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
120214509  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
120183872  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
120154012  UDP-glycosyltransferase 73C4-like [KO:K13496] [EC:2.4.1.-]
120121432  UDP-glycosyltransferase 73C1-like [KO:K13496] [EC:2.4.1.-]
120158074  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
120143098  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
120143140  UDP-glycosyltransferase 73C5-like [KO:K13496] [EC:2.4.1.-]
120143141  UDP-glycosyltransferase 73C5-like [KO:K13496] [EC:2.4.1.-]
120211703  UDP-glycosyltransferase 73C1-like [KO:K13496] [EC:2.4.1.-]
120211704  UDP-glycosyltransferase 73C5-like [KO:K13496] [EC:2.4.1.-]
120143913  LOW QUALITY PROTEIN: tRNA dimethylallyltransferase 9 [KO:K00791] [EC:2.5.1.75]
120144191  tRNA dimethylallyltransferase 2 [KO:K00791] [EC:2.5.1.75]
120216469  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
120216812  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
120155523  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
120155627  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00019  S-Adenosyl-L-methionine
C00020  AMP
C00029  UDP-glucose
C00033  Acetate
C00147  Adenine
C00170  5'-Methylthioadenosine
C00190  UDP-D-xylose
C00235  Dimethylallyl diphosphate
C00371  Zeatin
C00979  O-Acetyl-L-serine
C01513  Lupinate
C01804  Discadenine
C02029  Dihydrozeatin
C03300  O-beta-D-Xylosylzeatin
C03423  O-beta-D-Glucosylzeatin
C04083  N6-(Delta2-Isopentenyl)-adenine
C04432  tRNA containing 6-isopentenyladenosine
C04713  N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
C07330  3-Methyl-2-butenal
C15545  cis-Zeatin
C15546  O-beta-D-Glucopyranosyl-cis-zeatin
C16424  Isopentenyladenosine-5'-triphosphate
C16426  Isopentenyladenosine-5'-diphosphate
C16427  Isopentenyl adenosine
C16428  trans-Zeatin riboside triphosphate
C16429  trans-Zeatin riboside diphosphate
C16430  trans-Zeatin riboside monophosphate
C16431  trans-Zeatin riboside
C16441  cis-Zeatin riboside monophosphate
C16443  trans-Zeatin-7-beta-D-glucoside
C16445  Dihydrozeatin riboside monophosphate
C16447  Dihydrozeatin riboside
C16448  Dihydrozeatin-O-glucoside
C16449  cis-Zeatin riboside
C16467  cis-Prenyl-tRNA
C17324  tRNA adenine
Reference
  Authors
Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  Title
Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  Journal
J Biol Chem 279:14049-54 (2004)
DOI:10.1074/jbc.M314195200
Reference
  Authors
Takei K, Sakakibara H, Sugiyama T.
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J Biol Chem 276:26405-10 (2001)
DOI:10.1074/jbc.M102130200
Reference
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant Cell Physiol 42:677-85 (2001)
DOI:10.1093/pcp/pce112
Reference
  Authors
Takei K, Yamaya T, Sakakibara H.
  Title
Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  Journal
J Biol Chem 279:41866-72 (2004)
DOI:10.1074/jbc.M406337200
Reference
  Authors
Hou B, Lim EK, Higgins GS, Bowles DJ.
  Title
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  Journal
J Biol Chem 279:47822-32 (2004)
DOI:10.1074/jbc.M409569200
Reference
PMID:9874810
  Authors
Martin RC, Mok MC, Mok DW
  Title
Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  Journal
Proc Natl Acad Sci U S A 96:284-9 (1999)
DOI:10.1073/pnas.96.1.284
Reference
  Authors
Martin RC, Mok MC, Mok DW
  Title
A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  Journal
Plant Physiol 120:553-8 (1999)
DOI:10.1104/pp.120.2.553
Reference
  Authors
Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  Title
O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  Journal
Plant Physiol 131:1374-80 (2003)
DOI:10.1104/pp.017210
Reference
  Authors
Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  Title
Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  Journal
Plant Cell 15:2532-50 (2003)
DOI:10.1105/tpc.014928
Reference
  Authors
Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  Title
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 103:16598-603 (2006)
DOI:10.1073/pnas.0603522103
Related
pathway
hsyr00900  Terpenoid backbone biosynthesis
KO pathway
ko00908   
LinkDB

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