KEGG   PATHWAY: htl01210
Entry
htl01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Hydrogenophilus thermoluteolus
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
htl01210  2-Oxocarboxylic acid metabolism
htl01210

Module
htl_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:htl01210]
htl_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:htl01210]
htl_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:htl01210]
htl_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:htl01210]
htl_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:htl01210]
htl_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:htl01210]
Organism
Hydrogenophilus thermoluteolus [GN:htl]
Related
pathway
htl00020  Citrate cycle (TCA cycle)
htl00220  Arginine biosynthesis
htl00250  Alanine, aspartate and glutamate metabolism
htl00260  Glycine, serine and threonine metabolism
htl00270  Cysteine and methionine metabolism
htl00290  Valine, leucine and isoleucine biosynthesis
htl00300  Lysine biosynthesis
htl00310  Lysine degradation
htl00620  Pyruvate metabolism
htl00640  Propanoate metabolism
htl00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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