KEGG   PATHWAY: ibu01210
Entry
ibu01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Intestinimonas butyriciproducens
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
ibu01210  2-Oxocarboxylic acid metabolism
ibu01210

Module
ibu_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:ibu01210]
ibu_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ibu01210]
ibu_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:ibu01210]
ibu_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:ibu01210]
ibu_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ibu01210]
Organism
Intestinimonas butyriciproducens [GN:ibu]
Related
pathway
ibu00020  Citrate cycle (TCA cycle)
ibu00220  Arginine biosynthesis
ibu00250  Alanine, aspartate and glutamate metabolism
ibu00260  Glycine, serine and threonine metabolism
ibu00270  Cysteine and methionine metabolism
ibu00290  Valine, leucine and isoleucine biosynthesis
ibu00300  Lysine biosynthesis
ibu00310  Lysine degradation
ibu00620  Pyruvate metabolism
ibu00640  Propanoate metabolism
ibu00680  Methane metabolism
KO pathway
ko01210   
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