KEGG   PATHWAY: mgad01210
Entry
mgad01210                   Pathway                                
Name
2-Oxocarboxylic acid metabolism - Mycolicibacterium gadium
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
mgad01210  2-Oxocarboxylic acid metabolism
mgad01210

Module
mgad_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:mgad01210]
mgad_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:mgad01210]
mgad_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:mgad01210]
mgad_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:mgad01210]
mgad_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:mgad01210]
mgad_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mgad01210]
mgad_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:mgad01210]
Organism
Mycolicibacterium gadium [GN:mgad]
Related
pathway
mgad00020  Citrate cycle (TCA cycle)
mgad00220  Arginine biosynthesis
mgad00250  Alanine, aspartate and glutamate metabolism
mgad00260  Glycine, serine and threonine metabolism
mgad00270  Cysteine and methionine metabolism
mgad00290  Valine, leucine and isoleucine biosynthesis
mgad00300  Lysine biosynthesis
mgad00310  Lysine degradation
mgad00620  Pyruvate metabolism
mgad00640  Propanoate metabolism
mgad00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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