KEGG   PATHWAY: mgy02030
Entry
mgy02030                    Pathway                                
Name
Bacterial chemotaxis - Magnetospirillum gryphiswaldense MSR-1 v2
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
Pathway map
mgy02030  Bacterial chemotaxis
mgy02030

Other DBs
GO: 0006935
Organism
Magnetospirillum gryphiswaldense MSR-1 v2 [GN:mgy]
Gene
MGMSRv2__2036  putative chemotaxis methyl-accepting receptor [KO:K03406]
MGMSRv2__2081  putative Chemotaxis methyl-accepting receptor, signalling [KO:K03406]
MGMSRv2__3585  putative chemotaxis methyl-accepting receptor [KO:K03406]
MGMSRv2__0734  putative chemoreceptor [KO:K03406]
MGMSRv2__0740  Putative Methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__2842  putative Chemoreceptor mcpA [KO:K03406]
MGMSRv2__0794  conserved protein of unknown function [KO:K03406]
MGMSRv2__3705  Methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__3729  putative Methyl-accepting chemotaxis sensory transducer [KO:K03406]
MGMSRv2__2176  Methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__2934  putative Methyl-accepting chemotaxis sensory transducer [KO:K03406]
MGMSRv2__0152  putative Histidine kinase, HAMP region:Bacterial chemotaxis sensory transducer [KO:K03406]
MGMSRv2__0874  putative Methyl-accepting chemotaxis sensory transducer [KO:K03406]
MGMSRv2__2284  Putative Methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__0237  putative chemotaxis methyl-accepting receptor, signalling [KO:K03406]
MGMSRv2__0965  putative Methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__0977  Histidine kinase, HAMP region:Bacterial chemotaxis sensory transducer [KO:K03406]
MGMSRv2__0983  putative methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__1691  Methyl-accepting chemotaxis sensory transducer [KO:K03406]
MGMSRv2__3090  Histidine kinase, HAMP region:Bacterial chemotaxis sensory transducer [KO:K03406]
MGMSRv2__0391  putative chemotaxis methyl-accepting receptor [KO:K03406]
MGMSRv2__1867  Putative methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__1868  putative methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__1877  Methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__1353  conserved protein of unknown function, containing chemotaxis methyl-accepting receptor, signalling [KO:K03406]
MGMSRv2__2009  putative chemotaxis methyl-accepting receptor, signalling [KO:K03406]
MGMSRv2__2724  mcp4; Methyl-accepting chemotaxis sensory transducer [KO:K03406]
MGMSRv2__2732  mcp; Chemotaxis sensory transducer [KO:K03406]
MGMSRv2__2733  mcp4; Methyl-accepting chemotaxis protein 4 [KO:K03406]
MGMSRv2__4255  putative Methyl-accepting chemotaxis protein (modular protein) [KO:K03406]
MGMSRv2__3965  putative Methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__4038  mcp; Methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__4077  mcp; Methyl-accepting chemotaxis protein [KO:K03406]
MGMSRv2__4081  putative chemoreceptor mcpA [KO:K03406]
MGMSRv2__1376  Methyl-accepting chemotaxis protein [KO:K03776]
MGMSRv2__3813  aer; fused signal transducer for aerotaxis sensory component; methyl accepting chemotaxis component [KO:K03776]
MGMSRv2__1275  putative D-ribose-binding periplasmic protein [KO:K10439]
MGMSRv2__0985  cheA; Chemotaxis protein cheA [KO:K03407] [EC:2.7.13.3]
MGMSRv2__2918  cheA; Chemotaxis protein cheA [KO:K03407] [EC:2.7.13.3]
MGMSRv2__1359  putative gliding motility regulatory protein [KO:K03407] [EC:2.7.13.3]
MGMSRv2__3726  putative gliding motility regulatory protein [KO:K03407] [EC:2.7.13.3]
MGMSRv2__0984  cheW; Chemotaxis protein cheW [KO:K03408]
MGMSRv2__1361  conserved protein of unknown function, containing CheW-like protein [KO:K03408]
MGMSRv2__1363  conserved protein of unknown function, containing CheW-like protein [KO:K03408]
MGMSRv2__3723  putative chemotaxis protein CheW [KO:K03408]
MGMSRv2__2919  cheW; Transducer coupling protein [KO:K03408]
MGMSRv2__2527  cheY; Chemotaxis protein CheY [KO:K03413]
MGMSRv2__0950  cheY; regulator of chemotaxis and motility [KO:K03413]
MGMSRv2__2051  Putative response regulator receiver (CheY-like protein) [KO:K03413]
MGMSRv2__2707  conserved protein of unknown function, containing signal transduction response regulator, receiver domain [KO:K03413]
MGMSRv2__0986  cheY; Chemotaxis protein cheY [KO:K03413]
MGMSRv2__0018  putative CheY-like receiver [KO:K03413]
MGMSRv2__0724  putative probable chemotaxis protein CheY [KO:K03413]
MGMSRv2__3647  cheY; Chemotaxis protein CheY [KO:K03413]
MGMSRv2__3710  cheY; chemotaxis regulator transmitting signal to flagellar motor component [KO:K03413]
MGMSRv2__2920  cheY; regulator of chemotaxis and motility [KO:K03413]
MGMSRv2__3086  cheY; Chemotaxis protein CheY [KO:K03413]
MGMSRv2__0456  putative signal transduction response regulator(Chemotaxis protein CheY) [KO:K03413]
MGMSRv2__0457  cheY; Signal transduction response regulator(Chemotaxis protein CheY) [KO:K03413]
MGMSRv2__2070  putative CheC-like protein [KO:K03410]
MGMSRv2__3709  putative Protein phosphatase CheZ [KO:K03414]
MGMSRv2__2935  conserved protein of unknown function [KO:K03414]
MGMSRv2__2487  conserved protein of unknown function [KO:K03414]
MGMSRv2__2698  cheZ; Protein phosphatase CheZ [KO:K03414]
MGMSRv2__0980  cheB; Chemotaxis Response Regulator protein CheB-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
MGMSRv2__1358  cheB4; Chemotaxis response regulator protein-glutamate methylesterase 4 [KO:K03412] [EC:3.1.1.61 3.5.1.44]
MGMSRv2__3728  cheB3; Chemotaxis response regulator protein-glutamate methylesterase 3 [KO:K03412] [EC:3.1.1.61 3.5.1.44]
MGMSRv2__2921  cheB; Chemotaxis response regulator protein-glutamate methylesterase 1 [KO:K03412] [EC:3.1.1.61 3.5.1.44]
MGMSRv2__1656  MCP methyltransferase/methylesterase, CheR/CheB with PAS/PAC sensor [KO:K13924] [EC:2.1.1.80 3.1.1.61]
MGMSRv2__1667  conserved protein of unknown function [KO:K13924] [EC:2.1.1.80 3.1.1.61]
MGMSRv2__3079  gmr; modulator of Rnase II stability [KO:K13924] [EC:2.1.1.80 3.1.1.61]
MGMSRv2__0732  Cyanobacterial phytochrome A [KO:K13924] [EC:2.1.1.80 3.1.1.61]
MGMSRv2__0981  cheD; Chemotaxis protein cheD [KO:K03411] [EC:3.5.1.44]
MGMSRv2__0982  cheR; Chemotaxis protein methyltransferase [KO:K00575] [EC:2.1.1.80]
MGMSRv2__1362  Chemotaxis protein methyltransferase [KO:K00575] [EC:2.1.1.80]
MGMSRv2__3727  putative Protein methyltransferase frzF [KO:K00575] [EC:2.1.1.80]
MGMSRv2__2922  cheR; Chemotaxis protein methyltransferase [KO:K00575] [EC:2.1.1.80]
MGMSRv2__3630  fliG; Flagellar motor switch protein fliG [KO:K02410]
MGMSRv2__3713  fliM; Flagellar motor switch protein FliM [KO:K02416]
MGMSRv2__2064  putative flagellar motor switch FliN/Type III secretion HrcQb [KO:K02417]
MGMSRv2__3628  fliN; Flagellar motor switch protein FliN [KO:K02417]
MGMSRv2__1013  putative flagellar motor component [KO:K02556]
MGMSRv2__1101  putative Motility protein A [KO:K02556]
MGMSRv2__0245  Putative outer membrane protein, OmpA/MotB, C-terminal [KO:K02557]
MGMSRv2__1012  putative flagellar motor apparatus component [KO:K02557]
MGMSRv2__1100  putative Flagellar motor protein [KO:K02557]
Compound
C00049  L-Aspartate
C00107  Dipeptide
C00121  D-Ribose
C00124  D-Galactose
C00208  Maltose
C00716  Serine
Reference
PMID:12011078
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
DOI:10.1074/jbc.M201334200
Reference
PMID:11722727
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
DOI:10.1046/j.1365-2958.2001.02581.x
Reference
PMID:12920116
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
DOI:10.1074/jbc.M306180200
Reference
PMID:14749334
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
DOI:10.1074/jbc.M311497200
Reference
PMID:11158445
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
DOI:10.1093/pcp/pce007
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
DOI:10.1128/JB.175.18.5934-5944.1993
Reference
PMID:15187186
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
DOI:10.1128/MMBR.68.2.301-319.2004
Reference
PMID:18774298
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
DOI:10.1016/j.tim.2008.07.003
Reference
PMID:18990184
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
DOI:10.1111/j.1365-2958.2008.06482.x
Reference
PMID:19203648
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Related
pathway
mgy02040  Flagellar assembly
KO pathway
ko02030   
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