KEGG   PATHWAY: mmea04136
Entry
mmea04136                   Pathway                                
Name
Autophagy - other - Malurus melanocephalus (red-backed fairy wren)
Description
Autophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either in a housekeeping capacity or during stress and senescence. The process of autophagy could be divided into several stages: induction, vesicle nucleation, elongation and closure, and fusion and digestion. Most essential autophagic machineries are conserved throughout eukaryotes (see map04140 for animals and map04138 for fungi). This map is for other eukaryotes including plants and protists, where autophagy related genes (ATGs) play similar roles in the life cycle. However, autophagy has been relatively less studied in lower eukaryotes.
Class
Cellular Processes; Transport and catabolism
Pathway map
mmea04136  Autophagy - other
mmea04136

Other DBs
GO: 0006914
Organism
Malurus melanocephalus (red-backed fairy wren) [GN:mmea]
Gene
130586007  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR-like [KO:K07204]
130586127  regulatory-associated protein of mTOR-like [KO:K07204]
130583073  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
130576496  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
130576935  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
130572945  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
130586318  ATG101; autophagy-related protein 101 [KO:K19730]
130586374  IGBP1; immunoglobulin-binding protein 1 [KO:K17606]
130583134  immunoglobulin-binding protein 1-like [KO:K17606]
130585859  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
130576568  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
130574392  ATG9A; autophagy-related protein 9A [KO:K17907]
130574591  ATG9B; autophagy-related protein 9B [KO:K17907]
130576908  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
130575717  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
130584178  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
130581420  BECN1; beclin-1 [KO:K08334]
130584511  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
130577404  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
130577197  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
130589021  autophagy protein 5 [KO:K08339]
130583186  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
130586010  ATG7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
130586034  ATG10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
130572479  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
130576136  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
130587889  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
130583607  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
130576036  ATG4C; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
130582332  ATG4B; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
130573323  ATG4A; cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Duszenko M, Ginger ML, Brennand A, Gualdron-Lopez M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, de Castro SL, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romano PS, Stoka V, Turk B, Michels PA
  Title
Autophagy in protists.
  Journal
Autophagy 7:127-58 (2011)
DOI:10.4161/auto.7.2.13310
Reference
  Authors
Avin-Wittenberg T, Honig A, Galili G
  Title
Variations on a theme: plant autophagy in comparison to yeast and mammals.
  Journal
Protoplasma 249:285-99 (2012)
DOI:10.1007/s00709-011-0296-z
Reference
  Authors
Liu Y, Bassham DC
  Title
Autophagy: pathways for self-eating in plant cells.
  Journal
Annu Rev Plant Biol 63:215-37 (2012)
DOI:10.1146/annurev-arplant-042811-105441
Reference
  Authors
Yoshimoto K
  Title
Beginning to understand autophagy, an intracellular self-degradation system in plants.
  Journal
Plant Cell Physiol 53:1355-65 (2012)
DOI:10.1093/pcp/pcs099
Reference
  Authors
Li F, Chung T, Vierstra RD
  Title
AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis.
  Journal
Plant Cell 26:788-807 (2014)
DOI:10.1105/tpc.113.120014
Reference
  Authors
Michaeli S, Galili G, Genschik P, Fernie AR, Avin-Wittenberg T
  Title
Autophagy in Plants--What's New on the Menu?
  Journal
Trends Plant Sci 21:134-44 (2016)
DOI:10.1016/j.tplants.2015.10.008
Reference
  Authors
Yang X, Bassham DC
  Title
New Insight into the Mechanism and Function of Autophagy in Plant Cells.
  Journal
Int Rev Cell Mol Biol 320:1-40 (2015)
DOI:10.1016/bs.ircmb.2015.07.005
KO pathway
ko04136   
LinkDB

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