KEGG   PATHWAY: mmq01210
Entry
mmq01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Methanococcus maripaludis C5
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
mmq01210  2-Oxocarboxylic acid metabolism
mmq01210

Module
mmq_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:mmq01210]
mmq_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:mmq01210]
mmq_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mmq01210]
mmq_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:mmq01210]
mmq_M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:mmq01210]
mmq_M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate [PATH:mmq01210]
Organism
Methanococcus maripaludis C5 [GN:mmq]
Related
pathway
mmq00020  Citrate cycle (TCA cycle)
mmq00220  Arginine biosynthesis
mmq00250  Alanine, aspartate and glutamate metabolism
mmq00260  Glycine, serine and threonine metabolism
mmq00270  Cysteine and methionine metabolism
mmq00290  Valine, leucine and isoleucine biosynthesis
mmq00300  Lysine biosynthesis
mmq00310  Lysine degradation
mmq00620  Pyruvate metabolism
mmq00640  Propanoate metabolism
mmq00680  Methane metabolism
KO pathway
ko01210   
LinkDB

DBGET integrated database retrieval system