KEGG   PATHWAY: nai03460
Entry
nai03460                    Pathway                                
Name
Fanconi anemia pathway - Necator americanus (New World hookworm)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
nai03460  Fanconi anemia pathway
nai03460

Other DBs
GO: 0043240
Organism
Necator americanus (New World hookworm) [GN:nai]
Gene
NECAME_04636  hypothetical protein [KO:K15360]
NECAME_16465  hypothetical protein [KO:K11137]
NECAME_08781  hypothetical protein [KO:K04482]
NECAME_14972  VRR-NUC domain protein [KO:K15363] [EC:3.1.21.- 3.1.4.1]
NECAME_02884  DNA mismatch repair protein [KO:K08734]
NECAME_01401  DNA mismatch repair protein [KO:K10858]
NECAME_04048  DNA polymerase family B [KO:K02350] [EC:2.7.7.7]
NECAME_08514  ImpB/MucB/SamB family protein [KO:K03509] [EC:2.7.7.7]
NECAME_08515  ImpB/MucB/SamB family protein [KO:K03509] [EC:2.7.7.7]
NECAME_08039  hypothetical protein [KO:K10990]
NECAME_06189  DNA topoisomerase [KO:K03165] [EC:5.6.2.1]
NECAME_02538  replication factor-A domain protein [KO:K07466]
NECAME_07577  hypothetical protein [KO:K10739]
NECAME_01737  ERCC4 domain protein [KO:K08991] [EC:3.1.22.-]
NECAME_00989  DNA repair protein rad10 [KO:K10849]
NECAME_04275  hypothetical protein [KO:K15078] [EC:3.6.1.-]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
nai03430  Mismatch repair
nai03440  Homologous recombination
KO pathway
ko03460   
LinkDB

DBGET integrated database retrieval system