KEGG   PATHWAY: olo01210
Entry
olo01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Olsenella sp. oral taxon 807
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
olo01210  2-Oxocarboxylic acid metabolism
olo01210

Module
olo_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:olo01210]
olo_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:olo01210]
olo_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:olo01210]
olo_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:olo01210]
olo_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:olo01210]
Organism
Olsenella sp. oral taxon 807 [GN:olo]
Related
pathway
olo00020  Citrate cycle (TCA cycle)
olo00220  Arginine biosynthesis
olo00250  Alanine, aspartate and glutamate metabolism
olo00260  Glycine, serine and threonine metabolism
olo00270  Cysteine and methionine metabolism
olo00290  Valine, leucine and isoleucine biosynthesis
olo00300  Lysine biosynthesis
olo00310  Lysine degradation
olo00620  Pyruvate metabolism
olo00640  Propanoate metabolism
olo00680  Methane metabolism
KO pathway
ko01210   
LinkDB

DBGET integrated database retrieval system