KEGG   PATHWAY: rfl01210
Entry
rfl01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Roseomonas fluvialis
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
rfl01210  2-Oxocarboxylic acid metabolism
rfl01210

Module
rfl_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:rfl01210]
rfl_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:rfl01210]
rfl_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:rfl01210]
rfl_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:rfl01210]
rfl_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:rfl01210]
rfl_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:rfl01210]
Organism
Roseomonas fluvialis [GN:rfl]
Related
pathway
rfl00020  Citrate cycle (TCA cycle)
rfl00220  Arginine biosynthesis
rfl00250  Alanine, aspartate and glutamate metabolism
rfl00260  Glycine, serine and threonine metabolism
rfl00270  Cysteine and methionine metabolism
rfl00290  Valine, leucine and isoleucine biosynthesis
rfl00300  Lysine biosynthesis
rfl00310  Lysine degradation
rfl00620  Pyruvate metabolism
rfl00640  Propanoate metabolism
rfl00680  Methane metabolism
KO pathway
ko01210   
LinkDB

DBGET integrated database retrieval system