KEGG   PATHWAY: smel02030
Entry
smel02030                   Pathway                                
Name
Bacterial chemotaxis - Sinorhizobium meliloti 2011
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
Pathway map
smel02030  Bacterial chemotaxis
smel02030

Other DBs
GO: 0006935
Organism
Sinorhizobium meliloti 2011 [GN:smel]
Gene
SM2011_c03004  icpA; IcpA/McpE internal chemotaxis protein [KO:K03406]
SM2011_c00765  mcpZ; putative methyl-accepting chemotaxis protein [KO:K03406]
SM2011_c01104  mcpX; putative chemoreceptor (methyl-accepting chemotaxis) transmembrane protein [KO:K03406]
SM2011_c01719  mcpT; putative chemoreceptor (methyl-accepting chemotaxis) transmembrane protein [KO:K03406]
SM2011_c00975  mcpU; putative chemoreceptor (methyl-accepting chemotaxis) transmembrane protein [KO:K03406]
SM2011_a1556  mcpS; Methyl-accepting chemotaxis protein [KO:K03406]
SM2011_c04227  mcpV; putative chemoreceptor (methyl-accepting chemotaxis) transmembrane protein [KO:K03406]
SM2011_c01469  mcpW; putative methyl accepting chemotaxis transmembrane protein [KO:K03406]
SM2011_c03087  mcpY; Chemoreceptor (methyl-accepting chemotaxis protein) [KO:K03406]
SM2011_b20018  putative sugar ABC transporter,ATP-binding protein [KO:K10439]
SM2011_a0203  ABC transporter,periplasmic solute-binding protein,likely transports galactose and,to a lesser extent,L-arabinose,glucose,D-arabinose,L-fucose and D-fucose [KO:K10439]
SM2011_a1427  ABC transporter,periplasmic solute-binding protein,involved in transport of sugar phosphates (glucose-6-phosphate and glycerol-3-phosphate) [KO:K10439]
SM2011_b20931  Putative galactoside ABC transporter,periplasmic solute-binding protein [KO:K10439]
SM2011_c03813  Putative periplasmic binding ABC transporter [KO:K10439]
SM2011_c02033  Sugar-binding periplasmic protein precursor [KO:K10439]
SM2011_c02021  Putative organic acid ABC transporter,periplasmic solute-binding component [KO:K10439]
SM2011_a2000  ABC transporter,periplasmic solute-binding protein [KO:K10439]
SM2011_b21421  ABC transporter,periplasmic solute-binding protein [KO:K10439]
SM2011_b20856  Putative deoxyribose ABC transporter,periplasmic solute-binding protein [KO:K10439]
SM2011_b20720  Putative sugar uptake ABC transporter periplasmic solute-binding protein precursor [KO:K10439]
SM2011_c02774  Putative D-fucose,pyruvic acid or L-fucose ABC transporter,periplasmic substrate-binding component [KO:K10439]
SM2011_b20671  Putative sugar uptake ABC transporter periplasmic solute-binding protein precursor [KO:K10439]
SM2011_b20504  Putative ABC transporter periplasmic sugar-binding protein [KO:K10439]
SM2011_b21377  Putative polyols and C6 monosaccharide ABC transporter,periplasmic solute-binding protein [KO:K10439]
SM2011_a0273  ABC transporter,periplasmic solute-binding protein [KO:K10439]
SM2011_c02338  Sugar-binding periplasmic protein precursor [KO:K10439]
SM2011_c00786  dppA1; Oligopeptide ABC transporter,periplasmic solute-binding component [KO:K12368]
SM2011_c03007  cheA; Chemotaxis protein (sensory transduction histidine kinase) [KO:K03407] [EC:2.7.13.3]
SM2011_a1558  Sensor histidine kinase [KO:K03407] [EC:2.7.13.3]
SM2011_c03008  cheW1; Chemotaxis protein [KO:K03408]
SM2011_c01468  cheW2; putative chemotaxis protein [KO:K03408]
SM2011_c03090  cheW3; Putative chemotaxis protein [KO:K03408]
SM2011_a1554  Putative chemotaxis protein [KO:K03408]
SM2011_c03006  cheY1; Chemotaxis regulator protein [KO:K03413]
SM2011_c03011  cheY2; Response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain protein [KO:K03413]
SM2011_c00653  Putative 2-component receiver domain protein [KO:K03413]
SM2011_c03005  hypothetical protein [KO:K03409]
SM2011_c03010  cheB1; Chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
SM2011_b20514  Protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
SM2011_a1561  cheB2; Chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
SM2011_b20515  Putative methyltransferase [KO:K13924] [EC:2.1.1.80 3.1.1.61]
SM2011_c03012  cheD; putative chemotaxis protein [KO:K03411] [EC:3.5.1.44]
SM2011_c03009  cheR; Chemotaxis protein methyltransferase [KO:K00575] [EC:2.1.1.80]
SM2011_a1552  MCP methyltransferase,CheR-type [KO:K00575] [EC:2.1.1.80]
SM2011_c03019  fliG; Flagellar motor switch protein [KO:K02410]
SM2011_c03021  fliM; Flagellar motor switch transmembrane protein [KO:K02416]
SM2011_c03020  fliN; Flagellar motor switch protein [KO:K02417]
SM2011_c03022  motA; Chemotaxis (motility protein A) transmembrane [KO:K02556]
SM2011_c03042  motB; Chemotaxis (motility protein B) transmembrane [KO:K02557]
SM2011_c03992  Hypothetical protein signal peptide [KO:K02557]
Compound
C00049  L-Aspartate
C00107  Dipeptide
C00121  D-Ribose
C00124  D-Galactose
C00208  Maltose
C00716  Serine
Reference
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
DOI:10.1074/jbc.M201334200
Reference
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
DOI:10.1046/j.1365-2958.2001.02581.x
Reference
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
DOI:10.1074/jbc.M306180200
Reference
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
DOI:10.1074/jbc.M311497200
Reference
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
DOI:10.1093/pcp/pce007
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
DOI:10.1128/JB.175.18.5934-5944.1993
Reference
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
DOI:10.1128/MMBR.68.2.301-319.2004
Reference
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
DOI:10.1016/j.tim.2008.07.003
Reference
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
DOI:10.1111/j.1365-2958.2008.06482.x
Reference
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Related
pathway
smel02040  Flagellar assembly
KO pathway
ko02030   
LinkDB

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