KEGG   PATHWAY: ssub01230
Entry
ssub01230                   Pathway                                
Name
Biosynthesis of amino acids - Streptomyces subrutilus
Description
This map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module for conversion of three-carbon compounds from glyceraldehyde-3P to pyruvate [MD:M00002], together with the pathways around serine and glycine. This KEGG module is the most conserved one in the KEGG MODULE database and is found in almost all the completely sequenced genomes. The extensions are the pathways containing the reaction modules RM001, RM033, RM032, and RM002 for biosynthesis of branched-chain amino acids (left) and basic amino acids (bottom), and the pathways for biosynthesis of histidine and aromatic amino acids (top right). It is interesting to note that the so-called essential amino acids that cannot be synthesized in human and other organisms generally appear in these extensions. Furthermore, the bottom extension of basic amino acids appears to be most divergent containing multiple pathways for lysine biosynthesis and multiple gene sets for arginine biosynthesis.
Class
Pathway map
ssub01230  Biosynthesis of amino acids
ssub01230

Module
ssub_M00002  Glycolysis, core module involving three-carbon compounds [PATH:ssub01230]
ssub_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ssub01230]
ssub_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:ssub01230]
ssub_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:ssub01230]
ssub_M00015  Proline biosynthesis, glutamate => proline [PATH:ssub01230]
ssub_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:ssub01230]
ssub_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ssub01230]
ssub_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ssub01230]
ssub_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ssub01230]
ssub_M00023  Tryptophan biosynthesis, chorismate => tryptophan [PATH:ssub01230]
ssub_M00026  Histidine biosynthesis, PRPP => histidine [PATH:ssub01230]
ssub_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:ssub01230]
ssub_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:ssub01230]
ssub_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ssub01230]
ssub_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ssub01230]
ssub_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ssub01230]
ssub_M00844  Arginine biosynthesis, ornithine => arginine [PATH:ssub01230]
Organism
Streptomyces subrutilus [GN:ssub]
KO pathway
ko01230   
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