KEGG   PATHWAY: steq01210
Entry
steq01210                   Pathway                                
Name
2-Oxocarboxylic acid metabolism - Stenotrophomonas sp. 169
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
steq01210  2-Oxocarboxylic acid metabolism
steq01210

Module
steq_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:steq01210]
steq_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:steq01210]
steq_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:steq01210]
steq_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:steq01210]
steq_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:steq01210]
steq_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:steq01210]
Organism
Stenotrophomonas sp. 169 [GN:steq]
Related
pathway
steq00020  Citrate cycle (TCA cycle)
steq00220  Arginine biosynthesis
steq00250  Alanine, aspartate and glutamate metabolism
steq00260  Glycine, serine and threonine metabolism
steq00270  Cysteine and methionine metabolism
steq00290  Valine, leucine and isoleucine biosynthesis
steq00300  Lysine biosynthesis
steq00310  Lysine degradation
steq00620  Pyruvate metabolism
steq00640  Propanoate metabolism
steq00680  Methane metabolism
KO pathway
ko01210   
LinkDB

DBGET integrated database retrieval system