KEGG   PATHWAY: taes00908
Entry
taes00908                   Pathway                                
Name
Zeatin biosynthesis - Triticum aestivum (bread wheat)
Description
Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
taes00908  Zeatin biosynthesis
taes00908

Other DBs
GO: 0009691
Organism
Triticum aestivum (bread wheat) [GN:taes]
Gene
123058494  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
101290602  adenylate isopentenyltransferase 5, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123114770  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123117349  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123065576  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123101319  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123067418  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123120515  adenylate isopentenyltransferase 3, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123175463  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123180738  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123108136  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123125875  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123144059  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123056848  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
101290678  adenylate isopentenyltransferase [KO:K10760] [EC:2.5.1.27 2.5.1.112]
101290601  LOW QUALITY PROTEIN: adenylate isopentenyltransferase 5, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
123116150  cytokinin hydroxylase-like [KO:K10717]
123169838  cytokinin hydroxylase-like [KO:K10717]
123153410  cytokinin hydroxylase-like [KO:K10717]
123124776  cytokinin hydroxylase-like [KO:K10717]
123160811  cytokinin hydroxylase-like [KO:K10717]
123107025  cytokinin hydroxylase-like [KO:K10717]
123058082  cytokinin dehydrogenase 2-like [KO:K00279] [EC:1.5.99.12]
123058083  cytokinin dehydrogenase 2-like [KO:K00279] [EC:1.5.99.12]
100682456  cytokinin dehydrogenase 2 [KO:K00279] [EC:1.5.99.12]
123165939  cytokinin dehydrogenase 11-like [KO:K00279] [EC:1.5.99.12]
123130341  cytokinin dehydrogenase 9 [KO:K00279] [EC:1.5.99.12]
123130577  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
123046080  cytokinin dehydrogenase 8-like [KO:K00279] [EC:1.5.99.12]
123079353  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
123046279  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
123062219  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
123149681  cytokinin dehydrogenase 11-like [KO:K00279] [EC:1.5.99.12]
101290606  cytokinin dehydrogenase 8 [KO:K00279] [EC:1.5.99.12]
123063416  cytokinin dehydrogenase 4 [KO:K00279] [EC:1.5.99.12]
123080639  cytokinin dehydrogenase 4-like [KO:K00279] [EC:1.5.99.12]
101290671  cytokinin dehydrogenase 7 [KO:K00279] [EC:1.5.99.12]
123134105  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
123169883  cytokinin dehydrogenase 10-like [KO:K00279] [EC:1.5.99.12]
542876  cytokinin dehydrogenase 1 [KO:K00279] [EC:1.5.99.12]
123065141  cytokinin dehydrogenase 2-like [KO:K00279] [EC:1.5.99.12]
123154057  cytokinin dehydrogenase 10-like [KO:K00279] [EC:1.5.99.12]
100682455  cytokinin dehydrogenase 2 [KO:K00279] [EC:1.5.99.12]
123121802  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
123157354  cytokinin dehydrogenase 11-like [KO:K00279] [EC:1.5.99.12]
123158090  cytokinin dehydrogenase 10-like [KO:K00279] [EC:1.5.99.12]
101290604  LOW QUALITY PROTEIN: cytokinin dehydrogenase 7 [KO:K00279] [EC:1.5.99.12]
123181110  cytokinin dehydrogenase 3 [KO:K00279] [EC:1.5.99.12]
123053593  cytokinin dehydrogenase 9-like [KO:K00279] [EC:1.5.99.12]
123053961  cytokinin dehydrogenase 8-like [KO:K00279] [EC:1.5.99.12]
123070964  cytokinin dehydrogenase 5-like [KO:K00279] [EC:1.5.99.12]
123181824  cytokinin dehydrogenase 9-like [KO:K00279] [EC:1.5.99.12]
123072395  cytokinin dehydrogenase 4-like [KO:K00279] [EC:1.5.99.12]
123074137  cytokinin dehydrogenase 1-like [KO:K00279] [EC:1.5.99.12]
123057975  cytokinin dehydrogenase 1-like [KO:K00279] [EC:1.5.99.12]
123074275  cytokinin dehydrogenase 2-like [KO:K00279] [EC:1.5.99.12]
123074281  cytokinin dehydrogenase 2-like [KO:K00279] [EC:1.5.99.12]
101290595  cytokinin dehydrogenase 2 [KO:K00279] [EC:1.5.99.12]
123164716  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
123077588  UDP-glycosyltransferase 73C11-like [KO:K13496] [EC:2.4.1.-]
123077947  UDP-glycosyltransferase 73E1-like [KO:K13496] [EC:2.4.1.-]
123094207  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
101290609  UDP-glycosyltransferase 73C5 [KO:K13496] [EC:2.4.1.-]
123166605  UDP-glycosyltransferase 73E1-like [KO:K13496] [EC:2.4.1.-]
101290607  UDP-glycosyltransferase 1 [KO:K13496] [EC:2.4.1.-]
123114256  UDP-glycosyltransferase 73E1-like [KO:K13496] [EC:2.4.1.-]
123114257  UDP-glycosyltransferase 73E1-like [KO:K13496] [EC:2.4.1.-]
123168669  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
123040506  UDP-glycosyltransferase 73E1-like [KO:K13496] [EC:2.4.1.-]
123083984  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
123099339  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
123152056  UDP-glycosyltransferase 73C5-like [KO:K13496] [EC:2.4.1.-]
123152096  UDP-glycosyltransferase 73D1-like [KO:K13496] [EC:2.4.1.-]
123152097  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
123154304  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
123156150  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
123156434  UDP-glycosyltransferase 73C12-like [KO:K13496] [EC:2.4.1.-]
123069073  UDP-glycosyltransferase 73C5-like [KO:K13496] [EC:2.4.1.-]
123104003  UDP-glycosyltransferase 73C12-like [KO:K13496] [EC:2.4.1.-]
123157706  UDP-glycosyltransferase 73C6-like [KO:K13496] [EC:2.4.1.-]
123180686  UDP-glycosyltransferase 73E1-like [KO:K13496] [EC:2.4.1.-]
123105443  UDP-glycosyltransferase 73E1-like [KO:K13496] [EC:2.4.1.-]
123123741  UDP-glycosyltransferase 73E1-like [KO:K13496] [EC:2.4.1.-]
123160674  UDP-glycosyltransferase 1-like [KO:K13496] [EC:2.4.1.-]
123124915  UDP-glycosyltransferase 73C12-like [KO:K13496] [EC:2.4.1.-]
123058031  UDP-glycosyltransferase 73C5-like [KO:K13496] [EC:2.4.1.-]
123164078  UDP-glycosyltransferase 73D1-like [KO:K13496] [EC:2.4.1.-]
123149870  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
123169899  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
123049268  tRNA dimethylallyltransferase 2-like [KO:K00791] [EC:2.5.1.75]
123162461  tRNA dimethylallyltransferase 9-like [KO:K00791] [EC:2.5.1.75]
123185361  tRNA dimethylallyltransferase 2-like isoform X1 [KO:K00791] [EC:2.5.1.75]
123043852  cis-zeatin O-glucosyltransferase 1-like [KO:K13495] [EC:2.4.1.215]
123187636  cis-zeatin O-glucosyltransferase 1-like [KO:K13495] [EC:2.4.1.215]
123166546  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
101290680  cis-zeatin O-glucosyltransferase 1 [KO:K13495] [EC:2.4.1.215]
123046358  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
123046359  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
123046361  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
101664693  cis-zeatin O-glucosyltransferase 1 [KO:K13495] [EC:2.4.1.215]
123190105  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
123190107  cis-zeatin O-glucosyltransferase 2-like [KO:K13495] [EC:2.4.1.215]
123048821  cis-zeatin O-glucosyltransferase 1-like [KO:K13495] [EC:2.4.1.215]
123050132  cis-zeatin O-glucosyltransferase 2-like [KO:K13495] [EC:2.4.1.215]
123154472  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
123067448  cis-zeatin O-glucosyltransferase 2-like [KO:K13495] [EC:2.4.1.215]
123159468  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
123054211  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
123054212  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
123054214  cis-zeatin O-glucosyltransferase 2-like [KO:K13495] [EC:2.4.1.215]
123054215  cis-zeatin O-glucosyltransferase 1-like [KO:K13495] [EC:2.4.1.215]
123041799  cis-zeatin O-glucosyltransferase 1-like [KO:K13495] [EC:2.4.1.215]
123042193  cis-zeatin O-glucosyltransferase 2-like [KO:K13495] [EC:2.4.1.215]
123185860  putative cis-zeatin O-glucosyltransferase [KO:K13495] [EC:2.4.1.215]
123186183  cis-zeatin O-glucosyltransferase 2-like [KO:K13495] [EC:2.4.1.215]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00019  S-Adenosyl-L-methionine
C00020  AMP
C00029  UDP-glucose
C00033  Acetate
C00147  Adenine
C00170  5'-Methylthioadenosine
C00190  UDP-D-xylose
C00235  Dimethylallyl diphosphate
C00371  Zeatin
C00979  O-Acetyl-L-serine
C01513  Lupinate
C01804  Discadenine
C02029  Dihydrozeatin
C03300  O-beta-D-Xylosylzeatin
C03423  O-beta-D-Glucosylzeatin
C04083  N6-(Delta2-Isopentenyl)-adenine
C04432  tRNA containing 6-isopentenyladenosine
C04713  N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
C07330  3-Methyl-2-butenal
C15545  cis-Zeatin
C15546  O-beta-D-Glucopyranosyl-cis-zeatin
C16424  Isopentenyladenosine-5'-triphosphate
C16426  Isopentenyladenosine-5'-diphosphate
C16427  Isopentenyl adenosine
C16428  trans-Zeatin riboside triphosphate
C16429  trans-Zeatin riboside diphosphate
C16430  trans-Zeatin riboside monophosphate
C16431  trans-Zeatin riboside
C16441  cis-Zeatin riboside monophosphate
C16443  trans-Zeatin-7-beta-D-glucoside
C16445  Dihydrozeatin riboside monophosphate
C16447  Dihydrozeatin riboside
C16448  Dihydrozeatin-O-glucoside
C16449  cis-Zeatin riboside
C16467  cis-Prenyl-tRNA
C17324  tRNA adenine
Reference
  Authors
Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  Title
Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  Journal
J Biol Chem 279:14049-54 (2004)
DOI:10.1074/jbc.M314195200
Reference
  Authors
Takei K, Sakakibara H, Sugiyama T.
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J Biol Chem 276:26405-10 (2001)
DOI:10.1074/jbc.M102130200
Reference
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant Cell Physiol 42:677-85 (2001)
DOI:10.1093/pcp/pce112
Reference
  Authors
Takei K, Yamaya T, Sakakibara H.
  Title
Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  Journal
J Biol Chem 279:41866-72 (2004)
DOI:10.1074/jbc.M406337200
Reference
  Authors
Hou B, Lim EK, Higgins GS, Bowles DJ.
  Title
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  Journal
J Biol Chem 279:47822-32 (2004)
DOI:10.1074/jbc.M409569200
Reference
PMID:9874810
  Authors
Martin RC, Mok MC, Mok DW
  Title
Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  Journal
Proc Natl Acad Sci U S A 96:284-9 (1999)
DOI:10.1073/pnas.96.1.284
Reference
  Authors
Martin RC, Mok MC, Mok DW
  Title
A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  Journal
Plant Physiol 120:553-8 (1999)
DOI:10.1104/pp.120.2.553
Reference
  Authors
Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  Title
O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  Journal
Plant Physiol 131:1374-80 (2003)
DOI:10.1104/pp.017210
Reference
  Authors
Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  Title
Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  Journal
Plant Cell 15:2532-50 (2003)
DOI:10.1105/tpc.014928
Reference
  Authors
Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  Title
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 103:16598-603 (2006)
DOI:10.1073/pnas.0603522103
Related
pathway
taes00900  Terpenoid backbone biosynthesis
KO pathway
ko00908   
LinkDB

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