KEGG   PATHWAY: tmc01210
Entry
tmc01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Legionella micdadei
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
tmc01210  2-Oxocarboxylic acid metabolism
tmc01210

Module
tmc_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:tmc01210]
tmc_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:tmc01210]
tmc_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:tmc01210]
Organism
Legionella micdadei [GN:tmc]
Related
pathway
tmc00020  Citrate cycle (TCA cycle)
tmc00220  Arginine biosynthesis
tmc00250  Alanine, aspartate and glutamate metabolism
tmc00260  Glycine, serine and threonine metabolism
tmc00270  Cysteine and methionine metabolism
tmc00290  Valine, leucine and isoleucine biosynthesis
tmc00300  Lysine biosynthesis
tmc00310  Lysine degradation
tmc00620  Pyruvate metabolism
tmc00640  Propanoate metabolism
tmc00680  Methane metabolism
KO pathway
ko01210   
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