KEGG   PATHWAY: wcp01210
Entry
wcp01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Wujia chipingensis
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
wcp01210  2-Oxocarboxylic acid metabolism
wcp01210

Module
wcp_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:wcp01210]
wcp_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:wcp01210]
wcp_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:wcp01210]
wcp_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:wcp01210]
Organism
Wujia chipingensis [GN:wcp]
Related
pathway
wcp00020  Citrate cycle (TCA cycle)
wcp00220  Arginine biosynthesis
wcp00250  Alanine, aspartate and glutamate metabolism
wcp00260  Glycine, serine and threonine metabolism
wcp00270  Cysteine and methionine metabolism
wcp00290  Valine, leucine and isoleucine biosynthesis
wcp00300  Lysine biosynthesis
wcp00620  Pyruvate metabolism
wcp00640  Propanoate metabolism
wcp00680  Methane metabolism
KO pathway
ko01210   
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