Prionailurus bengalensis (leopard cat): 122468034 Help Entry 122468034         CDS       T07574                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism pbg  Prionailurus bengalensis (leopard cat) Pathway pbg04020   Calcium signaling pathway pbg04371   Apelin signaling pathway pbg04713   Circadian entrainment pbg04921   Oxytocin signaling pathway pbg04970   Salivary secretion pbg05010   Alzheimer disease pbg05012   Parkinson disease pbg05020   Prion disease pbg05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pbg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     122468034 (RYR3)    04020 Calcium signaling pathway     122468034 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     122468034 (RYR3)   09154 Digestive system    04970 Salivary secretion     122468034 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     122468034 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     122468034 (RYR3)    05012 Parkinson disease     122468034 (RYR3)    05020 Prion disease     122468034 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     122468034 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pbg04040]     122468034 (RYR3) Ion channels [BR:pbg04040]  Voltage-gated cation channels   Ryanodine receptor    122468034 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  122468034 NCBI-ProteinID:  XP_043410457 LinkDB All DBs Position B3:69177671..69629324 Genome browser AA seq 4897 aa AA seqDB search MKRCQDNSGERRCKKYLMEAGGPSSGWKILQESQGMGMQPWGQDQEDEVVLQCIANIHKE QRKFCLAAEGLGNRLCFLEPTSEAKYVPPDLCVCNFVLEQSLSVRALQEMLANTGENGGE GAAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTI HPASKQRSEGEKVRIGDDLILVSVSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSS IEEGYLLGGHVVRLFHGHDECLTIPSTDQNDAQHRRIFYEAGGAGTRARSLWRVEPLRIS WSGSNIRWGQAFRLRHLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKEIKEKLDS SHKRDIEGMGVPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMD DGLTLQRCQCEESQAARIIRNTTALFSQFVSGNNRTAAPITLPIEEVLQTLQDLIAYFQP PEEEMQHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMA WKEILRLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEA LTLIAEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQ TRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAP YPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPS ISFRINGQPVQGMFENFNTDGLFFPVVSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEA LLPKEKMRLEPVKEYKRDTEGVRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRL AENIHELWGMNKIELGWTFGKTRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLA LGCHIAHVNPAAGEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHN VWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIE PSDQELADPAVEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDV ELGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNK GSELAFADYEIENGFVPICSLGLSQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRD VAMWFSKRLPTFVNVPKDHPHIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYLRLSM PVECHSSFSHSPCLDSDAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDY HLYSEKFDLSKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVATSQRSSRSNVDLEIG CLVDLAMGMLSFSANGRELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSA AIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPSSFLKVETDRVSERHGWVVQCLEPLQMM ALYIPEENRCVDVLELCEQEDLMQFHYHTLRLYSAVCALGNSRVAYALCGHVDLSQLFYA IDNKYLPGLLRSGFYDLLISIHLANAKERKLMMKNEYIIPITSTTRKIRLYPDESKRHGL PGVGLRTCLKPGFRFSTPCFVVTSEEHQKQSPEIPLEILKTKALSMLTEAVQHSGAHIRD PVGGSVEFQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSGEMENRAEKEEVT QVEEKAVEAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDI YVSKLQANQKFRYNELMQALNMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEI REELYDFHEDLLIHCGVPLEEEEEEEEDTSWTGKLRALVYKIKGPTKPAKEQPTEEEERC PTTLKELISQTMIRWAQEDQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVS DTINLLAALGQIRCLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEV MVNVLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMR GSTPLDVAASSVMNNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEG ERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISE NPALDLPSQGYKREVTEDGEYEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEA IRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVY GIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYLCSAVLPLLTRCAPLFA GAEHYTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDV PQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKK YDPDLFRMALPCLSAIAGALPPDYLDTRISATLEKQISVDADGNFDPKPINTMNFSLPEK WEYIVTKYAEHSHDKWACDKSQNGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPAR ESLKTMLAVGWSVERTKEGEALVQQRENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQ GMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQV NGIVVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHD QEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRH RISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKL GKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGVDLLLGDVQISCYHILCSL YSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGM PDTVEEMCPDIPQLEGLMKEISDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHL PPSTGPWCTKVTSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKS HFIPTLEKLKKKAVKTVQEEEQLKADTKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYV DNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKS KMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLA KSRYSYRDTDEEVKEHVRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQR ISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQ RFWIETEEYSFEEKLVQDLAKCPKVEEEEEEETDKHPDPLHQIILHFSRNALTERSKLED DPLYTSYSSMMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQM ISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVL DLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNF LRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIF NSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSNQIELLKELLDLLQD MVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDP DGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFN VAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSAERPEE EEEDEDSSYTLEIEGEEEDDKSFESASAFAMACASVKKNVANFLKKATLKNFRKQYRKVK KMTVKELVKVFFSFFWMLFVGLFQLFFTILGGIFQILWNTVFGGGLVEGAKNIRVTKILG DMPDPTQFGIHDDAMEAERAEVTEPGITPELVHFVKGEKGDADIMSDLFGFRSKKEGGLK HGPEVGLGDLSEIIGKDEPPTLESTVQKKRRAQAAEMKASHEAEGKAEPEKTDMEDGEKE GTAKEEEQADALWAEVTKKKKRRRGQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNL RFLALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYM APALRALAIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKG QWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEESKAE AASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGF KTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMM TCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAF GELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDE TEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14694 nt NT seq  +upstreamnt  +downstreamnt atgaaaagatgtcaggacaatagtggggaaaggagatgcaagaagtacctgatggaggca ggaggaccaagcagtggttggaagatcttgcaggaatcccaggggatggggatgcagccg tggggtcaagatcaggaggatgaagtggttctccagtgcatcgcaaacattcacaaggag cagaggaagttctgcctggcagccgagggcctgggaaaccgcctgtgcttccttgaaccc acttcagaagccaagtatgttcctccagatctctgcgtctgcaattttgtgctggaacag tccctctctgtgagagctctgcaggaaatgcttgccaatacaggtgaaaatggcggcgaa ggggcagcacaagggggtggccacaggaccctgctatatggccacgcgattctcctgcgg cactccttcagcggaatgtatctaacatgtttgaccacatcaagatcccagacagataaa cttgcctttgatgtaggtctacgggaacatgccacaggagaagcctgttggtggaccata catcccgcttccaaacagagatccgagggagagaaagttcgaattggtgatgatctcatc ctcgtcagcgtgtcctctgaaagataccttcatctctccgtatcaaatgggaacatacaa gtggatgcctcttttatgcaaacactctggaatgtacatcccacgtgctcaggaagtagc atcgaagaaggttacctacttggtgggcatgtagtacgtctcttccatggtcatgatgag tgtttgacgataccatctacagaccagaatgacgcccagcacaggaggatattctatgaa gctgggggagctgggacacgagccagatctctgtggagagtggaaccccttcggataagt tggagtggcagtaacatcagatggggccaggctttccgcctccggcatctcaccacaggc cactacctggccttgacagaggaccaaggccttatactgcaggaccgggcaaagtcagac accaagtccacagccttctctttccgggcttccaaggaaatcaaggagaaattggattct agtcacaagcgggatatagaaggcatgggagttccagaaatcaaatatggagattccgtc tgctttgtccagcatatagccagtggtctgtgggtgacctacaaagcacaagatgccaag acctcccgccttggacctctgaaaagaaaggtcatactccatcaggaaggccacatggat gacgggctaacactgcagagatgccagtgcgaggagtcccaggctgctcggatcatccgg aacacgacagccttattcagccagtttgtaagtggaaacaatcgtacggcggcccccatc accctgccgatagaagaggtcctgcagaccttacaggacctgatcgcctacttccagccc ccagaggaggagatgcaacacgaagacaaacagaacaagctccgctcacttaagaacaga cagaatcttttcaaggaagaaggaatgttggcccttgtgttaaactgcatcgatcgctta aacatctacaacagcgtggcgcactttgcaggaattgcaagggaggagagtggcatggct tggaaagagatcctgcgcctgctatacaaactgctggctgctctcattcgtggaaacaga aacaactgtgctcaattctctaataaccttgattggctaatcagcaaattggatagacta gaatcttcctcaggtatcttggaagttttgcactgcatcttgactgaaagcccagaagcc ttaactctgatagcagagggccacatcaagtctatcatctccctgttggataagcatggg cggaatcacaaggttctggatgtgctgtgctccctctgtctctgcaatggggtcgctgtg agagccaaccagaatctgatttgtgacaacttgctgccccggagaaacctgctcctgcag acacggctgattaatgacgtgacaagcattcggccaaacatcttcctgggagttgctgag ggctcagcacagtacaagaagtggtacttcgagctgatcatagaccaagtggaccccttc ctaacagctgagcccacacacctacgggtgggctgggcctcttcctcaggctatgctccg taccctggaggtggagaaggatggggaggcaacggtgttggagacgacctgtattcctat ggctttgatggccttcacctttggtcaggccgcatacccagagccgtggcctccatcaac cagcacctcctgagatcagacgacgtggtaagctgttgcctcgacctcggggtgcccagc atctctttccgcatcaacgggcagcctgtgcaggggatgtttgagaacttcaacacagat gggctcttcttccccgtggtgagcttctcagcaggtgtcaaagtacgtttcctgatgggt ggacgtcatggagaatttaagttcctgcctccctctggctatgccccttgctatgaagcc ttactgccaaaagaaaagatgagattggagcctgtcaaagaatataaacgcgatactgaa ggagttagagatctgttgggtaccactcagttcctctctcaagcctctttcatcccatgc cccatagacaccagtcaggtggttttgccacctcacctagagaagatccgagacagactg gctgaaaacatccacgaactttggggaatgaataaaatagagcttggctggacttttggc aagacacgggatgacaataaaagacaacacccctgtcttgtggagttttcaaagctgcct gaaactgagaagaattataacctacaaatgtcaacggaaaccttaaaaacccttctggcc ctggggtgccacattgctcacgttaatccagctgctggggaggatctcaagaaagtcaag ttgcccaaaaactatatgatgtccaatggctacaagccagcccctttggatttgtctgat gtgaagctattacctcctcaagaaattttggtggataaacttgcagaaaatgcacataat gtttgggccaaagacagaataaaacaaggatggacctatggcatccaacaggatttgaag aacaaaagaaatccccggctggtgccgtacgcattactggatgagcgtacgaagaagtcc aatagggacagccttcgtgaagctgttcgcacatttgttggttatggctataacattgag ccgtcagaccaagaactagctgacccagctgtggagaaagtcagcatagataaaattcga tttttccgggtagagcggtcttacgcagtgagatctggaaagtggtattttgagtttgag gtggtgaccggaggagacatgcgcgttggctgggccaggccgggctgtcggcccgacgtt gagctgggagccgatgatcaagcctttgtgtttgaaggcagcaggggccagcgttggcat caaggcagtgggtattttggacgtacgtggcagccaggagatgtggttggatgtatgatt aaccttgatgatgcttcaatgatcttcacactgaatggggagctgctgattaccaacaaa ggctctgaacttgccttcgctgattatgagattgagaatggcttcgtgcccatctgctct ctgggactgtctcagatcggccgcatgaatcttgggatggatgccagtaccttcaagttt tataccatgtgcggcctccaagagggctttgagccttttgctgtcaacatgaaccgagac gtggcgatgtggttcagcaagcgcctcccgacatttgtcaacgtgccaaaggatcatccg cacatagaggttgtgaggatagatggcactatggacagccctccatgcctcaaggtgacc cacaagacattcggcacacagaatagcaatgccaacatgatctacctacgcctgagcatg cccgtcgaatgccactcctccttcagccacagcccctgcttggacagtgacgcattccag aaaaggaaacagatgcaagaaatactctctcatacaacaacacagtgctactatgcaatc cgcatcttcgctggacaggacccctcctgcgtctgggtcggatgggtgactccggactat cacttgtacagcgagaagtttgacctgagtaaaaactgcacggtgactgttactctaggg gatgaaagaggccgggtccacgaaagcgtgaaacgcagcaactgctacatggtctggggc ggggatattgtggccacttcgcaaagatcaagccggagcaacgtggacctggagatcggc tgcctcgtggatctggcgatgggcatgttgtctttctcagccaatgggagagagctgggt acctgctatcaggtggagcccaataccaaagtgtttccagcagtcttcctgcagcccacg agcacttcattgtttcagtttgaacttgggaagctgaagaatgcgatgcccttgtcggcg gccatatttaagagtgaagagaagaacccagttccgcagtgtccacctcggctggacgtc caaaccatccagcccgtgctctggagccgcatgcccagcagcttcctgaaggtggagaca gaccgggtgagcgagcgccatggctgggtggtgcagtgcctggagcccctgcagatgatg gcgctctacatccctgaggagaacaggtgtgtggatgtcctggagctctgtgagcaggag gacctgatgcagttccattaccacacgctgcgactctacagtgcagtgtgcgccctggga aatagccgcgtggcctatgccctatgcggccacgtggatctctcccagctgttctacgcc attgacaacaagtacctccctggcctccttcgttctggtttctatgacctgctcatcagc atccatctggccaatgctaaggagaggaagctaatgatgaagaatgagtacatcatcccc atcaccagcaccaccagaaaaatccgcctgtatccagatgagtccaagagacacgggctg cctggggtgggcctgagaacgtgcctcaagccagggttcaggttctccaccccttgcttt gtcgtgaccagtgaggagcaccagaagcagagccctgagatccccttggagattctcaaa acaaaggcactgagcatgctgacggaggcagtgcagcacagcggggctcacatccgggac cctgtcggtgggtctgtagagttccagtttgtgcctgtgctgaagctcatcgggaccctg ctggtcatgggggtgtttgatgacgatgacgtcaggcagatcctcctcctgatcgatccc tctgtgtttggggagcacagtggggagatggagaacagagcagagaaggaggaagtgacc caggtggaggagaaggcagtggaggccggagaaaaggccggcaaggaggctccagtcaaa ggcttgttgcagacccgactgccagagtccgtcaagctgcagatgtgtgagctcctcagc tatctctgtgactgtgagctgcagcatcgagtggaggccattgtggcatttggcgacatt tatgtctctaagctccaggcaaatcagaagttccgctacaacgagctcatgcaggccttg aacatgtctgcagccctgactgcccggaaaaccagggagttccgctcacccccccaggag cagatcaacatgcttcttaactttcaactgggagagaattgcccctgcccagaagagatc cgagaggagctatatgacttccatgaggaccttctcattcactgtggtgttcccctggag gaggaagaagaggaggaggaagacacatcctggactgggaaactccgtgccttggtgtat aaaatcaaaggccctaccaagcctgcgaaggaacagccaacagaggaggaagagagatgc cctacgaccttgaaggagctcatctcacagaccatgatccgctgggctcaggaggaccag atccaggatgcagagttggtccggatgatgttcaacctcctccggaggcagtacgacagc attggggagctgctgcaggcgctgcggaagacctacaccatcagtcaggcctccgtgagc gacaccatcaacctgctggccgccctgggccagatccgctgcctcctcagtgtcaggatg ggcaaggaagaggagctgctcatgatcaatgggctgggagacattatgaacaacaaggtg ttctaccagcatcccaacctcatgcgagtccttggcatgcacgagacagtgatggaggtg atggtgaacgtgttggggacagagaagtctcagattgcctttccaaaaatggttgctagc tgttgccgcttcctctgctacttctgtcgaattagccggcaaaatcagaaggccatgttt gagcatctaagttacctgttggagaacagcagtgttggcctagcctccccttcgatgagg ggatctacccctctggatgtggcagcttcctccgtgatgaacaacaatgagttagccctg ggcttagaggaaccagaccttgagaaggtggtgacctacttggcaggctgtggcctgcag agctgccccatgcttctagccaaagggtaccctgacgtcggctggaaccccatcgaaggg gagcgctacctgtccttcctgaggtttgccgtctttgtgaacagtgaaagtgtggaagaa aatgctagcgtcgtggtcaagctgctcatcagacgcccagagtgcttcggcccagccttg cgaggtgaaggaggaaacggtctattggcagccatgcagggtgccattaagatctctgag aacccagctctcgacctcccctctcagggatataagagagaagtcacggaggacggtgaa tatgaagaagagatcgtccacatgggcaatgcaattatgtctttctattcagcccttata gatctcctgggccgctgtgctcctgaaatgcatcttatccagacaggaaagggggaagcc atccggatcaggtcaatcctgcgctccctggtccccactgaggacctggttgggatcatc agcatccccttgaagctgccttccctgaacaaagatgggtcggtcagcgagccagatatg gcagccaacttctgccctgaccacaaggcacccatggtgctgttcttggatcgtgtttat ggcattaaggatcaaacttttctgctccacttgctagaggttggatttttacctgactta agagcctctgcctctctagatacagtttccctaagcaccacagaggctgcgcttgcacta aataggtatctatgttctgctgtgcttccgctcctcacaagatgcgcccctctctttgcc ggagcagaacactacacctctttgatcgattctacactacagacaatatataggctttcc aagggacgttccctcaccaaagctcagagggacaccatagaagaatgtttgcttgccatt tgcaatcacttgaggccttcaatgctacagcaactcttgcgacgtcttgtctttgacgtg ccgcagctcaacgaatactgcaaaatgcctcttaagcttctgacaaatcactatgaacag tgctggaagtattactgtctgccttcaggatgggggagctacgggctagctgtggaagag gaattgcacctgacggagaagctcttctgggggattttcgactccctctcccataagaag tatgacccagaccttttccgaatggcccttccttgtctcagtgctatagctggggcgcta ccaccagattacttagataccagaatctcagccacgttggagaaacagatctcagtggat gcagatggcaactttgaccccaaacccatcaacaccatgaatttttccttgcctgaaaaa tgggagtacatcgtcaccaagtacgcggagcattcacatgataaatgggcctgtgacaag agtcagaatggatggaaatatggaatttccctggatgaaaatgtgaagacccatcccctg ataaggcctttcaagacattaacagaaaaggagaaggaaatttaccgctggcctgctaga gagtccctgaaaaccatgctggctgtgggctggtctgtggagaggaccaaagagggagag gccctggtgcaacagcgggaaaatgagaagcttcggagcgtgtcccaggccagccagggc aacagctacagtcctgctcccctggacctctccaacgttgtgctctccagggagctccag ggaatggtggaggtcgtggctgagaactatcacaacatctgggccaagaagaagaagctg gaactggagagcaaaggtggcggcagtcaccctctgttggtaccatatgacaccttgacg gccaaggagaagttcagggaccgagaaaaggcacaggacctgtttaaattcctccaggtg aacggcatcgtggtttctagaggtatgaaggatatggagctggatgcctcctccatggaa aagaggtttgcctataaatttttgaagaagatcctgaaatatgttgattccgcccaagag tttattgcccatttggaagccattgtcagcagtgggaaaactgaaaagtctccccatgac caggagatcaaattctttgccaaagttctcctcccactggttgaccagtacttcacaaat caccgcctctacttcctgtcatcccctctaaaacccctcagcagcagtggctatgcctcc cataaggagaaagaaatggtggccagcctgttctgcaaactcgctgctcttgttcgacac aggatttccctctttggaagtgattctactacaatggtgagctgtcttcacatcttagct cagacacttgacacaaggactgtcatgaagtcaggctcagagctggtgaaggctgggtta cgagctttctttgaaaatgcggcggaagacttagagaagacttcggaaaatctgaagctc gggaagtttacgcattccagaacacagattaaaggcgtgtctcagaatattaactatacc acggtggctctgctccccatcctgacgtccatctttgagcatgttgctcagcatcagttc ggggtggatttactcttaggtgatgtgcagatttcatgctaccacatactctgcagtctc tactcccttgggaccggaaagaacatctatgttgaaaggcaacgtcctgcccttggagaa tgtctggcctcactggcagctgccataccagtggcattcttggagcccactcttaaccgc tacaatccactctcagtcttcaacaccaaaacccccagagagaggtctattctggggatg ccagacacagtggaagagatgtgtcctgacatccctcagctggaaggcctgatgaaggaa atcagcgacctggccgagtcaggggcccggtacacggagatgccccacgtcatcgaggtg atcttgcccatgctgtgcaactacctgtcctactggtgggagcgggggccggagcacctg ccccccagcacggggccctggtgcaccaaggtcacctctgaacacctcagtgtcatcctg ggaaacattctgaaaatcatcaacaacaacctgggcatcgacgaggcatcctggatgaag cgcatcgcagtgtatgcccagccaatcatcagcaaagccaggccggacctgctgaaaagc cacttcatcccaactctggagaagctgaagaaaaaggctgtgaagactgtgcaggaggag gagcagctgaaggccgacaccaaaggagacactcaggaggcggagctcctcatcctggat gagtttgcagtcctctgcagagacctctacgccttctaccccatgctcatccgctacgtg gacaacaacagatcgaactggctcaaaagtcccgatgctgattctgaccagctcttccgc atggtggcagaggtcttcatcctgtggtgcaaatctcacaacttcaagagggaagagcaa aattttgtgattcagaatgaaattaataatttggcatttttaactggagacagcaaaagc aagatgtcgaaagccatgcaagtaaagtctggaggacaggaccaggaacggaagaagacc aagcggaggggagacttgtactccatccagacctctctcatcgtggctgcactcaagaaa atgctgcccattggtttgaatatgtgcacgccaggcgatcaggagctaatctcccttgca aagtcacgatacagctatagggacaccgatgaagaggtgaaagaacacgtgcggaataac ttgcacctgcaggaaaagtcagatgacccagcagtaaagtggcagctgaacctctacaaa gatgttttgaagagtgaagaaccttccaatccagaaaagaccgtagagcgcgtacagaga atttccgcagctgtcttccatctggagcaggtcgaacagcctttgaggtccaagaaggca gtctggcacaaactgttatcaaagcagcggaaacgggcagtggtggcctgtttcaggatg gcccctctgtacaacttgcccaggcaccgctccattaacctcttcctccatggctatcag agattttggatagaaacagaggagtattcctttgaagagaaactagtacaggacttggct aaatgccccaaggtggaagaggaggaggaggaggagacagacaagcacccagacccactt catcagatcattctccattttagccgcaatgctctcacggagaggagcaaattggaagac gaccccttgtacacctcctattccagcatgatggccaagagttgtcagagtggggaggac gaagaagaagacgaagacaaggaaaagacatttgaagagaaggaaatggaaaagcagaaa accctctaccaacaagctcgactgcatgagcgtggagctgcagagatggtcctccagatg ataagtgccagcaaaggtgagatgagccccatggtggttgagactctgaagctggggatc gccattctgaatgggggcaacgctggtgtacaacagaaaatgctagattacctaaaggag aaaaaggatgctggattctttcaaagcctttccggccttatgcagtcttgcagtgtcctt gatttgaatgcatttgagaggcagaataaagctgaaggcctggggatggttactgaggaa ggaacactcattgtccgtgagcgtggtgaaaaagtactccagaatgacgagtttacacga gatctctttagattcctgcagttactttgtgaaggacataacagtgacttccagaacttc ctgcggactcagatgggcaacaccaccactgtaaatgtcatcatcagtaccgtggactat ctcctgcgtctgcaggaatcaatcagtgatttctactggtattattcagggaaggacatc attgatgaatctggacagcacaacttttccaaagctctggcagtcacgaagcagattttc aattctcttacagaatacatccagggcccttgcattgggaaccaacagagcctggctcac agcaggctgtgggatgcagtggtcggcttcctgcacgtatttgctaacatgcagatgaaa ctctctcaggattccaatcagatcgagctgctgaaggaactcttggatctccttcaggac atggtggtgatgcttctgtccctcctggaagggaatgtggtaaatggaactattggcaag cagatggttgacacgctggtagagtcatctaccaatgtagaaatgatcttgaaattcttt gacatgttcttgaaacttaaagacctaaccagctcagacaccttcaaagaatatgaccca gatggtaaagggattatctccaaaaaagaattccagaaggccatggaagggcaaaaacag tacacacagtcagagattgactttctcctttcatgcgcagaagctgatgagaatgatatg tttaattacattgattttgtagaccggtttcatgagccggccaaggacatagggtttaat gtggcagtgttattgacaaatctctccgaacacatgccaaatgattctcgccttaagtgc ctattggacccagcggaaagtgtactaaattacttcgaaccctacctaggacgtattgag atcatgggcggggccaagaaaattgagcgcgtttattttgagatcagtgaatccagtcga acccagtgggagaagccccaagtgaaggaatctaagcggcagttcatctttgatgtggtc aatgaaggtggagagcaagaaaagatggaactgtttgtgaacttctgtgaggataccatc tttgaaatgcagttagcgtctcagatctctgaatctgactcagccgaaaggccagaagag gaggaggaagatgaagattcttcttacacgttagaaattgagggggaagaggaggatgac aagtcttttgagtctgcctctgcatttgccatggcctgtgcctcagtgaagaaaaacgtt gccaacttcctgaagaaggcaaccctgaagaacttcaggaagcagtacaggaaggtgaag aagatgaccgtgaaggagctggtgaaggtgttcttctctttcttctggatgttatttgtg gggctattccagttgttcttcaccatattgggaggaatctttcagatcctctggaacaca gtgtttggagggggcctagtggaaggggcaaagaacatcagagtgaccaagatcctgggt gacatgcctgacccaacccagtttggtatccatgatgatgccatggaggctgagcgggca gaggtgactgagccaggtattacaccagaactagtccacttcgtcaagggtgagaaagga gatgcagatatcatgtcagatctctttggattccgctcaaagaaagaaggtggcttaaag catgggcctgaagtgggtttgggtgatctctctgagattattggcaaggatgaaccccct acactagagagtactgtacagaagaaaaggagagcacaggcagcagaaatgaaagcatca catgaagcagaaggaaaagcggagcctgagaagacagacatggaagatggggagaaggag ggtacggccaaggaggaagagcaagctgacgccctgtgggcagaagtgacaaagaagaag aagcggcgacggggccagaaagttgagaagcctgaagccttcatggctaatttcttcaaa gggctggaaatctatcagaccaagttactgcattacctggccaggaatttctacaacctg aggttcctcgctctgtttgtagccttcgctatcaacttcatcctgctcttttacaaggtc actgaagagcctttagaagaagagacagaggacgttgcaaacctgtggaattcctttaat gatgaggaagaggaagaagcgatggtgttctttgtcctacaggagagcaccgggtatatg gcaccagcactgcgggccttggccattatccacaccatcatctctttggtctgtgtggtg ggctattactgcctgaaggtccctttggtggtgttcaaaagagaaaaagaaattgccagg aagctggagttcgatggcctgtatatcactgaacagccatctgaagatgacatcaagggg cagtgggaccgcttggtaatcaacacaccatcttttcctaataactactgggacaagttt gtaaagagaaaggtgattaacaagtatggtgatctctacggagcagaacgcattgctgaa ctcctaggtttggacaaaaatgcccttgatttcagcccagtagaagaaagcaaagcagag gcggcctctctggtgtcatggctgagttccatcgatatgaagtaccatatctggaagctg ggagttgtttttaccgataactcctttctctaccttgcctggtatacaaccatgtcgatc ctgggccactacaacaacttcttctttgctgcccatctgctagacattgcaatgggcttc aagacgctgaggactattctgtcatctgtaactcacaacggcaaacagctggttctgact gtgggtctcctggccgtggtggtttacctctacaccgtggtggccttcaacttcttccgc aagttctacaacaaaagtgaagatgacgatgagcctgatatgaagtgtgacgacatgatg acgtgttacctattccacatgtatgtgggagtaagagcaggaggcggcattggcgacgaa attgaagaccctgctggtgatccttatgaaatgtaccgcattgtcttcgacatcacgttc ttcttctttgtcattgtcatcttgctggccatcattcaaggtcttattattgatgctttt ggagagttaagagaccagcaggaacaggtgcgagaagatatggagactaaatgtttcatc tgcgggattggcaatgactactttgacacgacccctcatggttttgaaacacacacctta caggagcacaacttagccaactatttgttcttcctgatgtatctgattaacaaagatgaa acagaacacacgggtcaggaatcttatgtctggaagatgtaccaagaaaggtgttgggat ttcttcccagctggtgactgctttcggaaacaatatgaagatcagcttggataa

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