KEGG   Prionailurus bengalensis (leopard cat): 122468485
Entry
122468485         CDS       T07574                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pbg  Prionailurus bengalensis (leopard cat)
Pathway
pbg01521  EGFR tyrosine kinase inhibitor resistance
pbg01522  Endocrine resistance
pbg04010  MAPK signaling pathway
pbg04012  ErbB signaling pathway
pbg04014  Ras signaling pathway
pbg04015  Rap1 signaling pathway
pbg04022  cGMP-PKG signaling pathway
pbg04024  cAMP signaling pathway
pbg04062  Chemokine signaling pathway
pbg04066  HIF-1 signaling pathway
pbg04068  FoxO signaling pathway
pbg04071  Sphingolipid signaling pathway
pbg04072  Phospholipase D signaling pathway
pbg04114  Oocyte meiosis
pbg04140  Autophagy - animal
pbg04148  Efferocytosis
pbg04150  mTOR signaling pathway
pbg04151  PI3K-Akt signaling pathway
pbg04210  Apoptosis
pbg04218  Cellular senescence
pbg04270  Vascular smooth muscle contraction
pbg04370  VEGF signaling pathway
pbg04371  Apelin signaling pathway
pbg04380  Osteoclast differentiation
pbg04510  Focal adhesion
pbg04540  Gap junction
pbg04550  Signaling pathways regulating pluripotency of stem cells
pbg04613  Neutrophil extracellular trap formation
pbg04620  Toll-like receptor signaling pathway
pbg04650  Natural killer cell mediated cytotoxicity
pbg04660  T cell receptor signaling pathway
pbg04662  B cell receptor signaling pathway
pbg04664  Fc epsilon RI signaling pathway
pbg04666  Fc gamma R-mediated phagocytosis
pbg04668  TNF signaling pathway
pbg04720  Long-term potentiation
pbg04722  Neurotrophin signaling pathway
pbg04725  Cholinergic synapse
pbg04726  Serotonergic synapse
pbg04730  Long-term depression
pbg04810  Regulation of actin cytoskeleton
pbg04910  Insulin signaling pathway
pbg04912  GnRH signaling pathway
pbg04914  Progesterone-mediated oocyte maturation
pbg04915  Estrogen signaling pathway
pbg04916  Melanogenesis
pbg04917  Prolactin signaling pathway
pbg04919  Thyroid hormone signaling pathway
pbg04921  Oxytocin signaling pathway
pbg04926  Relaxin signaling pathway
pbg04928  Parathyroid hormone synthesis, secretion and action
pbg04929  GnRH secretion
pbg04934  Cushing syndrome
pbg04935  Growth hormone synthesis, secretion and action
pbg05010  Alzheimer disease
pbg05022  Pathways of neurodegeneration - multiple diseases
pbg05034  Alcoholism
pbg05132  Salmonella infection
pbg05135  Yersinia infection
pbg05160  Hepatitis C
pbg05161  Hepatitis B
pbg05163  Human cytomegalovirus infection
pbg05164  Influenza A
pbg05165  Human papillomavirus infection
pbg05166  Human T-cell leukemia virus 1 infection
pbg05167  Kaposi sarcoma-associated herpesvirus infection
pbg05170  Human immunodeficiency virus 1 infection
pbg05200  Pathways in cancer
pbg05205  Proteoglycans in cancer
pbg05206  MicroRNAs in cancer
pbg05207  Chemical carcinogenesis - receptor activation
pbg05208  Chemical carcinogenesis - reactive oxygen species
pbg05210  Colorectal cancer
pbg05211  Renal cell carcinoma
pbg05212  Pancreatic cancer
pbg05213  Endometrial cancer
pbg05214  Glioma
pbg05215  Prostate cancer
pbg05216  Thyroid cancer
pbg05218  Melanoma
pbg05219  Bladder cancer
pbg05220  Chronic myeloid leukemia
pbg05221  Acute myeloid leukemia
pbg05223  Non-small cell lung cancer
pbg05224  Breast cancer
pbg05225  Hepatocellular carcinoma
pbg05226  Gastric cancer
pbg05230  Central carbon metabolism in cancer
pbg05231  Choline metabolism in cancer
pbg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pbg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122468485 (MAP2K1)
   04012 ErbB signaling pathway
    122468485 (MAP2K1)
   04014 Ras signaling pathway
    122468485 (MAP2K1)
   04015 Rap1 signaling pathway
    122468485 (MAP2K1)
   04370 VEGF signaling pathway
    122468485 (MAP2K1)
   04371 Apelin signaling pathway
    122468485 (MAP2K1)
   04668 TNF signaling pathway
    122468485 (MAP2K1)
   04066 HIF-1 signaling pathway
    122468485 (MAP2K1)
   04068 FoxO signaling pathway
    122468485 (MAP2K1)
   04072 Phospholipase D signaling pathway
    122468485 (MAP2K1)
   04071 Sphingolipid signaling pathway
    122468485 (MAP2K1)
   04024 cAMP signaling pathway
    122468485 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    122468485 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    122468485 (MAP2K1)
   04150 mTOR signaling pathway
    122468485 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122468485 (MAP2K1)
   04148 Efferocytosis
    122468485 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    122468485 (MAP2K1)
   04210 Apoptosis
    122468485 (MAP2K1)
   04218 Cellular senescence
    122468485 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122468485 (MAP2K1)
   04540 Gap junction
    122468485 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    122468485 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122468485 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122468485 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    122468485 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    122468485 (MAP2K1)
   04660 T cell receptor signaling pathway
    122468485 (MAP2K1)
   04662 B cell receptor signaling pathway
    122468485 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    122468485 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    122468485 (MAP2K1)
   04062 Chemokine signaling pathway
    122468485 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122468485 (MAP2K1)
   04929 GnRH secretion
    122468485 (MAP2K1)
   04912 GnRH signaling pathway
    122468485 (MAP2K1)
   04915 Estrogen signaling pathway
    122468485 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    122468485 (MAP2K1)
   04917 Prolactin signaling pathway
    122468485 (MAP2K1)
   04921 Oxytocin signaling pathway
    122468485 (MAP2K1)
   04926 Relaxin signaling pathway
    122468485 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    122468485 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    122468485 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    122468485 (MAP2K1)
   04916 Melanogenesis
    122468485 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122468485 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    122468485 (MAP2K1)
   04726 Serotonergic synapse
    122468485 (MAP2K1)
   04720 Long-term potentiation
    122468485 (MAP2K1)
   04730 Long-term depression
    122468485 (MAP2K1)
   04722 Neurotrophin signaling pathway
    122468485 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122468485 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122468485 (MAP2K1)
   05206 MicroRNAs in cancer
    122468485 (MAP2K1)
   05205 Proteoglycans in cancer
    122468485 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    122468485 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122468485 (MAP2K1)
   05230 Central carbon metabolism in cancer
    122468485 (MAP2K1)
   05231 Choline metabolism in cancer
    122468485 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122468485 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122468485 (MAP2K1)
   05212 Pancreatic cancer
    122468485 (MAP2K1)
   05225 Hepatocellular carcinoma
    122468485 (MAP2K1)
   05226 Gastric cancer
    122468485 (MAP2K1)
   05214 Glioma
    122468485 (MAP2K1)
   05216 Thyroid cancer
    122468485 (MAP2K1)
   05221 Acute myeloid leukemia
    122468485 (MAP2K1)
   05220 Chronic myeloid leukemia
    122468485 (MAP2K1)
   05218 Melanoma
    122468485 (MAP2K1)
   05211 Renal cell carcinoma
    122468485 (MAP2K1)
   05219 Bladder cancer
    122468485 (MAP2K1)
   05215 Prostate cancer
    122468485 (MAP2K1)
   05213 Endometrial cancer
    122468485 (MAP2K1)
   05224 Breast cancer
    122468485 (MAP2K1)
   05223 Non-small cell lung cancer
    122468485 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122468485 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    122468485 (MAP2K1)
   05161 Hepatitis B
    122468485 (MAP2K1)
   05160 Hepatitis C
    122468485 (MAP2K1)
   05164 Influenza A
    122468485 (MAP2K1)
   05163 Human cytomegalovirus infection
    122468485 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122468485 (MAP2K1)
   05165 Human papillomavirus infection
    122468485 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122468485 (MAP2K1)
   05135 Yersinia infection
    122468485 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122468485 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    122468485 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    122468485 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    122468485 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122468485 (MAP2K1)
   01522 Endocrine resistance
    122468485 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pbg01001]
    122468485 (MAP2K1)
Enzymes [BR:pbg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     122468485 (MAP2K1)
Protein kinases [BR:pbg01001]
 Serine/threonine kinases: STE group
  STE7 family
   122468485 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 122468485
NCBI-ProteinID: XP_043411043
LinkDB
Position
B3:complement(38951763..39030363)
AA seq 371 aa
MKLERTNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC
MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG
EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP
IPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP
PKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDGEEVDFAGWLCSTIGLN
QPSTPTHAAGV
NT seq 1116 nt   +upstreamnt  +downstreamnt
atgaagctggagaggaccaacctggaggccttgcagaagaagctggaggagctggagctc
gatgagcagcaacggaagcgcctggaggcctttcttacccagaagcagaaggtcggggaa
ttgaaggatgatgacttcgagaagatcagcgagctgggcgccggcaacggtggtgtggtg
ttcaaggtctcccataagccgtctggcctggtcatggccagaaagctaattcacctggag
atcaaacctgcaatccggaaccagatcataagggagctgcaggttctacatgagtgcaac
tccccatacatcgtgggcttctatggcgcgttctacagcgacggcgagatcagtatctgt
atggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaagaattcct
gaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctgagggag
aagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactctcgtggg
gagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggccaactcc
ttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattactccgtg
cagtcggacatctggagcatggggctatctctggttgagatggcagtcgggaggtatccc
atccctcctcccgatgccaaggagctggagctgatgtttgggtgccaagtggagggagat
gcggctgagacgccacccaggccgaggacccccggaaggcccctcagctcgtatggaatg
gacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgagcctcct
ccaaagctgcccagtggagtattcagtctggaatttcaagattttgtgaataaatgcctc
ataaaaaacccagcagagagagcagatctgaaacaactcatggttcatgcctttatcaag
agatctgatggtgaggaagtggattttgcaggttggctctgctccaccatcggccttaac
cagcccagtacaccgacccacgcggccggcgtctaa

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