Prionailurus bengalensis (leopard cat): 122471824 Help Entry 122471824         CDS       T07574                                  Symbol TSC2 Name (RefSeq) tuberin isoform X1   KO K07207   tuberous sclerosis 2 Organism pbg  Prionailurus bengalensis (leopard cat) Pathway pbg04072   Phospholipase D signaling pathway pbg04115   p53 signaling pathway pbg04140   Autophagy - animal pbg04150   mTOR signaling pathway pbg04151   PI3K-Akt signaling pathway pbg04152   AMPK signaling pathway pbg04211   Longevity regulating pathway pbg04218   Cellular senescence pbg04714   Thermogenesis pbg04910   Insulin signaling pathway pbg04919   Thyroid hormone signaling pathway pbg05163   Human cytomegalovirus infection pbg05165   Human papillomavirus infection pbg05168   Herpes simplex virus 1 infection pbg05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:pbg00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     122471824 (TSC2)    04151 PI3K-Akt signaling pathway     122471824 (TSC2)    04152 AMPK signaling pathway     122471824 (TSC2)    04150 mTOR signaling pathway     122471824 (TSC2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     122471824 (TSC2)   09143 Cell growth and death    04115 p53 signaling pathway     122471824 (TSC2)    04218 Cellular senescence     122471824 (TSC2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     122471824 (TSC2)    04919 Thyroid hormone signaling pathway     122471824 (TSC2)   09149 Aging    04211 Longevity regulating pathway     122471824 (TSC2)   09159 Environmental adaptation    04714 Thermogenesis     122471824 (TSC2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     122471824 (TSC2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     122471824 (TSC2)    05163 Human cytomegalovirus infection     122471824 (TSC2)    05165 Human papillomavirus infection     122471824 (TSC2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:pbg01009]     122471824 (TSC2) Protein phosphatases and associated proteins [BR:pbg01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      122471824 (TSC2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP HEAT Cnd1 Motif Other DBs NCBI-GeneID:  122471824 NCBI-ProteinID:  XP_043416867 LinkDB All DBs Position E3:complement(40009099..40044103) Genome browser AA seq 1809 aa AA seqDB search MAKPTSKDSGLKEKFRILFGLGTPRPNPRSAEGKQTEFIITAEILRELSVECGLNNRIRV IGQICEVAKTKKFEEHAVEALWKAVEDMLQPERPPEARHAVLALLKAIVQGQGDRLGVLR ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAGFVLQWMDIGLSSEFLLVL VNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFI VTLCRTVNVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMEDRAYMEDAPLLRGAVFFVG MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSVTRLIKKYRRELQAVTWDI LLDIIERLLQQLQSLDSPELRAIVHDLLTTVEELCDQNEFHGSHERYFELVERCADQRPE SSLLNLITYRAQSIHPAKDGWIHNLQLLMERFFRNESRSAVRIKVLDVLSFVLLINRQFY EEELISSVVISQLSHIPEDKDPQVRKLATQLLVDLAEGCHTHHFNSLLDIVEKVMARSLS APPELEERDVVAYSASLEDVKTAVLGLLVILQTKLYALPASHAVRVYETLVSHLQLHYKH GYTLPIASSIRLQAFDFLLLLRADSLHRLGLPSKDGAVRFSPYCVCDSTEPERGSEKKAG GPLSPPTGPSGPAPAGPAVRLGSLPYSLLFRVLLQCLKQETDWKVLKLVLGKLPESLRFK VLIFTSPCSVDQLSSALCSMLSGPRTLERLRGTPEGFSRTDLHLAVVPVLTALISYHNYL DKARQREMVYCLEQGLIYRCASQCVVALAVCSVEMPDIIIKALPVLVVKLTHISATASMA IPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC RLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS PPVREFQESSAADAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHL ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL LGLDSGELQGSPELSSDPSAHVRQTKEAPAKLESQAGQQVCRGARDRVRSMSGGHGLRVG ALDAPATHCPGAQTTPASTSERASAAAQLPAQEKTSLAAYVPLLTQGWAEILVRRPTGNT SWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKERRDTALYKSLSVPAAGSAKPPPP PRSNTVASFSSLYQTSCQGELHRSISWADSAVVLEEGSPSETDLPGEPTELEDFEATLGP ERRCRRPEAYSRSSSSSSQEEKSFAAEEVAAGGLPIGRAVSAEGARPSAGLSFQPAQPLS KSSSSPELQTLQDTLGDPGDKADVGRLSPEAKARSQSGTLDGAGATWSTPGEESQGRGPA RPEGPLPSGCPRSPGGLRPRGYTISDSAPSRRGKRVERDAFKSRAGASNTEKVPGINPSF VFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSSSELAI LSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHI ATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIITPLDYECN LVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWI ARLRHIKRLRHRVGQIREEAHYSNPSLPLTQTHPPGHAKAPAPAEPMPTYETGQRKRLIS SVDDFTEFV NT seq 5430 nt NT seq  +upstreamnt  +downstreamnt atggccaagccgacaagcaaggattcaggcttgaaggagaagttcaggattctgtttgga ctgggaaccccgcggccaaaccccaggtctgcagagggcaagcagacggagtttatcatc acggcggaaatcctgagagagctgagcgttgaatgtggcctcaacaatcgcatccgggtg atagggcagatctgtgaagttgcaaaaacgaagaagtttgaagagcatgcagtggaagcg ctctggaaggccgtcgaggacatgctgcagccagagcggccaccggaggcccggcatgcg gtgctggctctgctgaaggccatcgtgcaggggcagggggaccgcttgggcgttctcagg gccctcttctttaaggtcatcaaggattacccctctaatgaagatctccacgaaagactg gaagttttcaaggccctcacagacaatgggagacacatcacatatttggaagaagaactg gctgggtttgtgctgcagtggatggacatcggcctgtcctcagagttccttctggtgctt gtgaacttggtcaaattcaacagctgttacctggatgaatacatcgcatcaatggtccac atgatctgcctgctgtgcgtccagactgtgtcctccgtggacatagaggtctctctgcag gtgctggacgccgtcgtctgctacaactgtctgccggctgagagcctgcccctgttcatc gtcactctctgtcgtaccgtcaacgtcaaggagctctgtgagccttgctggaagctgatg cgtaatcttctgggcacccacctgggtcacagtgccatctacaacatgtgccgcatcatg gaggacagagcctacatggaagacgccccgctgctgagaggggccgtgttctttgtgggc atggctctctggggggcgcaccgactctactcgctcaagaactccccgacatccgtgctg ccgtcgttctatgaggccatgacctgtccgaacgaggtggtgtcctatgaaatcgtcctg tctgtcaccagactcatcaagaagtaccggagggagctccaggctgtgacgtgggacatc ctgctggacatcatcgaacgtctgctgcagcagctccagagcctggacagcccggagctc agagccatcgtccatgacctgctgaccacagtggaggagctgtgtgaccagaatgagttc cacggctcgcacgagagatacttcgagctcgtcgagagatgtgcagaccagaggccggag tcctccctcctaaacttaataacctacagggctcagtccatccatccggcaaaggacggc tggattcacaacctgcagttactgatggagagattcttccggaatgaatcccgcagtgct gtgcgcatcaaggtgctcgacgtcttgtcctttgtgctgctcatcaacaggcagttctat gaggaggagctgatcagctcggtggtcatctctcagctctcccacatcccggaggacaaa gacccccaagtccggaaactggccacccagttgctggtggacctggccgaaggctgtcac acccaccacttcaacagcctgctggacattgtggagaaggtgatggcccgctccctttcc gcaccccctgagctggaggaaagagatgtggtggcatattcagcctccttagaggatgtg aagactgccgtcttggggctcctggtgatccttcagaccaagctgtacgccttgcctgcc agccacgcggtgcgtgtgtacgagaccctcgtcagccacctgcagctccactacaagcac ggctataccctgcccatcgccagtagcatccggctgcaggcctttgacttcctgctgctg ctgagggcggactccctgcaccgcctcggcctgcccagcaaggacggggctgtgaggttc agcccctactgcgtctgcgactccacggagccagagagaggctctgagaagaaggccggc ggccccctgtcgcctcccaccgggccgtccggcccagcacctgccggtcccgctgtgcgg cttggctccctgccctactccctgctcttccgggtcctgctgcagtgcttaaagcaggag acggactggaaggtgctgaagcttgttctcggcaagctgcccgagtccctgcgcttcaag gtcctcattttcacgtccccgtgcagcgtcgaccagctgtcttccgccctctgctccatg ctttcaggtcccagaactctggagcggctccgaggcaccccggaaggtttctccaggacc gacctgcacctggctgtggttcctgtgctgacggcgttaatctcttaccataactatttg gacaaagccagacagcgggagatggtgtactgcctggagcaaggcctgatctaccgctgt gccagccagtgcgtggtggccctggccgtgtgcagcgtcgaaatgcccgacatcatcatc aaggcgctgcctgtcttggtcgtgaagctcacacacatttcggccacagccagcatggcc attccactcctcgaattcctgtcaactctggccaggctgcctcacctctacaggaacttt gccgctgagcagtacgcgagtgtgtttgccatctccctgccgtacaccaacccctccaag tttaatcagtacatcgtgtgcctggcccatcacgtcatagccatgtggttcattagatgc cgtctgccttttcggaaggattttgttccttatatcactaagggcctacgctccaatgtc ctcctgtcttttgatgacaccccggagaaggacagcttcagagcgcggagcaccagtctc aacgagaggcccaagagtttgaggatagccagaccccccaaacaaggcttgaataactcc ccacccgtgagagaattccaggagagctctgcagccgacgccttccggtgccgcagcatc agtgtgtctgaacatgtggtccgcagcaggatccagacgtccctcacgagtgccagcttg gggtctgcggacgagaactcaatggcccaggctgacgacaacttgaaaaatctccacctg gagctcacggagacttgtctggacatgatggccagatacgtgttctccaacttcacggcg gtccccaagaggtcccctgtaggggagttcctcttggctggtggcaggaccaagacctgg ctggttggaaacaagctcgtcaccgtgacgacgagcgtggggaccgggacccggtcactg ctgggcttggactcaggagagctgcagggcagcccagagctgagctctgaccccagtgcg catgtgaggcagacaaaggaggcgcctgccaagttggagtcccaggctgggcagcaggtg tgccgtggggcccgggaccgcgtccgctccatgtctgggggccacggccttcgtgttggt gccttggacgctcccgccacccactgcccaggcgcacagaccacaccggccagcacgtcc gagagggcctcggctgccgcccagctcccggcgcaggagaagacgagcctggcggcctac gtacccctgctgacccagggctgggcggagatcttggtccggaggcccacggggaacacc agctggctgatgagcctggagaaccccctcagccccttctcctcggacatcaacaacatg cccctgcaggagctgtccaacgccctcatggccgccgaacgcttcaaggagcgtcgtgac acggccctgtacaagtcactttcggtgccggcggccggctccgccaagccccctccgccc ccacgttctaacacagtggcctctttctcctccctgtaccagaccagttgccaaggagag ctgcacaggagcatttcctgggcagactccgcggtggttctggaggagggaagtcccagc gagactgatttgccaggcgagcccactgagctggaggactttgaggccaccctgggccca gagaggcgctgtcggcgccctgaagcctacagtagatcgtcttccagctccagccaagag gagaagtctttcgccgcagaggaggtggctgccggagggctccccatcgggcgggccgtg tctgccgagggagcccggccctctgcggggctctccttccagcccgcccagcccctcagc aagtctagctcctcgccggagctgcagaccctacaggatacactcggggaccctggggac aaggccgacgttggccggctgagccccgaggccaaggcccgctcacagtccgggactctg gacggggcaggtgccacctggtcaaccccaggtgaagagagtcagggccggggccctgcg aggcccgagggtcccttgccttctggctgtccccgttcccccggtggcctgcgtcccaga ggctacaccatttcggattcagccccgtcacgcagaggcaagagggtagagcgggacgcc ttcaagagcagagctggggcctccaatactgagaaggtgccgggcatcaaccccagcttc gtgttcctgcagctctaccactctcctttctttggcgacgagtccaacaagccgatcctt ctgcctaacgagtccttcgagcggtcggtgcagctcctcgaccagatcccatcctacgac acgcacaagatcgcggtcctgtacgtgggagaaggccagagcagcagcgagctcgccatc ctgtccaacgagcacggctcgtaccggtacacagagttcctgacgggcctgggcaagctc atcgagctcaaggactgccagccggataaggtgtacctgggcggtctggacgtgtgtggg gaggacggccagttcacctactgctggcacgatgacatcatgcaggctgtcttccatatc gccaccctgatgcccaccaaggacgtggacaagcaccgctgtgacaagaagcgccatctg ggcaacgactttgtgtccattgtctataatgactccggcgaggacttcaaactgggcacc attaaaggtcagttcaacttcgtccacgtgatcatcacccccctggactacgagtgcaac ctggtgtccctgcagtgcaggaaggacatggagggcctcgtggacaccagcgtggccaag atcgtgtctgatcgcaacctgcccttcgtggcccgtcagatggctctgcacgccaacatg gcctcccaggtgcaccatagccgctccaaccccacggatatctacccgtccaagtggatc gccaggctccgtcacatcaagcggctgcgccaccgggtagggcagatccgtgaggaagcc cactactccaacccgagcctgccgctgacgcagacgcaccctccgggccacgccaaggcc ccagccccggccgagcccatgcccacgtacgagacgggccagcggaagcgcctcatctcc tctgtggatgacttcaccgagttcgtgtga

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