Prionailurus bengalensis (leopard cat): 122477714
Help
Entry
122477714 CDS
T07574
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
pbg
Prionailurus bengalensis (leopard cat)
Pathway
pbg01521
EGFR tyrosine kinase inhibitor resistance
pbg01522
Endocrine resistance
pbg04010
MAPK signaling pathway
pbg04012
ErbB signaling pathway
pbg04068
FoxO signaling pathway
pbg04270
Vascular smooth muscle contraction
pbg04650
Natural killer cell mediated cytotoxicity
pbg04720
Long-term potentiation
pbg04726
Serotonergic synapse
pbg04730
Long-term depression
pbg04810
Regulation of actin cytoskeleton
pbg04910
Insulin signaling pathway
pbg04914
Progesterone-mediated oocyte maturation
pbg04928
Parathyroid hormone synthesis, secretion and action
pbg05010
Alzheimer disease
pbg05022
Pathways of neurodegeneration - multiple diseases
pbg05034
Alcoholism
pbg05160
Hepatitis C
pbg05161
Hepatitis B
pbg05200
Pathways in cancer
pbg05205
Proteoglycans in cancer
pbg05208
Chemical carcinogenesis - reactive oxygen species
pbg05210
Colorectal cancer
pbg05211
Renal cell carcinoma
pbg05212
Pancreatic cancer
pbg05213
Endometrial cancer
pbg05214
Glioma
pbg05215
Prostate cancer
pbg05218
Melanoma
pbg05219
Bladder cancer
pbg05220
Chronic myeloid leukemia
pbg05221
Acute myeloid leukemia
pbg05223
Non-small cell lung cancer
pbg05224
Breast cancer
pbg05225
Hepatocellular carcinoma
pbg05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
pbg00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
122477714 (ARAF)
04012 ErbB signaling pathway
122477714 (ARAF)
04068 FoxO signaling pathway
122477714 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
122477714 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
122477714 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
122477714 (ARAF)
04914 Progesterone-mediated oocyte maturation
122477714 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
122477714 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
122477714 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
122477714 (ARAF)
04720 Long-term potentiation
122477714 (ARAF)
04730 Long-term depression
122477714 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
122477714 (ARAF)
05205 Proteoglycans in cancer
122477714 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
122477714 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
122477714 (ARAF)
05212 Pancreatic cancer
122477714 (ARAF)
05225 Hepatocellular carcinoma
122477714 (ARAF)
05226 Gastric cancer
122477714 (ARAF)
05214 Glioma
122477714 (ARAF)
05221 Acute myeloid leukemia
122477714 (ARAF)
05220 Chronic myeloid leukemia
122477714 (ARAF)
05218 Melanoma
122477714 (ARAF)
05211 Renal cell carcinoma
122477714 (ARAF)
05219 Bladder cancer
122477714 (ARAF)
05215 Prostate cancer
122477714 (ARAF)
05213 Endometrial cancer
122477714 (ARAF)
05224 Breast cancer
122477714 (ARAF)
05223 Non-small cell lung cancer
122477714 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
122477714 (ARAF)
05160 Hepatitis C
122477714 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
122477714 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
122477714 (ARAF)
09165 Substance dependence
05034 Alcoholism
122477714 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
122477714 (ARAF)
01522 Endocrine resistance
122477714 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pbg01001
]
122477714 (ARAF)
Enzymes [BR:
pbg01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
122477714 (ARAF)
Protein kinases [BR:
pbg01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
122477714 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
Pkinase_fungal
Kdo
TUG-UBL1
Motif
Other DBs
NCBI-GeneID:
122477714
NCBI-ProteinID:
XP_043426966
LinkDB
All DBs
Position
X:41852856..41864128
Genome browser
AA seq
615 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQVYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSSRTQHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSSLLQLTAQSFS
TDAAGSRGGGGDGAPRGSPSPSVPSGRKSPHSKSPSEQREQREQREQRERKSLADDKKKV
KNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAF
KNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVAR
QTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVL
WMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDL
SKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQA
DELPACLLSAARLVP
NT seq
1848 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtcttaatcaggattgctgtgtg
gtctaccggctgattgaggggcgaaagacagtcactgcctgggacacagccattgccccc
ctggatggagaggagctcatcgtagaggtccttgaagatgtgccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcactgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccgacaggtctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaggctccctcgaaccgccccctgaatgagccgcta
acccctcagggtcccagctcccgcacccagcaccgcgaccctgagcactttcccttcccc
gcccctgccaacgccccactccagcgcatccgctccacatccactcccaacgtgcacatg
gtcagcaccacggcccccatggactccagcctcctccagctcactgcccagagtttcagc
accgatgctgctggtagtagaggcggtggcggcgacggagccccccgggggagccccagc
cccagcgtgccctcggggaggaagtccccacattccaaatccccgtcggagcagcgggag
cagcgggagcagcgggagcagcgggagcggaagtccttggctgatgacaagaagaaagtg
aagaatctggggtaccgggactcgggctattactgggaggtgccgcccagcgaggtgcag
ctgctgaagaggatcgggacgggctcgtttggcaccgtgtttcgcgggcggtggcatggc
gacgtggccgtgaaggtgctcaaggtggctcaacccacagcggagcaggcgcaggccttc
aagaacgagatgcaggtgctcaggaagacacgccatgtcaacatcttgctattcatgggc
ttcatgacccggccgggatttgccatcatcacacagtggtgtgagggctccagcctgtac
caccacctacatgtggccgacacacgcttcgacatggtccagctcatcgacgtggcccgg
cagactgcccagggcatggactacctccatgccaagaacatcatccaccgagatctcaag
tctaacaacatcttcctacacgaggggctcacagtgaagatcggtgactttggcctggcc
acggtgaagacacggtggagcggggcccagcccttggaacagccctcgggctctgtgcta
tggatggcggctgaggtgatccgtatgcaggacccgaacccctacagcttccagtcggat
gtctacgcctacggggttgtgctctatgagctcatgaccggctcgctgccttacagccac
attggcagccgtgaccagattatcttcatggtgggccgtggctatctgtccccggacctc
agcaaaatctccagcaactgccccaaggccatgcggcgcctgctgtctgactgcctcaag
ttccagcgagaggaacgtcccctcttcccccagatcctggccacgattgagctgctgcag
cggtcactccccaagattgagcggagtgcctccgaaccctccttgcaccgcacccaggct
gatgagttgcctgcctgcctcctcagcgcggcccgccttgtgccttag
DBGET
integrated database retrieval system