Prionailurus bengalensis (leopard cat): 122486637
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Entry
122486637 CDS
T07574
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
pbg
Prionailurus bengalensis (leopard cat)
Pathway
pbg00310
Lysine degradation
pbg01100
Metabolic pathways
pbg05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
pbg00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
122486637 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
122486637 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
pbg03036
]
122486637 (DOT1L)
Enzymes [BR:
pbg01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
122486637 (DOT1L)
Chromosome and associated proteins [BR:
pbg03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
122486637 (DOT1L)
HMT complexes
Dot1-containing complex
122486637 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
122486637
NCBI-ProteinID:
XP_043441971
LinkDB
All DBs
Position
A2:1384969..1448752
Genome browser
AA seq
1692 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNTTTPTKVP
ESKAAVAADTPVDSGAEEEKAGTTAIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAA
NPERKPRKSQTALDLLHAPASSQTAAPSPQDAYRSPHSPFYQLPPCVQRHAPDRPLLAAT
PPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQEDNRELRSQSLQLL
KARCEELKLDWSTLSLENLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSAHLRGKGALGREPEADPGRLHLDLDCSRFSLPHFSSASPELSMNGHAASY
ELCGALSRPPSKQNTPQYLASPLDQEVVPCTPSHGSRPRLEKVSGLALPDYTRLSPAKLV
LRRHLSQDHAAGGKTAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPVALQM
TGERGSEKGLKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRST
PSPVPQTRESLSTLEKQMGANAHSAGSKSLAPAPAGFYAGSVAVSPAPLASGADPGTFDE
VPSAGGLFASVGSCGSTPQHPPLLPQPRGSGAASPAHPLCASPRLGGAAQGPLPDANKGD
LPPEAGFSDPEGEAKRRIVFTVSAGGGSTKQSPPSKPSPLPTGGRGDGSQGHGQDSRKRG
RRKRAAAGTPGLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPE
SLKSSPVPYQDSDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSTRIERKIATIS
LESRSPPKTLENGGGLAGRKPTPAGEPANSSKWKSTFSPISDLGLAKCADSPLQAGSALS
QNSLFAFRPPLEEPGSADAKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFSGGLAADLS
LHSFSDGASLSHKVPEAAGLGAPLSFPAPRGKDSAAEPGPFVNKRQLDGAGGPKGREAGE
PGPPACGPPDKALLAHGKPGKGRDREPDLKNGHNLFIAAANVPPGGLLSGPGLATAASSV
VSAAPSAQAHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFGSVPAAGLVHVSSAATR
LTNSHAMGSFPSGVAGGAVGGVFNHAVPSASAHPFGASFGSGAACRSATLSLTPLQAVAG
APPPPPPGQPALPAPPPPNAALPPAPALLPANSEPALLQNLASLPANQAFLPASSAASLQ
PANASLSIKLASLPHKAPRPSFTVHHQPLPGLALAQAAPVIPQASSTGPSAVWVSLGMPP
PYAARLAGVKPR
NT seq
5079 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtaggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcacgaaatcatcgagacc
atccggtgggtctgcgaagagatcccggacctcaagctcgctatggagaactacgtttta
atcgactacgacaccaaaagcttcgagagcatgcagaggctctgtgataagtacaaccgc
gccatcgacagcatccaccagctgtggaaggggaccactcagcccatgaaactgaacacc
cggccgtccaacgggctcctgcggcacatcctgcagcaggtgtataaccactcggtgacg
gaccccgagaagctcaacaactacgagcccttctccccggaggtgtacggggagacctcc
tttgacctggtcgcgcagatgatcgacgagatcaagatgactgaggacgacctgtttgtg
gacctgggcagtggagtgggccaggtcgtgctccaggtggccgcggccaccaactgcaaa
catcactacggcgtggagaaagccgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggcgacttcctctcggaggagtggagagagcggattgccaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcgaacatg
aaggaaggcggcagaattgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agcagaaacttgagcgacatcggcaccatcatgcgcgtcgtggagctctcgcccctgaag
ggctctgtgtcctggacggggaagccagtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggagcaggaggcg
gctcggcgccggcagcagcgagagagcaagagcaacacgaccactcccaccaaggtgccc
gagagcaaggctgccgtggccgcggacacccccgtggattccggtgccgaggaagagaag
gctgggacgaccgccatcaaaaagccgtccccctccaaagcccggaagaagaagctgaac
aagaaggggcggaaaatggccggcaggaagcgcgggcgccccaagaagatgagcgctgcc
aaccccgagcgcaagccccggaagagccaaactgcactggacctcctgcacgccccggcc
tcgtcgcagacggcggcgccctcgccacaggatgcgtacaggtcacctcatagccccttc
tatcagctacctccctgcgtgcagcggcacgcccccgaccggccgctgctggcagccacc
ccgcccgcactgcagaagctgctagaatccttcaagattcagtacctgcagttcttggcc
tacaccaagacggcccagtacaaggccagccttcagcagctgctggaccaggagaaggag
aagaacgcccggctgctgggggccgcacagcagctgttcggccactgccaggcccagaaa
gaggagatcaagaggctcttccagcagaaactggatgagctgggggtgaaggcgctgacc
tacaacgacctgattcaggcgcagaaggagatctcggcccataaccagcagctgagggag
cagacagagcagctgcaggaggacaacagggagctgaggagccagagcctgcagctgctc
aaggctcggtgtgaggagttgaaactggactggtccacgttgtcgctggagaacctgctg
aaggagaagcaggccctgaggagccagatctccgagaagcagaggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaagagcttctgcagctcaag
tcctgcgtgccgcccgacgacgccctgtcggcgcacctgcgcgggaagggcgccctgggc
cgagagccggaggcggaccccggccggctgcacctcgacctggactgctctaggttctcc
ctgccgcacttcagcagcgccagcccggaactctccatgaacggccacgcggccagctac
gagctctgcggtgcgctgagccggcccccgtccaagcagaacaccccccagtacctggcc
tccccgctggaccaggaggtggtgccctgcacccccagccacggcagccggccaaggctc
gagaaggtgtctggcctggccttgccggactacaccaggctgtccccggccaagctggtg
ctgaggcggcacctcagccaggaccacgcggccggcggcaagacggcggccggggagctg
cacccgcgagccgagcacgccaaggagaacggccttccgtaccagagcccgggcatcgcc
aacggcatcaagctgagccctcaggacccccggccctcatcccccgtggccttacagatg
acaggggagaggggcagcgagaagggtttgaaggagcgtgcctacgccagcagcggggag
gccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcccagcaagctgccc
gtcagcatccctctggccagcgtggtgctgcccagccgtgccgagaaagtgagaagcacc
cccagtcccgtgccgcagacccgagagtccttgtccacgcttgaaaagcagatgggcgct
aatgcacacagcgccggaagcaaaagtctcgccccagcccctgcaggcttctacgcgggc
tcggtggccgtcagcccagcccccctcgcttccggagcagatcccggcacctttgacgag
gtccccagcgcaggcggtctgtttgccagcgtggggtcctgtggctccaccccgcagcac
ccgcccctgctgccgcagccccgcggctctggcgcagcctcgcccgcccacccgctctgc
gccagcccccgcctgggcggcgccgcccagggtccgctccctgacgccaacaaaggggac
cttcctcccgaggccggcttctcggaccccgagggcgaagccaagcggaggatcgtcttc
accgtctcggccggcgggggcagcaccaagcagtcgcctcccagcaagcccagccctctg
cccacgggcggccgtggggacggcagccagggccacgggcaggacagccgcaagcggggc
agaaggaagcgggcggcggcagggacccccggcctgagctcaggcgtgtcgcccaagcgc
cgggccctgccatccgtggccggcctcttcacgcagtcttcagggtcccccctgaacctc
aactccatggttagcaacattaaccagcctttggaaatcacggccatttcgtcccctgag
agcctgaagagctcccctgtcccctaccaggacagcgaccagccgcccgtcctcaagaag
gagaagcccctgagccagaccaacggggcccactactccccactgacctcggacgaggag
cagggctccgaggacgagccgggcagcaccagaattgagagaaaaattgcgacaatctcc
ttagaaagcagatctcccccgaaaaccttggaaaacggtggtggcctggctgggaggaag
ccgacccctgccggcgagcccgccaacagcagcaagtggaagtctaccttttcgcccatc
tccgacctcggcctggccaagtgcgccgacagcccgctgcaggccggctccgccctgagc
cagaactccctgttcgctttccggccccccctggaggagcccggctcggccgacgccaag
ctggccgcccaccccaggaaaagctttcccggtgccctgtcgggggcaggcgggctgagc
ccaagcagcaaccctcccaacggcttcgccttcagcgggggcctggccgccgacctcagt
ttacacagcttcagtgatggtgcttctctctcccacaaggtccccgaggcggcaggcctg
ggcgcccccctgagctttcccgccccccggggcaaggacagcgctgcagagcctgggccc
tttgtgaacaagaggcagctggacggcgcgggcggccccaagggcagggaggcaggcgag
ccgggccccccggcgtgcgggcccccggacaaggccttgctggcgcacggcaagccgggc
aagggccgggaccgtgagcccgacctgaagaacggccacaacctcttcattgcggccgcc
aacgtgccccccgggggcctcctcagtggcccgggcctcgccacggcggcgtcctcggtg
gtcagcgcggccccctccgcccaggcgcaccgccccttcctgggcacatttgcccccggc
ccgcagttcgccctgggccccatgtcgctgcaggccaacctgggctcgtctgtgctgcag
tccctgtttggctccgtgccggccgccggcctggtgcacgtctcgtccgccgcaaccaga
ctgaccaactcgcacgccatgggcagctttccctccggggtggcaggcggcgcagttgga
ggtgtctttaaccacgcggtgccttccgcctccgctcatccgtttggagccagtttcggc
agcggggctgcgtgtcgcagcgccacgctgagcttaaccccgctgcaggcggtggccggc
gccccgcccccgcccccaccggggcagcctgccctccccgcgccccctccccctaacgcc
gccttgcctcccgcccccgcgctgctcccggctaactctgagcccgcgcttctgcagaac
ctcgcgtccctcccggctaaccaggctttcttacccgcctcctctgccgcctctctgcag
cctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggccccccgcccc
tccttcacggtgcaccaccagcccctgcccgggctggccctggcccaggccgcgcccgtg
atcccacaggccagctccacggggccgtccgccgtgtgggtttcccttggcatgccgcct
ccgtatgccgcgcgccttgcgggggttaagccaagataa
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