Prionailurus bengalensis (leopard cat): 122491215
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Entry
122491215 CDS
T07574
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
pbg
Prionailurus bengalensis (leopard cat)
Pathway
pbg00230
Purine metabolism
pbg00670
One carbon pool by folate
pbg01100
Metabolic pathways
pbg01523
Antifolate resistance
Module
pbg_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
pbg00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
122491215 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
122491215 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
122491215 (GART)
Enzymes [BR:
pbg01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
122491215 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
122491215 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
122491215 (GART)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_2
ATP-grasp_4
CPSase_L_D2
ATP-grasp_3
Dala_Dala_lig_C
CbiJ
RimK
ATP-grasp_5
Motif
Other DBs
NCBI-GeneID:
122491215
NCBI-ProteinID:
XP_043449626
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All DBs
Position
C2:11780795..11809874
Genome browser
AA seq
1009 aa
AA seq
DB search
MAARVLVIGGGGREHTLAWKLAQSNRVKHVLVAPGNAGTACLEKISNTAISISDHTALAQ
FCKDENIEFVVVGPEAPLAAGIVGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWRAFTRPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSTEEACRAVQEIMQEKAY
GAAGETIVIEELLEGEEVSCLCFTDGRTVVPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLLLKIKNTVLQRTVDGMQQEGMPYTGVLYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTFDGLLHTSLPVWLENRTALTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKDGKVVTSGGRVLSVTAIQENLTSALEEAKKGLAAIKFEGAIYRKD
IGSRAIAYLQQPRGLTYKESGVDIAAGNMLVKKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFKDPLLACGTDGVGTKLKIAQQCNRHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLDTTEAVVAGIARACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDAVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKFGVDLDAQTWRIPRIFSWLQQEG
HLSEEEMARTFNCGVGAVLVVSKDRTEQILRDIKQHSEEAWVIGKVVACPEGSPRVKVKH
LIETMQANGSVLENGTLKNHFSVQPKKARVAVLISGTGSNLQALIDNTREPSSCAHIVVV
ISNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLEAGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVTTLSERVKLAEHRLFPAALHLVASGTVQLGENGKIRWVTE
NT seq
3030 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgcgtacttgtaattggcggtggcggaagggaacatacactggcctggaaa
cttgcacagtctaatcgtgtcaaacatgtgttggttgccccgggcaatgcaggcactgcc
tgcttggaaaagatttcaaatactgccatctcgataagtgatcacactgcccttgctcag
ttctgcaaagatgagaacattgaattcgtagttgttggaccagaggcacctctggctgct
ggaattgttgggaacctgacctctgcaggagtgcgatgctttggtcccacagcagaagca
gctcagttagagtccagcaagagatttgccaaagagtttatggaccgacacggaatccca
accgcacggtggagagctttcaccagacctgaggaggcctgcagcttcattatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctgggaaaggggtgattgtt
gcaaagagcacagaagaagcctgcagggctgtacaggagatcatgcaggagaaagcttat
ggagcagctggagaaacaattgtcattgaagaacttcttgagggagaagaggtttcttgt
ctgtgcttcactgatggcaggaccgtggtccccatgcccccagcacaagaccataaacga
ttgctggagggtgatcacggccccaacacagggggaatgggagcctattgtcctgcacct
caggtttcgaaggatttgctgctgaaaataaaaaatacagttcttcagaggacagtggat
ggcatgcagcaggagggtatgccatacacaggtgtcctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagtttaattgccgtttcggtgatccagagtgccaagta
atcctcccgctgcttaaaagtgatctttatgaagtgattcagtctacctttgatggcctg
ctccacacatctctgcctgtctggctggaaaaccgcaccgccctaactgtcgtgatggca
agtaagggctacccaggagattacaccaagggtgtggagataacaggctttcctgaggct
caagctttaggactggaggtgttccatgcaggcactgccctgaaagatggcaaagtggtg
actagtgggggtagagtcctttcagtaacagccatccaggaaaatctcacttcagccctt
gaagaagccaagaaaggactagctgctataaaatttgagggagccatttacaggaaggac
attggctctcgtgccatagcttacctccaacagcccaggggcctgacttacaaggaatct
ggggtagacattgcagctggaaatatgctggtcaagaaaattaaacctttagcaaaagct
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcctgtggaacagatggtgtggggactaaactg
aagattgcccagcagtgtaatagacatgataccattggccaagatttggttgcaatgtgt
gtaaatgatattctggcccaaggggcagagcccctcttcttccttgattacttttcctgt
ggaaaacttgacctcgatacaactgaagctgttgttgctggaattgccagagcctgtggg
aaagctggatgtgctctccttggaggtgaaactgcagaaatgcctgacatgtatcctccc
ggagagtatgacctggccggttttgccgtcggtgccatggagcgggatcagaaactccct
cacctggaaagaatcaccgaaggggatgccgttattggaatagcttcatctggtcttcac
agcaatggatttagccttgtgaggaaaattgtagcaaaatcttccctccagtactcctct
ccagcacctgatggctgtggtgaccagaccttaggggacttacttctgactccaacgaga
atctacagccattcgctattacctgtcctacgttcaggacatgtcaaggcctttgcccat
attactggtggaggattgctagaaaacatccccagagtccttcctgagaaatttggagtg
gatttagatgcccagacctggaggatccccaggatcttctcgtggttacagcaagaagga
cacctctctgaggaagagatggccagaacatttaactgtggggttggggctgtcctcgtg
gtgtcaaaggataggacagagcagattctgagggatatcaagcagcacagcgaagaagcc
tgggtgattggcaaggtggttgcgtgtcctgaaggttctcctcgtgtgaaagtcaagcat
ctgattgaaaccatgcaagcaaatggatcagtattggagaatggcactctgaaaaatcat
ttctctgtccaaccaaaaaaggcaagagtggctgtcttaatatctggaacaggatcaaac
ctccaagccctcatagacaatactagggagccaagtagctgtgcacacatcgttgttgtt
atctccaacaaagctgcagtggctggcttagataaagcagaaagagccggaattcccacc
agagtaatcaatcataaattatataaaagtcgtgtagaatttgacactgcaattgaccaa
gtccttgaagagttctccacagacatagtctgtcttgcaggattcatgagaattttatct
ggcccctttgtcagaaaatggaatgggaaaatgctcaacatccatccatccttgctcccg
tcttttaagggttcaaatgcacatgagcaagtcctagaagccggggtcacagtcactggg
tgtactgtgcactttgtagctgaagatgtagatgctggacagattatcttacaagaagct
gttccagtgaagaggggcgacaccgttacaactctgtctgaaagagtgaaattagcagag
cacagactatttcccgcagccctccacctggtagccagtggaactgtacagcttggagaa
aatggcaagattcgttgggtcacagagtag
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