Petaurus breviceps papuanus (sugar glider): 138169106
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Entry
138169106 CDS
T10505
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
pbrv Petaurus breviceps papuanus (sugar glider)
Pathway
pbrv01521
EGFR tyrosine kinase inhibitor resistance
pbrv01522
Endocrine resistance
pbrv04010
MAPK signaling pathway
pbrv04012
ErbB signaling pathway
pbrv04014
Ras signaling pathway
pbrv04015
Rap1 signaling pathway
pbrv04022
cGMP-PKG signaling pathway
pbrv04024
cAMP signaling pathway
pbrv04062
Chemokine signaling pathway
pbrv04066
HIF-1 signaling pathway
pbrv04068
FoxO signaling pathway
pbrv04071
Sphingolipid signaling pathway
pbrv04072
Phospholipase D signaling pathway
pbrv04114
Oocyte meiosis
pbrv04140
Autophagy - animal
pbrv04148
Efferocytosis
pbrv04150
mTOR signaling pathway
pbrv04151
PI3K-Akt signaling pathway
pbrv04210
Apoptosis
pbrv04218
Cellular senescence
pbrv04270
Vascular smooth muscle contraction
pbrv04370
VEGF signaling pathway
pbrv04371
Apelin signaling pathway
pbrv04380
Osteoclast differentiation
pbrv04510
Focal adhesion
pbrv04540
Gap junction
pbrv04550
Signaling pathways regulating pluripotency of stem cells
pbrv04613
Neutrophil extracellular trap formation
pbrv04620
Toll-like receptor signaling pathway
pbrv04650
Natural killer cell mediated cytotoxicity
pbrv04660
T cell receptor signaling pathway
pbrv04662
B cell receptor signaling pathway
pbrv04664
Fc epsilon RI signaling pathway
pbrv04666
Fc gamma R-mediated phagocytosis
pbrv04668
TNF signaling pathway
pbrv04720
Long-term potentiation
pbrv04722
Neurotrophin signaling pathway
pbrv04725
Cholinergic synapse
pbrv04726
Serotonergic synapse
pbrv04730
Long-term depression
pbrv04810
Regulation of actin cytoskeleton
pbrv04910
Insulin signaling pathway
pbrv04912
GnRH signaling pathway
pbrv04914
Progesterone-mediated oocyte maturation
pbrv04915
Estrogen signaling pathway
pbrv04916
Melanogenesis
pbrv04917
Prolactin signaling pathway
pbrv04919
Thyroid hormone signaling pathway
pbrv04921
Oxytocin signaling pathway
pbrv04926
Relaxin signaling pathway
pbrv04928
Parathyroid hormone synthesis, secretion and action
pbrv04929
GnRH secretion
pbrv04934
Cushing syndrome
pbrv04935
Growth hormone synthesis, secretion and action
pbrv05010
Alzheimer disease
pbrv05022
Pathways of neurodegeneration - multiple diseases
pbrv05034
Alcoholism
pbrv05132
Salmonella infection
pbrv05135
Yersinia infection
pbrv05160
Hepatitis C
pbrv05161
Hepatitis B
pbrv05163
Human cytomegalovirus infection
pbrv05164
Influenza A
pbrv05165
Human papillomavirus infection
pbrv05166
Human T-cell leukemia virus 1 infection
pbrv05167
Kaposi sarcoma-associated herpesvirus infection
pbrv05170
Human immunodeficiency virus 1 infection
pbrv05200
Pathways in cancer
pbrv05205
Proteoglycans in cancer
pbrv05206
MicroRNAs in cancer
pbrv05207
Chemical carcinogenesis - receptor activation
pbrv05208
Chemical carcinogenesis - reactive oxygen species
pbrv05210
Colorectal cancer
pbrv05211
Renal cell carcinoma
pbrv05212
Pancreatic cancer
pbrv05213
Endometrial cancer
pbrv05214
Glioma
pbrv05215
Prostate cancer
pbrv05216
Thyroid cancer
pbrv05218
Melanoma
pbrv05219
Bladder cancer
pbrv05220
Chronic myeloid leukemia
pbrv05221
Acute myeloid leukemia
pbrv05223
Non-small cell lung cancer
pbrv05224
Breast cancer
pbrv05225
Hepatocellular carcinoma
pbrv05226
Gastric cancer
pbrv05230
Central carbon metabolism in cancer
pbrv05231
Choline metabolism in cancer
pbrv05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
pbrv00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
138169106 (MAP2K1)
04012 ErbB signaling pathway
138169106 (MAP2K1)
04014 Ras signaling pathway
138169106 (MAP2K1)
04015 Rap1 signaling pathway
138169106 (MAP2K1)
04370 VEGF signaling pathway
138169106 (MAP2K1)
04371 Apelin signaling pathway
138169106 (MAP2K1)
04668 TNF signaling pathway
138169106 (MAP2K1)
04066 HIF-1 signaling pathway
138169106 (MAP2K1)
04068 FoxO signaling pathway
138169106 (MAP2K1)
04072 Phospholipase D signaling pathway
138169106 (MAP2K1)
04071 Sphingolipid signaling pathway
138169106 (MAP2K1)
04024 cAMP signaling pathway
138169106 (MAP2K1)
04022 cGMP-PKG signaling pathway
138169106 (MAP2K1)
04151 PI3K-Akt signaling pathway
138169106 (MAP2K1)
04150 mTOR signaling pathway
138169106 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
138169106 (MAP2K1)
04148 Efferocytosis
138169106 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
138169106 (MAP2K1)
04210 Apoptosis
138169106 (MAP2K1)
04218 Cellular senescence
138169106 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
138169106 (MAP2K1)
04540 Gap junction
138169106 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
138169106 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
138169106 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
138169106 (MAP2K1)
04620 Toll-like receptor signaling pathway
138169106 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
138169106 (MAP2K1)
04660 T cell receptor signaling pathway
138169106 (MAP2K1)
04662 B cell receptor signaling pathway
138169106 (MAP2K1)
04664 Fc epsilon RI signaling pathway
138169106 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
138169106 (MAP2K1)
04062 Chemokine signaling pathway
138169106 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
138169106 (MAP2K1)
04929 GnRH secretion
138169106 (MAP2K1)
04912 GnRH signaling pathway
138169106 (MAP2K1)
04915 Estrogen signaling pathway
138169106 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
138169106 (MAP2K1)
04917 Prolactin signaling pathway
138169106 (MAP2K1)
04921 Oxytocin signaling pathway
138169106 (MAP2K1)
04926 Relaxin signaling pathway
138169106 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
138169106 (MAP2K1)
04919 Thyroid hormone signaling pathway
138169106 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
138169106 (MAP2K1)
04916 Melanogenesis
138169106 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
138169106 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
138169106 (MAP2K1)
04726 Serotonergic synapse
138169106 (MAP2K1)
04720 Long-term potentiation
138169106 (MAP2K1)
04730 Long-term depression
138169106 (MAP2K1)
04722 Neurotrophin signaling pathway
138169106 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
138169106 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
138169106 (MAP2K1)
05206 MicroRNAs in cancer
138169106 (MAP2K1)
05205 Proteoglycans in cancer
138169106 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
138169106 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
138169106 (MAP2K1)
05230 Central carbon metabolism in cancer
138169106 (MAP2K1)
05231 Choline metabolism in cancer
138169106 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
138169106 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
138169106 (MAP2K1)
05212 Pancreatic cancer
138169106 (MAP2K1)
05225 Hepatocellular carcinoma
138169106 (MAP2K1)
05226 Gastric cancer
138169106 (MAP2K1)
05214 Glioma
138169106 (MAP2K1)
05216 Thyroid cancer
138169106 (MAP2K1)
05221 Acute myeloid leukemia
138169106 (MAP2K1)
05220 Chronic myeloid leukemia
138169106 (MAP2K1)
05218 Melanoma
138169106 (MAP2K1)
05211 Renal cell carcinoma
138169106 (MAP2K1)
05219 Bladder cancer
138169106 (MAP2K1)
05215 Prostate cancer
138169106 (MAP2K1)
05213 Endometrial cancer
138169106 (MAP2K1)
05224 Breast cancer
138169106 (MAP2K1)
05223 Non-small cell lung cancer
138169106 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
138169106 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
138169106 (MAP2K1)
05161 Hepatitis B
138169106 (MAP2K1)
05160 Hepatitis C
138169106 (MAP2K1)
05164 Influenza A
138169106 (MAP2K1)
05163 Human cytomegalovirus infection
138169106 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
138169106 (MAP2K1)
05165 Human papillomavirus infection
138169106 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
138169106 (MAP2K1)
05135 Yersinia infection
138169106 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
138169106 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
138169106 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
138169106 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
138169106 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
138169106 (MAP2K1)
01522 Endocrine resistance
138169106 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pbrv01001
]
138169106 (MAP2K1)
Enzymes [BR:
pbrv01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
138169106 (MAP2K1)
Protein kinases [BR:
pbrv01001
]
Serine/threonine kinases: STE group
STE7 family
138169106 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
Motif
Other DBs
NCBI-GeneID:
138169106
NCBI-ProteinID:
XP_068954347
LinkDB
All DBs
Position
Unknown
AA seq
393 aa
AA seq
DB search
MPKKKPMPIQLNPTPDGSTINGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCPMEGDVPETSPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHTF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgatgcccattcaactgaacccgaccccggatggctccacgatt
aacgggaccagctcggccgagactaaccttgaggccctgcagaagaagctggaagaatta
gaactggatgaacagcagcgaaagcgtctggaggcttttcttacccagaaacagaaagtg
ggcgagctgaaggatgacgactttgagaagatcagcgaactgggtgctgggaatggtggt
gtggtgttcaaagtttcccacaaaccctctggcctaatcatggcaaggaagctaattcac
ctggagatcaagccagcaattcggaaccagattatacgggagctacaagtcctgcatgaa
tgcaactctccatatattgtaggattttatggggccttttacagtgatggggagatcagt
atctgcatggagcacatggatggaggatctttggaccaggttcttaagaaggctggaaga
attcctgagcagatcttggggaaagttagcattgctgtaataaagggccttacatacctg
agggagaagcataagataatgcacagagatgtcaagccatccaacatcttggtgaactca
cgtggggaaatcaagctttgtgactttggcgtcagtgggcagctgattgattccatggct
aattctttcgtgggcacaaggtcctatatgtcgccagaaagactccagggaactcactac
tcagtgcagtcggacatctggagcatggggctttctttggtggagatggcaattggacga
tatcccattccaccaccagattccaaggagctggaattgatgtttggctgtccaatggag
ggagatgttcctgagacgtcaccaaggccaagaactcctgggaggcctctcagctcttat
ggaatggatagccgaccacctatggcaatttttgagctgctggattacatagtcaatgag
cctcctcccaagttgcccagtggagtctttagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaacccagcagagagagccgatttgaagcaacttatggttcatactttt
atcaagaggtctgatgccgaggaagttgattttgcaggctggctctgctccaccataggc
cttaaccagcctagcacaccaactcatgctgctggtgtctaa
DBGET
integrated database retrieval system