Pieris brassicae (large cabbage white): 123712244 Help Entry 123712244         CDS       T08632                                  Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism pbx  Pieris brassicae (large cabbage white) Brite KEGG Orthology (KO) [BR:pbx00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:pbx04121]     123712244 Enzymes [BR:pbx01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      123712244 Ubiquitin system [BR:pbx04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     123712244 SSDB OrthologParalogGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4_TPR UBR4_Ub UBR4 zf-UBR_1 zf-UBR Ivy Flu_PB2_1st Motif Other DBs NCBI-GeneID:  123712244 NCBI-ProteinID:  XP_045521245 LinkDB All DBs Position 1:complement(11864026..11898797) Genome browser AA seq 5218 aa AA seqDB search MAAAGGSIEWSTNVKPILTALYGPFFDKNDAVEIIQAIIKSENEFQKHEEAYDLFYTCFA CLSAHFISINANNIPPDQLSTAQDAFRIILQQILKKLSEAGQSQEDTSNTLSPNVSVKQL LLPIVALCGIDSNGYPPSDLVILLALLKTAKLPPHGNTNENQTTKSSISSPITSLASNTS TSEKQPPTNAQRRSDALLERLTMPLRSQVSNVMPSVPSAIGVMSPASKDSIESAKEGNAQ LSSIDIKKWVASTCASLLMELRAGSTILAICSSLPCLQRYLNRWQTAKESDSAPTFHSDA ALLYFLVNEVEVCRLALSLPCLEPFSPERIVTLSDVSASWLLCATAQATLHQKDEESEAQ TATIVETALNLYSTVGDIFKQSTRAGGYVYQNHLMIGAWVLVCGLHHALGGAPGPTPPGK SPAKTPLRPYNLTKMQQSLGVVWVALGGRCLSWLSALLADARLEALSSGSDSASGPASLH ISTLHSAHQRELRLALAAPLHQLLVTLGVVCYRKATNLKRAVVPKDQDAEADRSEGAAFF RDMRLCSEDSETDDDDSEPLFGLWFESTLVAPDADDDGLTRLGAAEVTDAAPDSTERGIV PDKAEPYSYISLATDVFTLLTDEMIGGGFERLGRYALQLHEAHHALLAALARDLDRESAR TDTGTISPCFGARLGALYSSFSSALVRYLHTLSGSPAFAALRPSLQQQLASAERPNTVPL QVGPRVVKLLGGMVLSKPASERENSILVMWHNLINTLQEYALQPLPSQDHDYEDLNVEHA QLMVYLFHSLTLMQKKSVLLSTANAIIKVVETLGINERQRATNLAPHRLTLSTRLMLLLE YLMKHLYDAPQTLLQQIEWNLVVATGLARPSAETTLGEVGTGSDAGPPKTRIYCEVPFVE QTYRRLSQDETSMRPKFYALTDTKVNNQENPKFDGLACNFVLGTPHKLKYPVLVDALLAL LNCACVCDGRGDRTAVAARAAAHYCFQTAWRLVTSMPPATPHVDKLQAGTAADLPSPLPL YALVWAPRADAKKAFNPWLKDALVKQGMYTQYAENLLAGVSSSCDNIKYSAWLASETIKH LKENLRDGLPALLDVISCDAALMRLNVCLAETSSAAEAHPFVPHLLRLLETVLACCRSSA SLEAGGSAGAATEVLLSVCGGGPSAGAASPPRLGPALKALLPSDVAALLDSRSADPVSLA LFYSRSERLLRVAPRTRFTTAVVSQASSVAPSEGAVLELVSAHCELMSDRPAYGVGPSLT MLARSAAKLLEVGAAEIADSLELTRRTLALIVPALTDGRLEFLAEPLTATLNSIVPQAVK AEEIIHEHILRTTYPALCDYDASAEGMLVHIVKYWEKILDRQAGRAAYEAVFVEGDGEFV LGRILLSAPNTSNPFTDRVVKLFIKIFAGCETEDVSQSLCVGVCKFIGVADRQSLFDLLG HICIYGPSLATVGTANGSPTETELPTPTCSAPEGHPASLALRNAIRCVLFRTDGDAAPRP DARNDRDLPVFDNPVAATPAPGAQSETNAQQSGNSETCSWSDCSKDSAGATGAGVGESRA EASSPVGEGTHAALLTALCKHVVLHCEEEASERMLVTLIEVSGEGCPPPLLREMCRLADS HSGTLHELLFPAALAWLSSCVESLSSPEVLEKLEEGTIDNDKTSPQIESACTLLSYLGDA LHAIGAPPSHAWRSVSPTWESPSDLGFDLDYADEQQDDDDTSADDSDEDAVLTNKLCTFT ITQREFMNQHWYHCHTCKMVDGVGVCTVCARVCHRGHDISYAKFGNFFCDCGAKPDFSCQ ALVKREKSSGGGRTAEEAPPAPSLRRRPSSPTPAALLAPPRRPVLAHNIQGCRSFLASYG KWEWCLERVRTLLCALAGPVRAACERTAAVGAHGRAQRALAQLHLGEKKFSHTDSLMLPT LGSQEGAFENVRMSYTGENGQTIRQLISAHKLRRVAMCCLASPQGRRQHLAVSHEKGKIT VLQLSALLKQADSSKHRLTLTRLSSAPIPFTVLSLSGNAANEDLLAVCGLKECHVLTFNS GGAVADHLVLTTDLEANNYIIKAIWLPGSQTQLALVTSNFVKIFDLSKDLDSPSHYFLVP SGKVRDVTFVNQEGVMNMLCMSSAGHIYWQPLSEESRATLGTFYVTNTLEVLHPEIQDVA GLVGGGGVSIYYSHTLKMLFFSYAQGKSFLAPLNSVEESVKGTAMITVYGGGGGPKEGGR GKGGAQSLLQWAEVPGHPGLLTALMQASNNPVVLMLTPSGIHVQEIKVVPAKAKITDMVA VRHWCGPGEQKSTLILLCEDGSLRMYAADPARTGFWLSGAVQPVHAPRRRARPARPSHAH AVPRKQHQPTPKTSDGAPQFPIDFFEHCHEMRDAEFGGNDLLQVYNTAQIKHRLNTTGLY VVSTKMSGFTMEVTNSDPNSVVCGIRVLLGSQDVARTPTYIEIYGRAVPTMVVRNRWFDV PLSREESLQSDKKLCIVFGPSQDPDGVTMVDSVKIYGKNKEQFGWPEENEDPAACPSSGR VPQETEGAAGSADGPGAVERLACSALEALELSAGTAVRPAVAAGADAAADAAEGLLCVPA SPALHARAQCLLRAVYQGDYHQRKDRAVLRYVCASLRELRDATDARNVDPEAYFRLVLLA RSVAVARPHNLVRFTAPTPEKPADGDWSALWKGDGSGDEPHACVLLASVLWKLAACKSQA RGPPGILSYGLRHAEHTLHALADIIHAFQLNSDPECVEFGNQIYLSLLLAEDQNISFGAK AALVRVLRPRVKRRRVYIPSPPNTPGAGSSTNAARASGSASEVAASEPELGARREPRYVD VDDSLEPMVLLAPDGGLEALLDIPADADDETMVELAIALSLQEQEQPRRQQPHTPTAPPP PAPGFSDANASPNGSDDEGSTAATDGSTLRTSPAEAAGSAGEESGGSGADSIGGVSGRSS VYAGPSTSSSQPVASTSRGLEAESETRKLHALRLSLLSAALDALPTLRNLPGVRAIPFVQ VVLMLAGDLDSSVEGDRALLDLLLEVLIGELDIQSEEPSGEDRDARRDFQLAIARLETLV SEPESADESVPPIYERTNRRELQLVIMRLLSVLMSRWKTCGSREHAPSASCAAHVSRLAA AAFVRAGAPGHCYGVLAALLPYWRQKNNSNAAASTPTRQLLKPQPPQPLPDMQPFFVKEY VKSHVLDVFDNYPQLLMEMAVRLPYQIHKHCDPSHFDSRWRTLLCEYMMNPQTPLRKQVR KLLLLLCDTRERYRQIRDVHALDTHLNAARALLATDPAYDKLVRLMEHLKACVEIVTPRT GNWQHACRSERRETLPWLLGAARRLHPHVAPTVLQLLQAALCPPGAQPAHAAQPNQAGAK DAKAQPEWPKRERSADSDGYVSDASKFQEQRVPDLVAQIHKQVSQEELKLFVKAFLLETN STAVRWQAHALLLAIYNNSSPNKQASLVTLLWSLWPTLPQYGRKAAQFVDLLGYFTLKTS KVDGSEYIGSAVDLLRNQNRLLTSHGNSALYASLGAYVELEGYYLESEPCLVCNNPEVPM ATIKLPTIKIDSKFTTTTQIVKLVSSHTISRISLRVGDIKRSKMVRGINFYYNNRTVQAV QELKNKPGMWHKAKRVQLQSGQTEVRVDFPLPIVACNLMMEYADFYENQQATGESLQCPR CSQSVPANPGVCANCGENVFQCHKCRAINYDEKDPFLCHACGFCKYAKFDYTLIARPCCV VDSIENDEERKKTVQTIGTLLDKADRVYRQLIANKPHLESLVHKISEHRVDGRPDENSNT ATATLGGGQVNRVIQALAHKYCVESKGHFEDLSKIIQKVLACRKELVAYDKAQSERQNGE ASPAYSVLAQNYDGDLAKESGGSCYGCSLCTAEHCLTLLRALASQPDKRAALCGAGLVHE LVHHNLHRGTPQSQEEVRALICLVTRDNLAATERLCTLLTQRITLSLVGHAASQDHNNSV RPLVLLLGSLVKVQDSIECWEVRLRCVVKLWVWCCPKVSEVAGIPPAAHYILKDEALADM PGINTCSPNSHQFALQQVALPCLRYMQELMAPLAASPSPAPSALSAAASATDDRVEEVKE GDEPPNRTGDLVVDLAAWLAGRVSQKEWRSLAAPEASPPADCELPSRDLRLARECVGRWR RRVLLGRGMRRVSLSDGSWLRPVMFDPSSRIARDTACRVVASLCDSYERTKAVLILLTSF LPEVGAAGEASEQFLQLYQRLAAKSPWKQFLALRGVLQQIADLMTDEIEQLHRLEETTLT SDLAQGYALQRLTELLAMFLEEPGARRAYKGRLVGAVLGGYLSLRRLVVQRTRLTDDTQE KLLELLEEMTTGTEAETAEFMAVCIETVQKYPLHDYRTPVFIFERLCSIIYPEENDVGEF FLTLEKDPQQEDFLQGRMLGNPYSSGEPGMGPLMRDVKNKICTDCELVALLEDDNGMELL VCNKIMSLDLPVKDVYKKVWCTSGESLDAMRVVYRMRGLLGDATEEFVETLSQTNAEAVD DEQTYRMANVLADCGGLEAMLRRLAAIQRVGGARALVSTLLRLLSLCVRVRRCVRVLTST DTRALPVLLHALTLAAAEEKDMPRAELVHQLLEIMERILTVAASESLESFLQFSLTFGGP EHVQALLNCTELTAIRNNSVSLGHLMRVLAALVYGNDLKMAMLVEHFKPALEFERLDAEQ WGEREFRIELFCALCANVERNSVGGTLKDYLISLGVVRDALDYIVRHAPCVKPTLVCTDS DELKEFISRPALKFILRFLTGLASDHEPTQMLVCEKAIPIVHRLEQVSSGEHVGSLAENL LEALRSQPQCADRVRQVREFTRQEKKRLAMAVRERQLGALGMRSNERGQVTAQCSLTQQV ADLAEEAGAVCCICREGYKYQPTKVLGVYTYTKRCPVEEAEARARKTLGFTTVSHYNIVH VECHMAAVRLQRARDEWESAALQNASTRCNGLLPLWGPNVPESAFASCLARHTTYLQECT GHRDIGYQCTVHDLKLLAWRFARGRTFHDDTGGGGPLSNMQLLPALLHMALYVMNTTRMA AREANAVDEFLSWTPVKRLESAHEAEGALYYATLALLVCPPAEWRRNRVEVLRRLLITGQ ARSVSGGVQLHALTPEWRVPRPWADLKAFAVFAALVDQLYGVMFKNVSAATAEQWPVKLA EYIRVSDEANAKAAERIVATLTEELLPCTSFAEFCDAAGLLEDVPDPDAFLSTLFDEL NT seq 15657 nt NT seq  +upstreamnt  +downstreamnt atggccgccgctggtggatcaatagaatggtctaccaatgtgaaaccaattttaacagca ctttatggaccctttttcgataaaaacgatgcagtagaaataatacaagctattataaaa agtgaaaatgaatttcagaagcatgaagaagcatacgacttgttttacacatgttttgct tgcctctcagctcattttatcagcattaatgctaataacatacctccagatcagttaagc acagctcaagatgcttttcgcattatccttcaacaaatactcaagaaattgtctgaagct gggcagagccaggaagatacttctaataccctgagccccaatgtgtctgtcaagcagctg ctattgccaattgtggccttgtgtggtattgacagcaatggttatcccccttcggatctt gttattttgcttgcacttctaaagactgctaagctaccacctcatggaaacacaaatgaa aatcaaacaacaaagtcttcaatatcaagccccataacatctctcgcatcaaacacgtct acatcagagaagcaaccgccaacaaatgctcaaagacgatctgatgcactgctagaacgg ctgaccatgccacttcgcagtcaagtatcaaatgtaatgccttcggttccatctgccatt ggagtcatgtcaccggcaagcaaagacagtatcgagagtgctaaggaaggaaatgctcaa ctgtcttccattgatataaaaaagtgggtggcatccacgtgcgcgtcgcttctgatggag ctgcgagcgggctccacaatattggctatctgttcatccctgccttgcctccagcgatac ttgaaccgctggcaaactgccaaggaatccgattcggccccgacatttcattcggatgcc gcactgctgtacttcctggtgaacgaggtggaggtgtgtcgcctagcgctgtccctgcct tgcctggagcccttcagcccggagcgaatcgtcactctcagtgacgtcagcgcctcttgg ctcctctgcgctaccgcacaggccaccctccaccaaaaggacgaagagagtgaagcgcag acggcgacgatcgtggagaccgcgctcaacctctacagcaccgtgggagacatcttcaag cagtccacgcgcgccggaggatacgtgtaccaaaaccacttgatgatcggggcgtgggtg ctcgtctgcggtctgcatcacgcgctaggaggcgcgccgggacccaccccgccgggcaag agtcccgccaaaacgcccctcagaccctacaatttgaccaaaatgcagcagagcctgggc gtggtgtgggtggcgctgggcggacgctgcctgtcgtggctcagcgccctgctggccgac gctcgcctcgaggcgctcagctcgggctcggactccgcgagcggcccggcctcgcttcac atctcgactcttcactcggcgcaccagagggagctgaggctggccctcgccgctcctctg caccagttgttggtgaccctcggcgtagtgtgctaccgcaaggcgacgaacctcaagcgc gccgtggtgccgaaggaccaggacgccgaagccgaccgctccgagggcgccgccttcttc cgggacatgcgcctgtgctcggaggactccgagaccgacgacgatgacagcgaacctctg ttcggcctctggttcgagtcgacgctggtggcgcccgacgccgacgacgacgggctgacc cgcctcggcgccgccgaagtcactgacgcggcgcccgactcgaccgagcggggaatcgtg cccgacaaggccgaaccttactcgtacatatcgctcgcgaccgatgtgttcaccctcctg accgacgagatgatcggcggcggcttcgagcgcctcggtcgctacgctctccagctgcac gaggcccaccacgccctgttggcagcgctggctcgagacctggacagggagagcgccagg accgacacgggaacgatttcgccgtgtttcggcgcccgtctgggcgctctctactcgtcg ttcagttcggcgctggtgcgatatctccacacgctgagcggctccccggccttcgccgct ttgaggccttcgctgcagcagcaactcgcgtccgcggagcgacccaacaccgttccttta caggtcgggccgcgcgtggtgaagctgctcggcggcatggtgctgagcaagccggcttcg gagagagagaacagtatcctggtgatgtggcacaacctcatcaataccctgcaagagtac gccttgcagccgctgccctcgcaggaccacgactacgaagatctcaacgtcgaacacgct cagcttatggtgtacttgtttcactcgttgacgctgatgcagaagaagtccgttctgctc tccaccgccaacgccatcattaaggtggtggaaacgctgggcataaacgaaagacagcgc gcgacgaacctggctccgcatcggcttacactctcgaccagactgatgctgcttctggag tacctcatgaaacatttatacgacgccccacagacgctgctgcagcagatcgagtggaac ctcgtagtggccacgggcctggcccggccgtcggcggagaccactcttggcgaagtcgga accggctccgacgccggcccgccgaagacgcggatttactgcgaagtgcccttcgtcgag cagacctaccggaggctgtcccaggacgagacctcgatgagacccaagttctacgcgctg accgacaccaaagtcaacaaccaggagaatcccaagttcgacggcctggcctgcaacttc gtgctcggcactccgcacaagttaaagtatccggtgctggtggacgccctcctggccctg ctcaactgcgcctgcgtctgcgacggtcggggcgatcgcaccgcagtggccgctcgcgcc gcggcgcactactgcttccagaccgcttggaggctcgtgacgagcatgcccccggccact ccgcacgtggacaaactgcaggccgggacggcggccgacctgccttcgcctctgccgctg tacgccctggtgtgggctccccgcgccgacgccaagaaggcgttcaacccctggctcaag gatgcgctcgtcaaacagggcatgtacacgcagtacgccgaaaaccttctggccggagta agctcgtcctgcgataacatcaaatactcggcctggctggcctcggagaccattaagcac ctgaaagagaacctccgagacggactcccggctctcctcgacgtgatatcttgcgacgcg gcgttgatgcgcctcaacgtgtgcctggcggaaacttcctccgcggccgaggcccacccc ttcgtgccgcatctgctgagactgctggagaccgtcctggcgtgttgcaggtcgagcgcg agcctggaggcgggcgggtccgcgggggcggcgacggaggtgttgctgagcgtgtgcggc ggcggaccgagcgcgggcgccgcctccccgccccgactggggccggcgctgaaggcgctg ctgccgagcgacgtggctgcgctgctcgactcccgctcggcggatccggtgagcctggcg ctcttctactcgcgatccgaacgcctcctccgggtggcgcctcgcacgcgctttacgacc gccgtcgtttcgcaggcttcgtcggtcgcgccgtccgagggcgccgtgctcgagctggtg tccgcgcactgcgagctgatgagcgacaggcccgcgtacggcgtcgggccctctctgacg atgctggctcgctcggccgccaaactcctggaggtcggcgcggccgagatcgccgatagc ctcgagctgacgaggaggacgctggcgctcattgtccccgctctgaccgacggacgcctc gagttcctggcggagccgttgacggccactctgaactcgatcgtgccgcaggccgtgaag gcggaggagatcatacacgagcacatcctgcggaccacgtacccggcgctgtgcgactac gacgcctccgcggaggggatgctcgtgcacatcgtgaagtattgggagaagatactggat cgtcaggccggtcgcgccgcctacgaggcggtcttcgtcgaaggggacggcgagttcgtg ctcgggagaatccttctgtcggcgcccaacaccagcaatcctttcaccgatcgcgtcgtc aagctgttcattaagatatttgcgggctgcgaaacggaagacgtgagccaaagtctgtgc gtcggcgtgtgcaagttcatcggcgtcgccgaccgacagagcttgttcgaccttctcggc cacatctgcatttacggaccgtctctcgcgacggtcggcaccgcgaacggcagtcccacg gagacggaactcccgactccgacgtgctcagcgcccgaaggccatcccgcctcgctcgcc ttgcgcaacgccatccgctgcgtgctcttccgcaccgacggcgatgccgccccgcgcccg gacgctcgcaacgatcgggacctgccagtcttcgacaatcctgtcgcggcgactccggct ccgggggctcaatcggagacgaacgcccaacaatccggaaattcagagacgtgcagctgg tcggactgcagcaaagacagcgcgggggccaccggtgcgggcgtgggggagtcccgcgcc gaagcaagttcgcccgtgggtgagggcacccatgccgcccttctcacggctctctgcaaa cacgtcgtcttgcactgcgaagaggaagcgagcgagcggatgctggtgaccctgatcgaa gtgagcggcgaaggctgtcctcctccactgcttcgagaaatgtgccgcctcgcggactcg cactcgggcacgctgcacgagctactctttccggccgcgctggcgtggctgtcctcctgc gtcgaaagtctcagcagccccgaggtgctggagaagttagaggagggcacgatcgacaac gacaagacgtcgccgcagatagagtccgcgtgtacgctgctgtcgtacttgggagacgcc ttgcacgctatcggcgctccgccctcgcacgcgtggcgatcggtcagcccgacgtgggaa tctccttccgacctcggctttgacttggactacgccgacgaacagcaagacgacgacgat acgagcgccgacgattccgacgaggacgcggtgctgaccaacaagctgtgtaccttcacg ataacgcaacgcgagttcatgaaccagcactggtaccactgccacacgtgcaagatggtg gacggcgtcggagtatgcacggtctgcgcgagggtgtgccaccgcggtcacgacatctcc tacgccaagttcggaaacttcttctgcgactgcggagccaagccggacttcagctgccaa gccttggtgaagcgcgagaagtcttcgggcggcggccgcaccgccgaagaggcgccaccg gcgccgtccctgcgtcgtcgcccctccagccccacgcccgccgccctgctggccccaccc aggaggcctgtgctggctcataacattcagggttgccggagcttcctggcgagctacggg aagtgggagtggtgcctcgagcgcgtgcgcacgctgctttgcgcgctggcgggccccgtg cgcgccgcgtgcgagcggacggccgcggtcggagcgcacggccgagcgcagagggcgctg gcgcaactccatctgggcgagaagaagttctcgcacacggactcgctcatgctgccaacc ctaggttctcaagaaggcgcgttcgaaaacgtgcgaatgtcgtacacgggagagaacggc cagaccatcagacagttgatatcggctcacaagctgcgtcgcgtggccatgtgctgcttg gcttcgccgcagggccgaaggcaacacctcgccgtctcgcacgagaaaggcaaaataacg gtactccagctgtcggcccttctcaaacaagcggactcgtcgaagcacaggctgaccttg acccggctgtcttcagccccgatcccgttcaccgtgctcagcctaagcgggaacgcggcc aacgaagacctcttggccgtgtgcggactcaaagagtgccacgtgcttaccttcaactct ggcggagccgtggcggatcatctggtgttgacgaccgacctggaggcgaacaactacata attaaagccatctggctgccgggctcccagacgcagctcgcgctcgtcacgtcgaacttc gtcaagatattcgatctcagcaaggacctcgacagtccctcgcattacttcctcgtgccc agcggaaaggtccgcgacgtgacgttcgtgaaccaagagggagtgatgaacatgctctgc atgagctcggccggtcacatctactggcagccgctgagcgaggagtctcgggcaaccctc ggcaccttctacgtcaccaacaccttggaagtgttgcacccggagatacaggacgtcgcg ggattggtaggcggaggtggagtttcgatctactactcgcacactctgaagatgctcttc ttctcgtacgctcagggaaagagctttctcgccccgctcaactcggtcgaagagagcgtc aaaggcaccgccatgatcacggtgtacggcggaggcggtggccccaaggagggcggccgc ggcaagggcggcgcccagtctctgctgcagtgggccgaagtgcccggacacccgggcctg ctcacggctctgatgcaggcctccaacaaccccgtcgtgctcatgctcacgccgtccggc attcacgtgcaagagatcaaggtcgttccggccaaggcgaagattaccgacatggtggcc gtgcgccactggtgtggccccggcgagcagaagagcacgctgatcctgctgtgcgaggac ggcagtctgcgcatgtacgccgccgaccccgcccggacgggcttctggctctcaggtgcc gtgcagcccgtgcacgcgccgcgcaggcgcgcccgtcccgcgaggccctcgcacgcgcac gccgtcccccgaaagcagcaccagccgacgccgaagacgagcgacggcgctccccagttc ccgatagacttcttcgagcactgtcatgagatgagggacgccgagttcggcggcaacgac ctcctgcaggtgtacaacacggcgcagatcaagcatcggctaaacaccaccggcctctac gtcgtgtcgaccaagatgagcggtttcacaatggaagtcaccaactccgaccccaactcg gtcgtgtgcggaattcgagtcctgctcggcagccaggacgtcgccaggacgcctacatac atcgaaatatacggaagggcagtcccgactatggtggttcgcaatcgatggttcgacgtt cctctctcgagagaagagtcgctgcaatccgacaaaaaactctgcatcgtcttcggtccc tcgcaagatccggacggcgtcaccatggtggattccgtcaagatctacggaaagaacaag gagcaattcggttggccggaggagaacgaggacccggccgcctgtccgtcttccggcaga gttcctcaggaaaccgagggcgcggcgggcagcgccgacgggcccggcgccgtggagcgt ctggcatgctcggctctcgaggcgctggagctgagcgccggcacggccgtccgaccggca gtcgccgccggggccgacgcggccgcggacgccgccgagggcctgctgtgtgtgcccgct tcgccggcgctgcacgcgagagcccagtgcctcctgcgcgccgtctaccagggcgactat catcagcgcaaggaccgggccgtgctgcggtacgtgtgcgcctccctccgagagctgcgc gacgcgacggacgctcgcaacgtggaccccgaggcgtacttccgcctggtgctcctcgcc cgctctgtggccgtcgcgcgtccgcacaacctggttcgattcacggcgccaacgcccgag aagcccgccgacggcgactggtccgccctgtggaagggagacgggtcgggcgacgagccg cacgcgtgcgttctgctcgcgagcgtgctctggaagttggcggcctgcaagagccaggcg cgaggccctcccggcattctgtcttacggcttgaggcacgctgagcacacgttgcacgcc ctggccgacataattcacgcgttccaacttaactccgacccggaatgtgtcgaattcgga aatcaaatctatctgtcgctcctcctcgccgaagaccagaacatcagcttcggcgcgaag gcggctctcgtgcgagtgctgcgacctcgggtgaagaggcgacgcgtctacattccgtct ccaccgaacacacccggagccggctcgtcgacgaacgcggctcgcgcgagcggctcggcg tccgaggtcgcggcttcggagcccgaactcggcgctcggcgggaacctcgatacgtggac gtcgacgactcgctcgaaccgatggtgctgctggcgcccgacggaggtctcgaggcgctg ctggacattccggccgacgcggacgacgagacaatggtggagctggccatcgcgctgtcg ctgcaggagcaggaacagccacggagacagcagccgcacacgccaacggcgccgccgccg cccgcgcccggcttcagcgacgccaacgcctcgcccaacggctcggacgacgaaggcagc acggcggcgacggacggcagcaccctgcggacgtcgccggccgaggccgctgggtcggcc ggcgaggagagcgggggttccggcgccgacagcatcggcggagtgtccggccgcagcagc gtctatgctgggccttcgacttcgtcgtcgcagccggtggcgtccacgtcccgtggcctc gaggcggagagcgagacgcgcaagctgcacgcgctgcgcctgtctctgctgtccgcagcg ctggacgctctgccgaccctcaggaacttaccgggagtcagagccattccgttcgtgcaa gtggtgctgatgctagccggcgacttggattcgagcgtcgaaggggacagagcgctcctg gatctcctgctggaggttctgatcggcgagttggacattcagagcgaggagccctccggc gaagatcgtgacgcgagacgtgacttccagttggccatcgcgaggttggagactctggtc tcagaaccggagtccgcggacgaaagcgtcccgcccatctacgagaggactaatcgcaga gagctgcagctcgtcatcatgagactgctgagcgtgctcatgagccggtggaagacgtgc gggtcccgggagcacgcgcctagcgcgtcgtgcgctgcccacgtgtcgcgattggccgcg gccgccttcgtgcgcgccggcgcccctggccactgctacggcgtgctggctgcgctgctt ccctattggcggcagaagaacaacagcaacgcggccgcctcgactccgacgcgacagctt ctcaaacctcaaccgccgcagccgctgcccgacatgcagccgttcttcgtcaaggagtat gtcaagagtcacgtgctggacgtattcgataactacccgcagcttttgatggaaatggct gttcgccttccgtaccagatccacaagcactgtgatccgtcgcattttgattctcgctgg cgcactcttctctgcgagtacatgatgaatcctcagacgccgctcaggaaacaagtccgc aagctcctgctgctcctgtgcgacactcgagaacgctatcgtcagattcgcgacgtgcac gcgctcgacacacacctgaacgccgcgcgggcgctgctcgccacggatcccgcctacgac aagctcgtgcggctcatggagcatctcaaggcgtgcgtggagattgtgacccctcgcacg ggcaattggcagcacgcgtgccgctcggagcggcgcgagaccttgccgtggctgctgggc gcggcaaggcgcctgcacccgcacgtggcgcccaccgttctgcagctgctgcaggcggcg ctgtgcccgcccggcgctcagcccgcgcacgccgcccaaccgaaccaggccggcgccaaa gatgccaaggcgcagcccgagtggccaaaacgcgagcgcagcgccgacagcgacggctac gtgtcggacgcctccaagtttcaagagcagagagtgcccgacctcgtggcccagatacac aaacaggtgtctcaggaagaactgaaacttttcgtgaaggccttccttctggagaccaat tcgactgcggttcgttggcaagcgcacgccttgctgttggccatttacaacaactcgtct ccgaataaacaagcatctctggtcacgctgctttggagtctgtggcccacgctgccgcag tacggacgcaaggcggcgcaattcgtcgacctgctcggctacttcacgctcaagacctcc aaggtggacggctcggagtacatcggcagcgcggtggacctcctgcgcaaccagaaccgt ctgttgacgtcccacgggaactcggctctgtacgcgtctctgggagcgtacgtggagctc gagggatactacctggagtcggagccctgtctcgtgtgcaacaacccggaagtgcccatg gccaccatcaagctgcccactataaagatcgactccaagttcacaaccacgacgcagatc gtgaagctcgtgagcagccacacgatcagccgcatcagcctgcgcgtcggagacatcaag cggagcaagatggtgcgcggcatcaacttctactacaacaaccgcaccgtgcaggccgtg caagagctcaagaacaaacccggcatgtggcacaaggccaagcgcgtccagctgcaatcc ggacagaccgaagtgcgggtggacttcccgctgccgatagtcgcctgtaacctcatgatg gagtacgccgacttctacgagaaccagcaggccaccggagaatctcttcagtgtcctcgc tgctcgcagtcggtgcctgccaatcccggggtgtgcgccaattgcggcgaaaacgtcttc cagtgtcacaagtgccgggcaattaactatgacgagaaggatccgttcctgtgtcacgcg tgcggcttctgcaagtacgccaagttcgattacactctgatcgcgagaccttgctgcgtc gtcgattccatcgagaacgacgaggagcggaagaagaccgtgcaaacaataggcactctg ttggacaaggccgaccgcgtctaccgccagctgatcgccaacaagccccacttggagtcg ctcgtgcacaagataagcgagcaccgcgtggacggtcgaccggacgagaacagcaacacg gcgaccgcgaccttaggagggggtcaggtcaaccgcgtcattcaggccctcgcccacaag tactgcgtcgagagcaaggggcacttcgaggacctctccaagatcatccagaaggtgctg gcctgcaggaaggaattggttgcgtacgacaaagctcagagcgaacgacaaaacggcgag gcgtcgcccgcgtactccgtcctcgcgcagaactacgacggcgatctcgccaaggagagc ggcggctcgtgctacgggtgctcgctgtgcacggcggagcactgtctgaccctgctgcgg gccctggcgtcgcagccggacaagagagcggccctgtgcggcgccggcctcgtgcacgag ctcgtgcatcacaatctgcatcgcggcacgccgcagagccaggaagaggtgcgcgccttg atctgcctggtgacgcgtgacaacttggcggcgacggaacgcctgtgcactttgctgacg cagcgcatcactctgtcgctcgtggggcacgccgcctcgcaggaccacaacaactccgtg cggcccctggttctactcctgggatcgctggtcaaagtacaggactcgatcgaatgttgg gaggtgaggctccgctgcgtcgtgaagctgtgggtctggtgctgcccgaaagtgagcgaa gtggccgggatcccgccggccgcccactacatcctcaaggacgaagctttggccgacatg cccggcatcaacacctgctcgcccaactctcaccaattcgccctccaacaagtggccctg ccttgcctgcgctacatgcaagagctgatggctccgctcgctgcctcgccgtcccccgcc ccgtccgccctctccgccgcggcctccgcgacggacgaccgagtcgaggaagtcaaggag ggagacgagccgccgaatcgaacgggcgacctcgtcgtcgacctggcggcgtggctggcc ggccgagtatcgcagaaagagtggcgcagcctggccgcgccggaagcctcgccgcccgcc gactgcgagttgccgtcgagagacctgcgcctggcccgcgagtgcgtcggccggtggagg cgccgggtgctgctcggccgcggcatgcggcgcgtcagcttgtccgacggcagctggctg cggcccgtcatgttcgaccccagctcacgcatcgcgagagacacggcctgccgggtcgtc gcttcgctctgcgactcctacgagcggaccaaggcggtgctgatactgctgacgagcttc ctgcccgaggtgggcgctgcgggggaggcgagcgagcagttccttcagctgtatcagcgt ctagccgcgaagagcccgtggaagcagttcctggcgctgcggggcgtgctgcagcagata gcggatctcatgactgacgagatcgagcagctgcaccgcctcgaagagaccacgctcacc tcggacctcgctcaaggatacgctcttcagcgtctcacggagttgttggcgatgttcctg gaggagccgggggctcggagggcgtacaaaggccggctggtgggagcggttctcgggggc tacctctctctgcgtaggctggtagtgcagaggacgcgcctcaccgacgacacgcaggag aagctgttggagctgctcgaggagatgaccactggcaccgaagcggagacggccgagttc atggcggtgtgcatagagaccgtgcagaagtacccgctgcacgattaccgcactccggtg ttcatcttcgaacggctctgctccatcatctacccggaagaaaacgacgtcggcgaattc ttcctcactctggagaaagatccgcagcaggaggacttcttgcagggccgcatgttgggc aacccgtattcgtcaggagagccgggcatggggcctctgatgcgtgatgtcaaaaacaaa atctgcacggactgcgagctcgtggctctgctcgaagacgacaacggcatggagttgctc gtctgcaataagatcatgtccctggacttgcccgtgaaggatgtctacaagaaggtgtgg tgcacgtcgggagagagtctggacgcgatgcgcgtcgtttaccgtatgagaggacttctt ggagacgccaccgaagagttcgtggagacgctcagccagaccaacgccgaagccgtcgac gacgaacagacgtaccgcatggccaacgtgctggcggactgcggcggcctggaggcgatg ctgcgtcgcttggcggcgattcagcgagtgggcggtgcgcgggccctcgtgtccacgctg ctgcgcctgctgagcctctgcgtgcgcgtgcgccgctgcgtacgcgtgttgacgagcacg gacacgcgcgccctgcccgtcctcttgcacgcgctcacgctcgccgctgccgaggagaag gacatgcctagggccgagctcgtgcatcaactgctcgagataatggagcgcatactcacc gtggcggccagcgagagcttggagtcgttcctgcaattctcgctgacgttcggtggaccg gaacacgtgcaggccctgctcaactgtaccgaactgacagccatccgcaacaattccgtg tctctcggccacctgatgcgcgttctggccgcgttggtgtacggcaacgacctgaagatg gcgatgctggtggagcatttcaagccggcgctggagttcgagcgcctcgacgccgagcag tggggcgagcgcgagttccgcatcgagctgttctgcgcgctctgcgccaacgtcgagaga aacagcgtcggaggcacgctcaaagactacctgatctcgctcggcgtcgtccgcgacgcc ttggactacatagtgagacacgcgccgtgcgtgaaaccgacgctggtctgcaccgactcg gacgagctgaaggagttcataagtcgtccggctctgaagttcatcctgcggttcctcacg ggcctggcctccgaccacgaaccgactcagatgctggtgtgcgagaaggcgatcccgata gtgcatcggctcgagcaggtgtcctccggggaacacgtgggctccctggccgaaaacctt cttgaggcgctccggtcgcagccgcagtgcgccgacagggtgcggcaagtgcgggagttc accagacaggagaagaagcgcctcgccatggcggtccgcgagcggcagctgggggcgctg ggcatgcgcagcaacgagcgagggcaggtgacggcgcagtgctcgctcacgcagcaggtg gccgacctggccgaggaggccggcgccgtgtgctgcatttgccgcgagggatacaagtac cagcccacgaaggtgctgggcgtctacacctacacgaagcgctgccccgtggaggaggcg gaggcgcgcgcgcgcaagaccctcgggttcacgacggtctcgcactataacatcgtccac gtcgagtgccacatggctgccgtgaggctgcagcgggccagggacgaatgggagagcgcc gctctgcagaacgccagcactcgctgcaacggcctgctgccgctgtggggacccaacgtg cccgagtcggccttcgccagctgcctcgcccgacacaccacctacctgcaggagtgcacg ggccaccgcgacatcggctaccagtgcacggtgcacgacctgaagctgctcgcgtggcgc ttcgctcgcggtcgcacgttccacgacgacaccggtggcggaggtccgctctccaacatg cagctgctgccggcgctgctgcacatggcgctctatgtcatgaacaccacccgcatggcg gctcgcgaggccaacgccgtggacgagttcctgtcctggacgccggtcaagcgcctcgag tcggcccacgaggcggagggcgccctctactacgcgacgctcgcgctcctggtctgcccg cccgccgagtggaggcgcaaccgcgtggaggtgctgcggcggctgctgatcacggggcag gcgcggagcgtatcgggcggcgtgcagctgcacgcgctgacgcccgagtggcgcgtcccg aggccctgggccgacctcaaggccttcgccgtgttcgccgccctcgtcgaccagctctac ggggtcatgttcaagaacgtgtcggcggccaccgcggagcagtggcccgtgaagctggcg gagtacatccgagtgagcgacgaggcgaacgcgaaggccgccgagcgcatcgtggcgacg ctcaccgaggagctgctgccctgcacttccttcgccgagttctgtgacgcggccggcctc ctcgaggacgtccccgacccggacgcgttcctgtcgactctcttcgacgagctctga

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