KEGG   Physeter macrocephalus (sperm whale): 102974165
Entry
102974165         CDS       T06011                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pcad  Physeter macrocephalus (sperm whale)
Pathway
pcad00562  Inositol phosphate metabolism
pcad01100  Metabolic pathways
pcad04015  Rap1 signaling pathway
pcad04020  Calcium signaling pathway
pcad04022  cGMP-PKG signaling pathway
pcad04062  Chemokine signaling pathway
pcad04070  Phosphatidylinositol signaling system
pcad04071  Sphingolipid signaling pathway
pcad04072  Phospholipase D signaling pathway
pcad04081  Hormone signaling
pcad04082  Neuroactive ligand signaling
pcad04261  Adrenergic signaling in cardiomyocytes
pcad04270  Vascular smooth muscle contraction
pcad04310  Wnt signaling pathway
pcad04371  Apelin signaling pathway
pcad04540  Gap junction
pcad04611  Platelet activation
pcad04613  Neutrophil extracellular trap formation
pcad04621  NOD-like receptor signaling pathway
pcad04713  Circadian entrainment
pcad04720  Long-term potentiation
pcad04723  Retrograde endocannabinoid signaling
pcad04724  Glutamatergic synapse
pcad04725  Cholinergic synapse
pcad04726  Serotonergic synapse
pcad04728  Dopaminergic synapse
pcad04730  Long-term depression
pcad04742  Taste transduction
pcad04750  Inflammatory mediator regulation of TRP channels
pcad04911  Insulin secretion
pcad04912  GnRH signaling pathway
pcad04915  Estrogen signaling pathway
pcad04916  Melanogenesis
pcad04918  Thyroid hormone synthesis
pcad04919  Thyroid hormone signaling pathway
pcad04921  Oxytocin signaling pathway
pcad04922  Glucagon signaling pathway
pcad04924  Renin secretion
pcad04925  Aldosterone synthesis and secretion
pcad04926  Relaxin signaling pathway
pcad04927  Cortisol synthesis and secretion
pcad04928  Parathyroid hormone synthesis, secretion and action
pcad04929  GnRH secretion
pcad04933  AGE-RAGE signaling pathway in diabetic complications
pcad04934  Cushing syndrome
pcad04935  Growth hormone synthesis, secretion and action
pcad04961  Endocrine and other factor-regulated calcium reabsorption
pcad04970  Salivary secretion
pcad04971  Gastric acid secretion
pcad04972  Pancreatic secretion
pcad04973  Carbohydrate digestion and absorption
pcad05010  Alzheimer disease
pcad05016  Huntington disease
pcad05017  Spinocerebellar ataxia
pcad05022  Pathways of neurodegeneration - multiple diseases
pcad05142  Chagas disease
pcad05143  African trypanosomiasis
pcad05146  Amoebiasis
pcad05163  Human cytomegalovirus infection
pcad05200  Pathways in cancer
pcad05415  Diabetic cardiomyopathy
pcad05417  Lipid and atherosclerosis
Module
pcad_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pcad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102974165 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102974165 (PLCB3)
   04310 Wnt signaling pathway
    102974165 (PLCB3)
   04371 Apelin signaling pathway
    102974165 (PLCB3)
   04020 Calcium signaling pathway
    102974165 (PLCB3)
   04070 Phosphatidylinositol signaling system
    102974165 (PLCB3)
   04072 Phospholipase D signaling pathway
    102974165 (PLCB3)
   04071 Sphingolipid signaling pathway
    102974165 (PLCB3)
   04022 cGMP-PKG signaling pathway
    102974165 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    102974165 (PLCB3)
   04081 Hormone signaling
    102974165 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102974165 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102974165 (PLCB3)
   04613 Neutrophil extracellular trap formation
    102974165 (PLCB3)
   04621 NOD-like receptor signaling pathway
    102974165 (PLCB3)
   04062 Chemokine signaling pathway
    102974165 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    102974165 (PLCB3)
   04922 Glucagon signaling pathway
    102974165 (PLCB3)
   04929 GnRH secretion
    102974165 (PLCB3)
   04912 GnRH signaling pathway
    102974165 (PLCB3)
   04915 Estrogen signaling pathway
    102974165 (PLCB3)
   04921 Oxytocin signaling pathway
    102974165 (PLCB3)
   04926 Relaxin signaling pathway
    102974165 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    102974165 (PLCB3)
   04918 Thyroid hormone synthesis
    102974165 (PLCB3)
   04919 Thyroid hormone signaling pathway
    102974165 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    102974165 (PLCB3)
   04916 Melanogenesis
    102974165 (PLCB3)
   04924 Renin secretion
    102974165 (PLCB3)
   04925 Aldosterone synthesis and secretion
    102974165 (PLCB3)
   04927 Cortisol synthesis and secretion
    102974165 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102974165 (PLCB3)
   04270 Vascular smooth muscle contraction
    102974165 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    102974165 (PLCB3)
   04971 Gastric acid secretion
    102974165 (PLCB3)
   04972 Pancreatic secretion
    102974165 (PLCB3)
   04973 Carbohydrate digestion and absorption
    102974165 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    102974165 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    102974165 (PLCB3)
   04725 Cholinergic synapse
    102974165 (PLCB3)
   04728 Dopaminergic synapse
    102974165 (PLCB3)
   04726 Serotonergic synapse
    102974165 (PLCB3)
   04720 Long-term potentiation
    102974165 (PLCB3)
   04730 Long-term depression
    102974165 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    102974165 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    102974165 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    102974165 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102974165 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102974165 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    102974165 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102974165 (PLCB3)
   05142 Chagas disease
    102974165 (PLCB3)
   05143 African trypanosomiasis
    102974165 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102974165 (PLCB3)
   05016 Huntington disease
    102974165 (PLCB3)
   05017 Spinocerebellar ataxia
    102974165 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    102974165 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102974165 (PLCB3)
   05415 Diabetic cardiomyopathy
    102974165 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102974165 (PLCB3)
   04934 Cushing syndrome
    102974165 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcad04131]
    102974165 (PLCB3)
Enzymes [BR:pcad01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102974165 (PLCB3)
Membrane trafficking [BR:pcad04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102974165 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102974165 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 102974165
NCBI-ProteinID: XP_023989129
Ensembl: ENSPCTG00005014619
UniProt: A0A2Y9TJZ7
LinkDB
Position
Unknown
AA seq 1230 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSQNLVTLRVDPSGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLITVVAGPDPVNTSFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCCSIFGDALLIDPLDKYPLAPGVALPSPQDLMGRILVKNKKRHRPSSGVPDS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPVLSNGEEAGLEKPSLEPQKSLAE
ESLQRGPDALGSAYREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANAVRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRVLPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPETSQETQSQQP
GSQLSPNPTPSPLDASPRRPPGPVTSPASTSLSSPGQRDDLIASVLSEVAPAPLDELRGH
KALVKLQSRQERDFRELHKKHQRKAVALTRRLLDNLAQAQAESRCRHRPGVLGGEDEREE
EEEVKRYQEFQKKQVQCLLELREAQADTEAERRLEHLRQAQQRLREIVMDAHTTQFKRLK
EMNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRQERLVAAQQQILQQLTEEEPKLLAQLAQECQEQRERLPQEIRWSLLGETPEGLGDGHL
VACASNGHAPGSSGHLSGADSESQEETTKL
NT seq 3693 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccatgcgctgcagctggagccgcccaccgtcgtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcagaacctg
gtaactctgcgcgtggaccccagtggcttcttcctatactggacaggacccaacatggag
gtggacacactggacatcagttccatcagggacacgaggacaggccgttatgcccgccta
cccaaggaccccaagattcgggaggtgctgggctttgggggccctgatgcccggttggag
gagaagctgataacagtggtggccgggccagacccggtgaatacatccttcttgaacttc
atggccgtgcaggatgacacagccaaggtctggtccgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcttgcgcaaagcgtacacgaagctg
aaactgcaggtgaaccaggatggacggatcccggtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtagaaactgcgctggaatcctgtggcctcaatttcaaccggagc
gagtccatccggcctgacgagttttccttggaaatcttcgagcggttcttgaacaagctt
tgtctgcggccggacattgacaagatcctgctggagataggcgccaagggcaaaccatac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaat
gaagtgctgtacccgcctctgcggccctcccaggcccggctgcttatcgagaagtatgaa
cccaaccagcaattcctggagagagaccagatgtccatggagggcttcagccgctacctg
ggaggtgaggagaacggcatcctgcccctagaggccctggatctgagcgcagacatgacc
cagccgctcagtgcctacttcatcaactcctcacacaacacctatctcactgcggggcag
ctggcgggaacctcgtcggtggagatgtaccggcaggcactgctgtggggctgccgctgc
gtggagctggacgtgtggaaagggcggccgcctgaggaggagcccttcattacccacggc
ttcaccatgaccacggaggtgccgctgcgagatgtgctggaggccattgcggagaccgcc
ttcaagacctcgccctaccccgtcatcctctcctttgagaaccatgtggactcggcaaag
cagcaggccaagatggctgagtactgctgctccatctttggggatgcgctgctcatcgac
cccctggacaagtacccgctggccccgggcgtcgccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcggcaccggcccagcagtggcgttcctgacagc
tccgtgcgcaagcggccgctagagcagagcaactcggccctgagcgagagctccgctgcc
accgagccctcctcgccccagcttgggtcccccagctctgacagctgcccagtcctgagc
aatggggaggaggcgggccttgagaagcccagcctggagcctcagaagtctctggctgag
gagagcttgcagcggggccccgatgctcttggatctgcctaccgtgaggatgaggaagag
gatgaggaagaggaggaacagacggaccccaaaaagccgaccaccgacgagggcactgcc
agcagtgaggtcaatgccaccgaggaaatgtcgacacttgtcaactacatcgagcccgtc
aagttcaagtcctttgaggctgctcgaaagaggaacaagtgctttgagatgtcatccttt
gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacacgcgtggactcgtccaactacatg
ccccagctcttctggaacgtgggctgccagctcgtcgcgctcaacttccagaccctggac
gtggccatgcagctcaacgcgggcgtgttcgagtacaacgggcgcagtggctacctactc
aagcccgagttcatgcggcggccggacaagtcctttgaccccttcaccgaggtcatcgtg
gatggcatcgtggccaatgccgtgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggatatgttcggcctccctgtcgacacgcggcgc
aagtaccgcactcggacctctcaggggaactcgttcaaccccgtgtgggatgaggagccc
ttcgacttccccaaggtggtgctgcccacgctggcttcgctgcgcatcgcggcctttgag
gagggtggcaagttcgtggggcaccgggtcctgcctgtctctgccatccgctcagggtac
cactacatctgcctgcggaacgaggccaaccagccgctgtgcctgccggccctgctcatc
tacactgaggcctctgactacatccccgatgaccaccaggactacgcagaggccctgatc
aatcccatcaagcacgtcagcctgatggaccagagggccaagcagctggccgccctcatt
ggggagagtgaggctcaggctggcccggagacaagccaggagacccagtctcagcagcca
gggtcccagctgagcccaaaccccacacccagcccactggacgcctccccccgccggccc
ccaggccccgtcacctcccccgccagcacctccctcagcagcccaggtcagcgcgatgac
ctcattgccagcgtcctctcagaggtggccccggccccgctggatgagctccgaggccac
aaggccctggtgaagctccagagccggcaagagcgagactttcgagagctgcacaagaag
catcagcggaaggcggttgccctcacacgccggttgcttgacaacctggcccaggcccag
gccgagagcaggtgccggcaccggccgggtgtcctaggcggggaggacgagagggaggag
gaggaagaggtgaagaggtatcaagagttccaaaagaaacaggtgcagtgtctgctggag
ctgagggaggcccaggcggacacagaggccgagcggaggctggagcacctgagacaggct
cagcagaggctcagggagattgtcatggatgctcacaccactcagttcaagagactgaag
gagatgaacgagagggagaagaaggaactgcagaagatcctggacagaaagcgccacaac
agtatctcagaggcaaagaccagggagaaacataagaaggaggcggaactgacagagatt
aaccgtcggcacatcactgagtcagtcaactccatccgtcggctggaggaggcccagaag
cagcggcaggaacgccttgtggccgcgcagcagcagattctccaacagctgacagaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgggagaggctgccc
caggagatccgctggagcctgctgggcgagacgccggagggactgggggacgggcatctg
gtggcctgtgccagcaatggtcacgcgcctgggagcagtgggcacctgtccggcgctgat
tcggagagccaagaggagactacgaagctctga

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