Physeter macrocephalus (sperm whale): 102974888 Help Entry 102974888         CDS       T06011                                  Symbol PRKCA Name (RefSeq) protein kinase C alpha type   KO K02677   classical protein kinase C alpha type [EC:2.7.11.13] Organism pcad  Physeter macrocephalus (sperm whale) Pathway pcad01521   EGFR tyrosine kinase inhibitor resistance pcad04010   MAPK signaling pathway pcad04012   ErbB signaling pathway pcad04014   Ras signaling pathway pcad04015   Rap1 signaling pathway pcad04020   Calcium signaling pathway pcad04066   HIF-1 signaling pathway pcad04070   Phosphatidylinositol signaling system pcad04071   Sphingolipid signaling pathway pcad04072   Phospholipase D signaling pathway pcad04082   Neuroactive ligand signaling pcad04150   mTOR signaling pathway pcad04151   PI3K-Akt signaling pathway pcad04261   Adrenergic signaling in cardiomyocytes pcad04270   Vascular smooth muscle contraction pcad04310   Wnt signaling pathway pcad04360   Axon guidance pcad04370   VEGF signaling pathway pcad04510   Focal adhesion pcad04540   Gap junction pcad04613   Neutrophil extracellular trap formation pcad04650   Natural killer cell mediated cytotoxicity pcad04664   Fc epsilon RI signaling pathway pcad04666   Fc gamma R-mediated phagocytosis pcad04670   Leukocyte transendothelial migration pcad04713   Circadian entrainment pcad04720   Long-term potentiation pcad04723   Retrograde endocannabinoid signaling pcad04724   Glutamatergic synapse pcad04725   Cholinergic synapse pcad04726   Serotonergic synapse pcad04727   GABAergic synapse pcad04728   Dopaminergic synapse pcad04730   Long-term depression pcad04750   Inflammatory mediator regulation of TRP channels pcad04911   Insulin secretion pcad04912   GnRH signaling pathway pcad04916   Melanogenesis pcad04918   Thyroid hormone synthesis pcad04919   Thyroid hormone signaling pathway pcad04921   Oxytocin signaling pathway pcad04925   Aldosterone synthesis and secretion pcad04926   Relaxin signaling pathway pcad04928   Parathyroid hormone synthesis, secretion and action pcad04929   GnRH secretion pcad04933   AGE-RAGE signaling pathway in diabetic complications pcad04935   Growth hormone synthesis, secretion and action pcad04960   Aldosterone-regulated sodium reabsorption pcad04961   Endocrine and other factor-regulated calcium reabsorption pcad04970   Salivary secretion pcad04971   Gastric acid secretion pcad04972   Pancreatic secretion pcad05017   Spinocerebellar ataxia pcad05022   Pathways of neurodegeneration - multiple diseases pcad05031   Amphetamine addiction pcad05032   Morphine addiction pcad05143   African trypanosomiasis pcad05146   Amoebiasis pcad05161   Hepatitis B pcad05163   Human cytomegalovirus infection pcad05164   Influenza A pcad05170   Human immunodeficiency virus 1 infection pcad05171   Coronavirus disease - COVID-19 pcad05200   Pathways in cancer pcad05205   Proteoglycans in cancer pcad05206   MicroRNAs in cancer pcad05207   Chemical carcinogenesis - receptor activation pcad05214   Glioma pcad05223   Non-small cell lung cancer pcad05225   Hepatocellular carcinoma pcad05231   Choline metabolism in cancer pcad05415   Diabetic cardiomyopathy pcad05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:pcad00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102974888 (PRKCA)    04012 ErbB signaling pathway     102974888 (PRKCA)    04014 Ras signaling pathway     102974888 (PRKCA)    04015 Rap1 signaling pathway     102974888 (PRKCA)    04310 Wnt signaling pathway     102974888 (PRKCA)    04370 VEGF signaling pathway     102974888 (PRKCA)    04066 HIF-1 signaling pathway     102974888 (PRKCA)    04020 Calcium signaling pathway     102974888 (PRKCA)    04070 Phosphatidylinositol signaling system     102974888 (PRKCA)    04072 Phospholipase D signaling pathway     102974888 (PRKCA)    04071 Sphingolipid signaling pathway     102974888 (PRKCA)    04151 PI3K-Akt signaling pathway     102974888 (PRKCA)    04150 mTOR signaling pathway     102974888 (PRKCA)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     102974888 (PRKCA)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     102974888 (PRKCA)    04540 Gap junction     102974888 (PRKCA)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     102974888 (PRKCA)    04650 Natural killer cell mediated cytotoxicity     102974888 (PRKCA)    04664 Fc epsilon RI signaling pathway     102974888 (PRKCA)    04666 Fc gamma R-mediated phagocytosis     102974888 (PRKCA)    04670 Leukocyte transendothelial migration     102974888 (PRKCA)   09152 Endocrine system    04911 Insulin secretion     102974888 (PRKCA)    04929 GnRH secretion     102974888 (PRKCA)    04912 GnRH signaling pathway     102974888 (PRKCA)    04921 Oxytocin signaling pathway     102974888 (PRKCA)    04926 Relaxin signaling pathway     102974888 (PRKCA)    04935 Growth hormone synthesis, secretion and action     102974888 (PRKCA)    04918 Thyroid hormone synthesis     102974888 (PRKCA)    04919 Thyroid hormone signaling pathway     102974888 (PRKCA)    04928 Parathyroid hormone synthesis, secretion and action     102974888 (PRKCA)    04916 Melanogenesis     102974888 (PRKCA)    04925 Aldosterone synthesis and secretion     102974888 (PRKCA)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     102974888 (PRKCA)    04270 Vascular smooth muscle contraction     102974888 (PRKCA)   09154 Digestive system    04970 Salivary secretion     102974888 (PRKCA)    04971 Gastric acid secretion     102974888 (PRKCA)    04972 Pancreatic secretion     102974888 (PRKCA)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     102974888 (PRKCA)    04961 Endocrine and other factor-regulated calcium reabsorption     102974888 (PRKCA)   09156 Nervous system    04724 Glutamatergic synapse     102974888 (PRKCA)    04727 GABAergic synapse     102974888 (PRKCA)    04725 Cholinergic synapse     102974888 (PRKCA)    04728 Dopaminergic synapse     102974888 (PRKCA)    04726 Serotonergic synapse     102974888 (PRKCA)    04720 Long-term potentiation     102974888 (PRKCA)    04730 Long-term depression     102974888 (PRKCA)    04723 Retrograde endocannabinoid signaling     102974888 (PRKCA)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     102974888 (PRKCA)   09158 Development and regeneration    04360 Axon guidance     102974888 (PRKCA)   09159 Environmental adaptation    04713 Circadian entrainment     102974888 (PRKCA)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102974888 (PRKCA)    05206 MicroRNAs in cancer     102974888 (PRKCA)    05205 Proteoglycans in cancer     102974888 (PRKCA)    05207 Chemical carcinogenesis - receptor activation     102974888 (PRKCA)    05231 Choline metabolism in cancer     102974888 (PRKCA)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     102974888 (PRKCA)    05214 Glioma     102974888 (PRKCA)    05223 Non-small cell lung cancer     102974888 (PRKCA)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102974888 (PRKCA)    05161 Hepatitis B     102974888 (PRKCA)    05171 Coronavirus disease - COVID-19     102974888 (PRKCA)    05164 Influenza A     102974888 (PRKCA)    05163 Human cytomegalovirus infection     102974888 (PRKCA)   09174 Infectious disease: parasitic    05146 Amoebiasis     102974888 (PRKCA)    05143 African trypanosomiasis     102974888 (PRKCA)   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     102974888 (PRKCA)    05022 Pathways of neurodegeneration - multiple diseases     102974888 (PRKCA)   09165 Substance dependence    05031 Amphetamine addiction     102974888 (PRKCA)    05032 Morphine addiction     102974888 (PRKCA)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102974888 (PRKCA)    05415 Diabetic cardiomyopathy     102974888 (PRKCA)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102974888 (PRKCA)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102974888 (PRKCA)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pcad01001]     102974888 (PRKCA)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pcad04131]     102974888 (PRKCA) Enzymes [BR:pcad01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.13  protein kinase C      102974888 (PRKCA) Protein kinases [BR:pcad01001]  Serine/threonine kinases: AGC group   PKC family [OT]    102974888 (PRKCA) Membrane trafficking [BR:pcad04131]  Endocytosis   Lipid raft mediated endocytosis    Caveolin-mediated endocytosis     102974888 (PRKCA) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr C2 C1_1 Pkinase_C ABC1 DUF4656 Kinase-like Motif Other DBs NCBI-GeneID:  102974888 NCBI-ProteinID:  XP_054945789 UniProt:  A0A9W2X2W7 LinkDB All DBs Position 14:132228116..132531707 Genome browser AA seq 600 aa AA seqDB search MADIFPANDSAAPQDVANRFARKGALRQKNVHEVKDHRFIARFFKQPTFCSHCTDFIWGF GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDVSSLETIIFLRDAKNLIPMDPNGL SDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTT RNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLG PAGHKVISPEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKK DVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQV GKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDG VTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME HNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHTFFRRIDWEKLENREIQP PFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPTLQSTV NT seq 1803 nt NT seq  +upstreamnt  +downstreamnt atggctgacatcttcccggccaacgactcggcggcgcctcaggacgtggccaaccgcttc gcccgcaaaggggcgctgagacagaagaacgtacacgaggtgaaggaccaccgcttcatc gcccgcttcttcaagcagcccaccttttgcagccactgcaccgactttatctgggggttt gggaaacaaggcttccagtgccaagtttgctgtttcgtggttcacaagaggtgccatgaa tttgttactttttcttgtccgggtgcggataaaggacctgacactgatgtaagtagcctg gaaactattattttcttacgagatgcaaaaaatctcatccctatggatccaaatgggctt tcagatccttatgtgaagctgaagcttattcctgaccccaagaacgaaagcaaacaaaaa accaaaaccatccgttccacactgaacccccagtggaatgagtcctttacgttcaaatta aaaccttcagataaagaccgacggctgtccgtagagatctgggactgggatcggacaacc aggaacgacttcatggggtccctttccttcggagtctcggagctgatgaagatgccggcc agtggatggtacaagctgctgaaccaagaggaaggtgagtactacaatgtacccattcca gaaggtgatgaagaaggcaacatggagctcaggcagaaattcgagaaagccaagctcggc cctgctggccacaaagtcattagtcctgaggacaggagacagccttccaacaacctcgac agagtgaaactcaccgacttcaacttcctcatggtgctgggcaagggtagcttcgggaag gtgatgcttgcggacaggaaggggaccgaggagctgtacgccatcaagatcctgaagaag gacgtggtgatccaggatgacgatgtggagtgcaccatggtggagaagcgggtgctggcc ctgctggacaagcccccgttcctgacgcagctgcactcctgcttccagacggtggatcgg ctgtacttcgtcatggaatacgtcaatggcggggacctcatgtaccacatccagcaagta ggaaaatttaaggaaccgcaagcagtgttctacgcagcagagatttccatcgggttgttc tttcttcataaaagaggaatcatttatagagacctgaagttagataacgtcatgctggat tcggaaggacatatcaagatcgcggactttgggatgtgtaaggagcacatgatggatggg gtcacgaccaggaccttctgtgggaccccggattacatcgccccggagataatcgcttat cagccgtatgggaaatccgtggactggtgggcctacggcgtcctgttatatgaaatgctg gccgggcagcctccgtttgacggcgaggatgaggatgaactgtttcagtccatcatggag cacaacgtctcgtacccgaagtccttgtccaaggaggccgtttccatctgcaaagggctg atgaccaaacaccctggcaagcggctgggctgcgggcccgagggagagcgggacgtgcgg gaacacaccttcttccggaggatcgactgggagaagctggagaacagggagatccagccg cccttcaagcccaaagtgtgcggcaaaggagcagaaaactttgacaagttcttcacgcga gggcagcctgtcttaacgccacccgatcagctggtcatcgctaacatcgaccagtctgac ttcgaagggttctcatatgtcaacccccagttcgtgcaccccaccctgcagagcacagta tga

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