Physeter macrocephalus (sperm whale): 102975467
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Entry
102975467 CDS
T06011
Symbol
EGFR
Name
(RefSeq) epidermal growth factor receptor isoform X1
KO
K04361
epidermal growth factor receptor [EC:
2.7.10.1
]
Organism
pcad
Physeter macrocephalus (sperm whale)
Pathway
pcad01521
EGFR tyrosine kinase inhibitor resistance
pcad01522
Endocrine resistance
pcad03272
Virion - Hepatitis viruses
pcad04010
MAPK signaling pathway
pcad04012
ErbB signaling pathway
pcad04014
Ras signaling pathway
pcad04015
Rap1 signaling pathway
pcad04020
Calcium signaling pathway
pcad04066
HIF-1 signaling pathway
pcad04068
FoxO signaling pathway
pcad04072
Phospholipase D signaling pathway
pcad04144
Endocytosis
pcad04151
PI3K-Akt signaling pathway
pcad04510
Focal adhesion
pcad04520
Adherens junction
pcad04540
Gap junction
pcad04630
JAK-STAT signaling pathway
pcad04810
Regulation of actin cytoskeleton
pcad04912
GnRH signaling pathway
pcad04915
Estrogen signaling pathway
pcad04921
Oxytocin signaling pathway
pcad04926
Relaxin signaling pathway
pcad04928
Parathyroid hormone synthesis, secretion and action
pcad04934
Cushing syndrome
pcad05160
Hepatitis C
pcad05163
Human cytomegalovirus infection
pcad05165
Human papillomavirus infection
pcad05171
Coronavirus disease - COVID-19
pcad05200
Pathways in cancer
pcad05205
Proteoglycans in cancer
pcad05206
MicroRNAs in cancer
pcad05207
Chemical carcinogenesis - receptor activation
pcad05208
Chemical carcinogenesis - reactive oxygen species
pcad05210
Colorectal cancer
pcad05212
Pancreatic cancer
pcad05213
Endometrial cancer
pcad05214
Glioma
pcad05215
Prostate cancer
pcad05218
Melanoma
pcad05219
Bladder cancer
pcad05223
Non-small cell lung cancer
pcad05224
Breast cancer
pcad05225
Hepatocellular carcinoma
pcad05226
Gastric cancer
pcad05230
Central carbon metabolism in cancer
pcad05231
Choline metabolism in cancer
pcad05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
pcad00001
]
09120 Genetic Information Processing
09125 Information processing in viruses
03272 Virion - Hepatitis viruses
102975467 (EGFR)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
102975467 (EGFR)
04012 ErbB signaling pathway
102975467 (EGFR)
04014 Ras signaling pathway
102975467 (EGFR)
04015 Rap1 signaling pathway
102975467 (EGFR)
04630 JAK-STAT signaling pathway
102975467 (EGFR)
04066 HIF-1 signaling pathway
102975467 (EGFR)
04068 FoxO signaling pathway
102975467 (EGFR)
04020 Calcium signaling pathway
102975467 (EGFR)
04072 Phospholipase D signaling pathway
102975467 (EGFR)
04151 PI3K-Akt signaling pathway
102975467 (EGFR)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
102975467 (EGFR)
09144 Cellular community - eukaryotes
04510 Focal adhesion
102975467 (EGFR)
04520 Adherens junction
102975467 (EGFR)
04540 Gap junction
102975467 (EGFR)
09142 Cell motility
04810 Regulation of actin cytoskeleton
102975467 (EGFR)
09150 Organismal Systems
09152 Endocrine system
04912 GnRH signaling pathway
102975467 (EGFR)
04915 Estrogen signaling pathway
102975467 (EGFR)
04921 Oxytocin signaling pathway
102975467 (EGFR)
04926 Relaxin signaling pathway
102975467 (EGFR)
04928 Parathyroid hormone synthesis, secretion and action
102975467 (EGFR)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102975467 (EGFR)
05206 MicroRNAs in cancer
102975467 (EGFR)
05205 Proteoglycans in cancer
102975467 (EGFR)
05207 Chemical carcinogenesis - receptor activation
102975467 (EGFR)
05208 Chemical carcinogenesis - reactive oxygen species
102975467 (EGFR)
05230 Central carbon metabolism in cancer
102975467 (EGFR)
05231 Choline metabolism in cancer
102975467 (EGFR)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
102975467 (EGFR)
09162 Cancer: specific types
05210 Colorectal cancer
102975467 (EGFR)
05212 Pancreatic cancer
102975467 (EGFR)
05225 Hepatocellular carcinoma
102975467 (EGFR)
05226 Gastric cancer
102975467 (EGFR)
05214 Glioma
102975467 (EGFR)
05218 Melanoma
102975467 (EGFR)
05219 Bladder cancer
102975467 (EGFR)
05215 Prostate cancer
102975467 (EGFR)
05213 Endometrial cancer
102975467 (EGFR)
05224 Breast cancer
102975467 (EGFR)
05223 Non-small cell lung cancer
102975467 (EGFR)
09172 Infectious disease: viral
05160 Hepatitis C
102975467 (EGFR)
05171 Coronavirus disease - COVID-19
102975467 (EGFR)
05163 Human cytomegalovirus infection
102975467 (EGFR)
05165 Human papillomavirus infection
102975467 (EGFR)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
102975467 (EGFR)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
102975467 (EGFR)
01522 Endocrine resistance
102975467 (EGFR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pcad01001
]
102975467 (EGFR)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
pcad04147
]
102975467 (EGFR)
Enzymes [BR:
pcad01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
102975467 (EGFR)
Protein kinases [BR:
pcad01001
]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
102975467 (EGFR)
Exosome [BR:
pcad04147
]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
102975467 (EGFR)
Exosomal proteins of pancreatic cancer cells
102975467 (EGFR)
Exosomal proteins of bladder cancer cells
102975467 (EGFR)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
GF_recep_IV
Pkinase
Furin-like
TM_ErbB1
Kinase-like
Borrelia_P83
ABC1
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
102975467
NCBI-ProteinID:
XP_023970904
Ensembl:
ENSPCTG00005001100
UniProt:
A0A2Y9S4T3
LinkDB
All DBs
Position
5:complement(102672987..102879229)
Genome browser
AA seq
1209 aa
AA seq
DB search
MRRSEAGRAVLLALLAAHFQASPALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYMQSSYDLSFLKTIQEVAGYVLIALNTAEKIPLEKLQIIRGNVLYESTHALA
VLSNYGANKTGLRELPMRNLQEILQGAVRFRNNPVLCNMGTVQWRDIVNTDFLSNMSMEF
QDQLGRCPKCDPVCLNGSCWGAGKENCQKLTKVICAQQCSGRCRGRSPSDCCHSQCAAGC
TGPRESDCLVCRRFRDGATCKDTCPPLMLYDPTTYEMKVNPLGKYSFGATCVRKCPRNYV
VTDHGSCVRACSSDSQEVEEDGVRKCKKCDGPCGKVCNGIGIGEFKDTLSINATNIKHFR
NCTSISGDLHILPVAFRGDSFTRTPPLDPKELDILKTVKEITGFLLIQAWPANRTGLHAF
ENLEIIRGRTKQHGQFSLAVVGLDIMSLGLRSLKEISDGDVIISGNRKLCYADTINWRKL
FGTSSQKTKIINNRSEKECKAMGHVCNPLCSSEGCWGPKPKDCVSCRNFSRGKECVEKCN
ILKGEPREFVENSECVQCHPECLPQAMNVTCTGHGPGSCVKCAHNIDGPHCVKTCPAGVT
GENSTLIWKYADANHVCHLCHPSCTYGCAGPGLEGCAVNGPRIPSIATGIVGALLLAVVL
ALGVGLFLRRRRIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETELKKVKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGV
CLTSTVQLITQLMPFGCLLDYVREHRDSIGSQHLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISTVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQ
QGFFHSPTTSRTPLLSSLSAASNTPTVACVDRNGQSYPLKEDSFLQRYSSDPTGALTEDS
IDDAFLPAPEYVNQSIPKRPAGSVQNPVYHNQPLNPAPGREPHYQNSHGNAVDSPEYLSA
AHPACTNGVLDGPALWAQKGGHQISLDNPAYQQAFLPKEAKSNGIFKGPAAENAEYLRAA
PAGSDLTGA
NT seq
3630 nt
NT seq
+upstream
nt +downstream
nt
atgcgacgctccgaggcgggccgcgccgtgctcctggcgctgctggccgcgcacttccag
gcgagtccggcgctggaggagaagaaagtttgccaagggacaagtaacaagctcacccag
ttgggcacttttgaagaccactttctgagcctccagaggatgttcaataactgtgaggtg
gtccttgggaatttggaaattacctacatgcaaagtagttacgacctttctttcctaaag
accatccaggaggttgctggctatgtactcattgccctcaacacagcggagaagattcct
ctggaaaagctgcagatcatcagaggaaatgtgctctatgaaagcacccatgccctagcg
gtcttatccaactacggtgcaaataaaacgggactgagggagttgcccatgagaaactta
caggagatcctgcaaggcgccgtgcggttcaggaacaaccctgtcctctgcaacatgggg
accgtccagtggagggacatcgtcaacaccgactttctgagcaacatgtcgatggaattt
caggaccagctgggcagatgcccaaagtgtgatccagtctgtcttaatggaagctgctgg
ggtgcggggaaagagaactgccagaaactgaccaaagtcatctgtgcccagcagtgttcc
gggcgctgccgcggcaggtcccccagcgactgctgccacagccagtgtgccgccggctgc
acggggccgcgggagagtgactgcctggtctgccgcaggttccgggacggagccacgtgc
aaggacacatgcccgccactcatgctgtacgaccccaccacctacgagatgaaagtcaac
ccgctggggaagtacagcttcggcgccacctgtgtcaggaagtgcccccgtaactacgtg
gtgacggaccacggctcgtgcgtccgcgcctgcagctctgacagccaggaggtggaggag
gacggcgtccgcaagtgtaaaaagtgcgacggaccttgtggcaaagtttgtaacgggata
ggaattggtgagtttaaagatacactttccataaatgctacaaatattaaacacttcaga
aattgcacctcgatcagtggagaccttcatatcctgccagtagcatttaggggtgattcc
ttcacccgtactccacctctggacccaaaggaactggacattctaaaaactgtaaaggaa
ataacagggtttttgctgattcaggcctggcctgcaaacaggactggcctccatgctttt
gagaacctggaaatcatacgtggcaggacaaagcaacatggtcagttttctcttgcggtt
gttggcctggatataatgtccttgggattacgctccctcaaggagataagtgatggagat
gtgatcatttcaggaaaccgaaagttgtgctacgcagatacaataaactggagaaaactc
tttgggacctcaagtcagaaaaccaaaatcataaacaacaggagtgaaaaagagtgcaag
gccatgggccacgtctgtaaccctctgtgctcgtcagagggctgctggggcccgaaaccc
aaagactgcgtgtcctgccgaaacttcagccgtggcaaggagtgtgtggagaagtgcaac
attctaaagggagagcccagggagttcgttgagaactccgagtgcgtgcagtgccatccg
gaatgcctgccccaagccatgaacgtgacctgcacgggacacggaccaggcagctgtgta
aagtgtgcccacaacatcgacggccctcactgcgtcaagacctgccctgctggagtcaca
ggagaaaacagcaccctgatctggaagtatgcagatgccaatcacgtgtgtcacctgtgc
caccccagctgcacctacggctgtgctgggccaggtcttgaaggctgtgcagtgaatggg
cccaggattccgtccatcgccaccgggatcgtgggcgccctgctgctggctgtggtgctg
gccctgggcgtcggcctctttctgcgcaggcgccgcatcgtccgcaagcgcacgctgcgc
cggctgctgcaggagcgcgagcttgtcgagcctctgacgcccagcggagaagctcccaac
caagctctcttgaggatcttaaaggagacggaattaaaaaaggtcaaggtgctgggctcc
ggagccttcggcacggtgtacaagggactctggatcccagaaggcgagaaggttaaaatt
cctgtggctatcaaggaattaagagaagccacatctccaaaagccaacaaggagattctt
gatgaagcctacgtgatggccagcgtggacaatcctcacgtgtgccgccttctgggcgtc
tgcctgacgtccacggtacagctcatcacccagctcatgcccttcggctgcctgctggac
tatgtccgtgagcacagagacagcatcggctcccagcacctgctcaactggtgcgtgcag
atcgcaaagggcatgaactacctggaggaccggcgcttggtgcaccgagacctggcggcc
aggaatgtgctggtgaagacgccgcagcacgtcaagatcacagacttcgggctggccaaa
ctgctgggcgccgaggagaaggagtaccacgcagaagggggcaaagtgcctatcaagtgg
atggctttggaatccattttacaccgaatttatacccaccagagtgatgtctggagctac
ggagtcaccgtttgggagttgatgacctttgggtccaagccttacgacgggatccccgcg
agtgagatctcaaccgtcctggagaagggagaacgcctgcctcagccgcccatctgcacc
atcgacgtctacatgatcatggtcaagtgctggatgattgatgcagagagtcgcccaaag
ttccgtgagttgatcattgaattctccaaaatggcccgagacccccagcgctaccttgtc
atccagggggacgagaggatgcatctgcccagccctacagactccaacttctaccgcgcc
ctgatggacgaagaggacatggaggatgtcgtggatgccgatgagtacctcatcccccag
cagggcttcttccacagccccaccacttcccggacgcccctcctcagttctctgagcgcc
gccagcaacactcccactgtggcttgcgttgatagaaacgggcagagctatcccctcaag
gaagatagcttcttgcagcggtacagctcagaccccactggcgccttgaccgaggatagc
atagatgacgccttccttccagcgcccgaatacgtaaaccagtccattcccaaaaggccc
gcgggctctgtccagaaccccgtctatcacaatcagcctctgaacccggctccaggcaga
gagcctcactaccagaattcccacggcaatgccgtcgacagccccgagtatctcagcgcc
gcccaccccgcctgcaccaacggtgtgctcgacggccctgccctctgggcgcagaagggc
ggccaccagattagcctggacaaccctgcctaccagcaggccttccttcccaaggaagcc
aagtcaaacggcatctttaagggtcctgccgctgaaaatgcagaatacctgagggcagca
ccagcaggcagtgaccttactggggcctga
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