KEGG   Physeter macrocephalus (sperm whale): 102976706
Entry
102976706         CDS       T06011                                 
Symbol
IKBKB
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
pcad  Physeter macrocephalus (sperm whale)
Pathway
pcad01523  Antifolate resistance
pcad04010  MAPK signaling pathway
pcad04014  Ras signaling pathway
pcad04062  Chemokine signaling pathway
pcad04064  NF-kappa B signaling pathway
pcad04068  FoxO signaling pathway
pcad04150  mTOR signaling pathway
pcad04151  PI3K-Akt signaling pathway
pcad04210  Apoptosis
pcad04380  Osteoclast differentiation
pcad04620  Toll-like receptor signaling pathway
pcad04621  NOD-like receptor signaling pathway
pcad04622  RIG-I-like receptor signaling pathway
pcad04623  Cytosolic DNA-sensing pathway
pcad04625  C-type lectin receptor signaling pathway
pcad04657  IL-17 signaling pathway
pcad04658  Th1 and Th2 cell differentiation
pcad04659  Th17 cell differentiation
pcad04660  T cell receptor signaling pathway
pcad04662  B cell receptor signaling pathway
pcad04668  TNF signaling pathway
pcad04722  Neurotrophin signaling pathway
pcad04910  Insulin signaling pathway
pcad04920  Adipocytokine signaling pathway
pcad04930  Type II diabetes mellitus
pcad04931  Insulin resistance
pcad04932  Non-alcoholic fatty liver disease
pcad04936  Alcoholic liver disease
pcad05010  Alzheimer disease
pcad05132  Salmonella infection
pcad05135  Yersinia infection
pcad05142  Chagas disease
pcad05145  Toxoplasmosis
pcad05160  Hepatitis C
pcad05161  Hepatitis B
pcad05162  Measles
pcad05163  Human cytomegalovirus infection
pcad05164  Influenza A
pcad05165  Human papillomavirus infection
pcad05166  Human T-cell leukemia virus 1 infection
pcad05167  Kaposi sarcoma-associated herpesvirus infection
pcad05168  Herpes simplex virus 1 infection
pcad05169  Epstein-Barr virus infection
pcad05170  Human immunodeficiency virus 1 infection
pcad05171  Coronavirus disease - COVID-19
pcad05200  Pathways in cancer
pcad05206  MicroRNAs in cancer
pcad05208  Chemical carcinogenesis - reactive oxygen species
pcad05212  Pancreatic cancer
pcad05215  Prostate cancer
pcad05220  Chronic myeloid leukemia
pcad05221  Acute myeloid leukemia
pcad05222  Small cell lung cancer
pcad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcad05417  Lipid and atherosclerosis
pcad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102976706 (IKBKB)
   04014 Ras signaling pathway
    102976706 (IKBKB)
   04064 NF-kappa B signaling pathway
    102976706 (IKBKB)
   04668 TNF signaling pathway
    102976706 (IKBKB)
   04068 FoxO signaling pathway
    102976706 (IKBKB)
   04151 PI3K-Akt signaling pathway
    102976706 (IKBKB)
   04150 mTOR signaling pathway
    102976706 (IKBKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    102976706 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    102976706 (IKBKB)
   04621 NOD-like receptor signaling pathway
    102976706 (IKBKB)
   04622 RIG-I-like receptor signaling pathway
    102976706 (IKBKB)
   04623 Cytosolic DNA-sensing pathway
    102976706 (IKBKB)
   04625 C-type lectin receptor signaling pathway
    102976706 (IKBKB)
   04660 T cell receptor signaling pathway
    102976706 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    102976706 (IKBKB)
   04659 Th17 cell differentiation
    102976706 (IKBKB)
   04657 IL-17 signaling pathway
    102976706 (IKBKB)
   04662 B cell receptor signaling pathway
    102976706 (IKBKB)
   04062 Chemokine signaling pathway
    102976706 (IKBKB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102976706 (IKBKB)
   04920 Adipocytokine signaling pathway
    102976706 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102976706 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102976706 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102976706 (IKBKB)
   05206 MicroRNAs in cancer
    102976706 (IKBKB)
   05208 Chemical carcinogenesis - reactive oxygen species
    102976706 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102976706 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    102976706 (IKBKB)
   05221 Acute myeloid leukemia
    102976706 (IKBKB)
   05220 Chronic myeloid leukemia
    102976706 (IKBKB)
   05215 Prostate cancer
    102976706 (IKBKB)
   05222 Small cell lung cancer
    102976706 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102976706 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    102976706 (IKBKB)
   05161 Hepatitis B
    102976706 (IKBKB)
   05160 Hepatitis C
    102976706 (IKBKB)
   05171 Coronavirus disease - COVID-19
    102976706 (IKBKB)
   05164 Influenza A
    102976706 (IKBKB)
   05162 Measles
    102976706 (IKBKB)
   05168 Herpes simplex virus 1 infection
    102976706 (IKBKB)
   05163 Human cytomegalovirus infection
    102976706 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102976706 (IKBKB)
   05169 Epstein-Barr virus infection
    102976706 (IKBKB)
   05165 Human papillomavirus infection
    102976706 (IKBKB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102976706 (IKBKB)
   05135 Yersinia infection
    102976706 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102976706 (IKBKB)
   05142 Chagas disease
    102976706 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102976706 (IKBKB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102976706 (IKBKB)
   05418 Fluid shear stress and atherosclerosis
    102976706 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102976706 (IKBKB)
   04936 Alcoholic liver disease
    102976706 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    102976706 (IKBKB)
   04931 Insulin resistance
    102976706 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    102976706 (IKBKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcad01001]
    102976706 (IKBKB)
Enzymes [BR:pcad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     102976706 (IKBKB)
Protein kinases [BR:pcad01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   102976706 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin YrbL-PhoP_reg APH
Other DBs
NCBI-GeneID: 102976706
NCBI-ProteinID: XP_028341955
Ensembl: ENSPCTG00005017974
UniProt: A0A455AZ89
LinkDB
Position
Unknown
AA seq 771 aa
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLNGAVKFSSSLPHPSNLNSVLAQRLEKWLQLMLMWHPRQRGTDPIYGPNGCF
KALDDILNLKLVHVLNMVTGTIHTYPVAEDESLPSLKARIQQDTGIPEEDQELLQEAGLA
LTPDKPAAQCTSDGKLNEGRTLDMDLVFLFDNSRVAYETQISPRPQPESVSCILQEPKRS
LPFFQLRKVWGQVWHSIQALKEDCGRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQKEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL
QTDIVDLQRSPLGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMGEDEKTVVRLQEKRQKELWNLLKV
ACSKVRGPVSGSPDSMNTSRLSHPSQLLSQPCPAPDSLPEAVKKSEDLVAEAHALCAQLE
NALQDTMKEQDQSLRVMARGSPRCSTPFLPTANEKKQIERWCRASSISVYT
NT seq 2316 nt   +upstreamnt  +downstreamnt
atgagctggtcaccttccctgccaacccagacatgcggggcctgggaaatgaaagaacgg
cttgggacagggggatttgggaacgtcatccgatggcataaccaggaaacgggcgagcag
atcgctatcaagcagtgccggcaggagcttagtccccggaaccgcgagcgctggtgcctg
gagatccagatcatgaggaggctgaaccaccccaacgtggtggccgcccgggacgtccct
gagggcatgcagagcctggctcccaacgacctgcccctgctggccatggagtactgccag
ggaggggacctgcggaagtacctgaaccagtttgagaactgctgtggcctgcgggaagga
gccatcctcaccctgctgagcgacatcgcctctgcacttagataccttcacgaaaacagg
atcatccatcgggatctaaagccagaaaacatcgtcctgcagcaaggggaacagagattg
atacacaaaattattgacctaggatatgccaaggagctggaccagggtagtctgtgcact
tcctttgtggggaccctgcagtacctggcccctgagctgctagagcagcagaagtacacg
gtgaccgtggactactggagcttcggcaccttggccttcgagtgtatcacgggctttcgg
cccttcctgcccaactggcagcccgtgcagtggcactccaaagtccggcagaagagtgag
atggacatcgtggtgagtgaggacctgaacggagccgtgaagttctccagctcgttaccc
cacccgagcaacctcaacagcgtcctggcccagcggctggagaagtggctgcagctgatg
ctgatgtggcacccccgacagaggggcaccgaccccatctacgggcccaatggctgcttc
aaggccctggatgacatcttaaacttgaagctggttcacgtcttgaacatggtcacgggc
accattcacacctaccccgtggcagaggacgagagtctgcctagcttgaaggcccggatc
cagcaggacacaggcatccccgaggaggaccaggagctgctgcaggaagcgggtctggcc
ttgacccccgacaagcccgccgctcagtgcacctccgacggcaagctgaacgagggccgc
accctggacatggatctcgttttcctctttgacaacagcagggtcgcctatgagacccag
atctccccacggccccagcctgaaagcgtcagctgtatcttgcaagagcccaagaggagc
ctcccgttcttccagctgaggaaggtgtggggtcaggtctggcacagcatccaggccctg
aaggaggactgcggccgcctgcagcagggccagcgcgccgccatgatgaatctgctccgg
aacaacagctgcctctccaagatgaagaattccatggcctccatgtctcagcagctcaag
gccaagctggatttctttaaaaccagcatccagattgacctggagaagtacagcgagcag
aaggagtttgggatcacgtcagacaagctgctgctggcctggagggagatggagcaggcc
gtggagctctgtggacgggagaacgaggtgaagcacttggtggagcggatgatggcgctg
cagaccgacatcgtggacctgcagcgcagccccctgggccggaagcagggcgggacgctg
gacgacctagaagagcaggcgcgggagctttaccggaggctgagggagaagccccgagac
cagcgaactgacggcgacagtcaggaaatggtacggctgctcctgcaggcaatccaaggc
tttgagaagaaagtgcgagtgatctatacgcagctcagtaagactgtggtctgcaagcag
aaggccctggagctgctgcccaaggtggaggaggtggtgagcttaatgggcgaggatgag
aagactgtggttcggctgcaggagaagcgacagaaggagctctggaacctcctgaaggtc
gcttgtagcaaggtccgaggtcccgtcagcggaagtccggacagcatgaacacgtcccgc
ctgagtcaccccagccagctgctgtcgcagccttgcccagcccctgacagcttacccgag
gccgtcaagaagagcgaagacctcgtggctgaagcacacgccctgtgcgcgcagctggaa
aacgccctgcaggacaccatgaaggagcaggaccagagcttaagggtaatggcccgtggg
agcccccgctgctccacgcccttccttcctacagcaaacgagaaaaagcagatcgaaagg
tggtgccgtgcttcctcgatctcagtgtacacttag

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