KEGG   Physeter macrocephalus (sperm whale): 102977108
Entry
102977108         CDS       T06011                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pcad  Physeter macrocephalus (sperm whale)
Pathway
pcad00562  Inositol phosphate metabolism
pcad01100  Metabolic pathways
pcad01521  EGFR tyrosine kinase inhibitor resistance
pcad01522  Endocrine resistance
pcad01524  Platinum drug resistance
pcad04012  ErbB signaling pathway
pcad04014  Ras signaling pathway
pcad04015  Rap1 signaling pathway
pcad04024  cAMP signaling pathway
pcad04062  Chemokine signaling pathway
pcad04066  HIF-1 signaling pathway
pcad04068  FoxO signaling pathway
pcad04070  Phosphatidylinositol signaling system
pcad04071  Sphingolipid signaling pathway
pcad04072  Phospholipase D signaling pathway
pcad04081  Hormone signaling
pcad04140  Autophagy - animal
pcad04150  mTOR signaling pathway
pcad04151  PI3K-Akt signaling pathway
pcad04152  AMPK signaling pathway
pcad04210  Apoptosis
pcad04211  Longevity regulating pathway
pcad04213  Longevity regulating pathway - multiple species
pcad04218  Cellular senescence
pcad04360  Axon guidance
pcad04370  VEGF signaling pathway
pcad04380  Osteoclast differentiation
pcad04510  Focal adhesion
pcad04550  Signaling pathways regulating pluripotency of stem cells
pcad04611  Platelet activation
pcad04613  Neutrophil extracellular trap formation
pcad04620  Toll-like receptor signaling pathway
pcad04625  C-type lectin receptor signaling pathway
pcad04630  JAK-STAT signaling pathway
pcad04650  Natural killer cell mediated cytotoxicity
pcad04660  T cell receptor signaling pathway
pcad04662  B cell receptor signaling pathway
pcad04664  Fc epsilon RI signaling pathway
pcad04666  Fc gamma R-mediated phagocytosis
pcad04668  TNF signaling pathway
pcad04670  Leukocyte transendothelial migration
pcad04722  Neurotrophin signaling pathway
pcad04725  Cholinergic synapse
pcad04750  Inflammatory mediator regulation of TRP channels
pcad04810  Regulation of actin cytoskeleton
pcad04910  Insulin signaling pathway
pcad04914  Progesterone-mediated oocyte maturation
pcad04915  Estrogen signaling pathway
pcad04917  Prolactin signaling pathway
pcad04919  Thyroid hormone signaling pathway
pcad04923  Regulation of lipolysis in adipocytes
pcad04926  Relaxin signaling pathway
pcad04929  GnRH secretion
pcad04930  Type II diabetes mellitus
pcad04931  Insulin resistance
pcad04932  Non-alcoholic fatty liver disease
pcad04933  AGE-RAGE signaling pathway in diabetic complications
pcad04935  Growth hormone synthesis, secretion and action
pcad04960  Aldosterone-regulated sodium reabsorption
pcad04973  Carbohydrate digestion and absorption
pcad05010  Alzheimer disease
pcad05017  Spinocerebellar ataxia
pcad05020  Prion disease
pcad05100  Bacterial invasion of epithelial cells
pcad05132  Salmonella infection
pcad05135  Yersinia infection
pcad05142  Chagas disease
pcad05146  Amoebiasis
pcad05160  Hepatitis C
pcad05161  Hepatitis B
pcad05162  Measles
pcad05163  Human cytomegalovirus infection
pcad05164  Influenza A
pcad05165  Human papillomavirus infection
pcad05166  Human T-cell leukemia virus 1 infection
pcad05167  Kaposi sarcoma-associated herpesvirus infection
pcad05168  Herpes simplex virus 1 infection
pcad05169  Epstein-Barr virus infection
pcad05170  Human immunodeficiency virus 1 infection
pcad05171  Coronavirus disease - COVID-19
pcad05200  Pathways in cancer
pcad05203  Viral carcinogenesis
pcad05205  Proteoglycans in cancer
pcad05206  MicroRNAs in cancer
pcad05207  Chemical carcinogenesis - receptor activation
pcad05208  Chemical carcinogenesis - reactive oxygen species
pcad05210  Colorectal cancer
pcad05211  Renal cell carcinoma
pcad05212  Pancreatic cancer
pcad05213  Endometrial cancer
pcad05214  Glioma
pcad05215  Prostate cancer
pcad05218  Melanoma
pcad05220  Chronic myeloid leukemia
pcad05221  Acute myeloid leukemia
pcad05222  Small cell lung cancer
pcad05223  Non-small cell lung cancer
pcad05224  Breast cancer
pcad05225  Hepatocellular carcinoma
pcad05226  Gastric cancer
pcad05230  Central carbon metabolism in cancer
pcad05231  Choline metabolism in cancer
pcad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pcad05415  Diabetic cardiomyopathy
pcad05417  Lipid and atherosclerosis
pcad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pcad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102977108 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102977108 (PIK3CB)
   04014 Ras signaling pathway
    102977108 (PIK3CB)
   04015 Rap1 signaling pathway
    102977108 (PIK3CB)
   04370 VEGF signaling pathway
    102977108 (PIK3CB)
   04630 JAK-STAT signaling pathway
    102977108 (PIK3CB)
   04668 TNF signaling pathway
    102977108 (PIK3CB)
   04066 HIF-1 signaling pathway
    102977108 (PIK3CB)
   04068 FoxO signaling pathway
    102977108 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    102977108 (PIK3CB)
   04072 Phospholipase D signaling pathway
    102977108 (PIK3CB)
   04071 Sphingolipid signaling pathway
    102977108 (PIK3CB)
   04024 cAMP signaling pathway
    102977108 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    102977108 (PIK3CB)
   04152 AMPK signaling pathway
    102977108 (PIK3CB)
   04150 mTOR signaling pathway
    102977108 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102977108 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102977108 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    102977108 (PIK3CB)
   04218 Cellular senescence
    102977108 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102977108 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    102977108 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102977108 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102977108 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    102977108 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    102977108 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    102977108 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    102977108 (PIK3CB)
   04660 T cell receptor signaling pathway
    102977108 (PIK3CB)
   04662 B cell receptor signaling pathway
    102977108 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    102977108 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    102977108 (PIK3CB)
   04670 Leukocyte transendothelial migration
    102977108 (PIK3CB)
   04062 Chemokine signaling pathway
    102977108 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102977108 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    102977108 (PIK3CB)
   04929 GnRH secretion
    102977108 (PIK3CB)
   04915 Estrogen signaling pathway
    102977108 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    102977108 (PIK3CB)
   04917 Prolactin signaling pathway
    102977108 (PIK3CB)
   04926 Relaxin signaling pathway
    102977108 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    102977108 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    102977108 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102977108 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102977108 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    102977108 (PIK3CB)
   04722 Neurotrophin signaling pathway
    102977108 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102977108 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    102977108 (PIK3CB)
   04380 Osteoclast differentiation
    102977108 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    102977108 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    102977108 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102977108 (PIK3CB)
   05206 MicroRNAs in cancer
    102977108 (PIK3CB)
   05205 Proteoglycans in cancer
    102977108 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    102977108 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    102977108 (PIK3CB)
   05203 Viral carcinogenesis
    102977108 (PIK3CB)
   05230 Central carbon metabolism in cancer
    102977108 (PIK3CB)
   05231 Choline metabolism in cancer
    102977108 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102977108 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102977108 (PIK3CB)
   05212 Pancreatic cancer
    102977108 (PIK3CB)
   05225 Hepatocellular carcinoma
    102977108 (PIK3CB)
   05226 Gastric cancer
    102977108 (PIK3CB)
   05214 Glioma
    102977108 (PIK3CB)
   05221 Acute myeloid leukemia
    102977108 (PIK3CB)
   05220 Chronic myeloid leukemia
    102977108 (PIK3CB)
   05218 Melanoma
    102977108 (PIK3CB)
   05211 Renal cell carcinoma
    102977108 (PIK3CB)
   05215 Prostate cancer
    102977108 (PIK3CB)
   05213 Endometrial cancer
    102977108 (PIK3CB)
   05224 Breast cancer
    102977108 (PIK3CB)
   05222 Small cell lung cancer
    102977108 (PIK3CB)
   05223 Non-small cell lung cancer
    102977108 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102977108 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    102977108 (PIK3CB)
   05161 Hepatitis B
    102977108 (PIK3CB)
   05160 Hepatitis C
    102977108 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    102977108 (PIK3CB)
   05164 Influenza A
    102977108 (PIK3CB)
   05162 Measles
    102977108 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    102977108 (PIK3CB)
   05163 Human cytomegalovirus infection
    102977108 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102977108 (PIK3CB)
   05169 Epstein-Barr virus infection
    102977108 (PIK3CB)
   05165 Human papillomavirus infection
    102977108 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102977108 (PIK3CB)
   05135 Yersinia infection
    102977108 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    102977108 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102977108 (PIK3CB)
   05142 Chagas disease
    102977108 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102977108 (PIK3CB)
   05017 Spinocerebellar ataxia
    102977108 (PIK3CB)
   05020 Prion disease
    102977108 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102977108 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    102977108 (PIK3CB)
   05415 Diabetic cardiomyopathy
    102977108 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102977108 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    102977108 (PIK3CB)
   04931 Insulin resistance
    102977108 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102977108 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102977108 (PIK3CB)
   01524 Platinum drug resistance
    102977108 (PIK3CB)
   01522 Endocrine resistance
    102977108 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcad04131]
    102977108 (PIK3CB)
Enzymes [BR:pcad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102977108 (PIK3CB)
Membrane trafficking [BR:pcad04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102977108 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 Tom37_C
Other DBs
NCBI-GeneID: 102977108
NCBI-ProteinID: XP_023987639
Ensembl: ENSPCTG00005000147
UniProt: A0A2Y9TH96
LinkDB
Position
1:29492304..29695231
AA seq 1070 aa
MCYRFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATMSYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGRGLHEFDALKDPEVNEFRIKMRRFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGRLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKLYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKAI
NPSKYQTIRKSGKVDYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIRFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKALSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYIEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDHSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgctaccgcttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatgtcctatattaaacagatgttatgg
aaacaagttcataattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaagactctgt
gatgttagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggagaa
aaattagactcaaaaattggagtccttataggaagaggtctgcatgaatttgatgccttg
aaggatcctgaggtgaatgaattccgaataaaaatgcgcagattcagtgaggaaaagatt
cagtcgcttgtgggattgtcttggatggattggctaaagcaaacctatccaccagagcat
gaaccatccattcctgaaaatttagaagataaactttacggaggaaggctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagctttcaagtatctcctaatatgaatcct
atcaaaataaatgaattggcaatccaaaaacgtttgactattcatgggaaagaagatgaa
gttagcccctatgactatgtgttgcaagtcagtgggagagtagaatatgtgtttggtgat
cacccactaattcagttccagtatatccggaactgtgtaatgaataggaccttgccccat
tttatacttgtggaatgttgcaagatcaagaagctgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaattcatctaaccttcctcttcctttaccaccaaagaaaact
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaactgtaaaagttcatgtcagggctggcctttttcatggt
accgaactcctgtgtaaaaccgtcgtaagctcagagatatcagggaaaaatgatcatatt
tggaacgaaccactggaatttgatatcaatacttgtgacctgccacgaatggctcgatta
tgttttgctgtttatgcagttttggataaagtgaaaacaaagaaatcaactaaagctatt
aatccctctaaatatcagaccatcaggaaatctggaaaagtggattatcctgtagcctgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagatataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccgtatactgaaaatgcaacagctttgcacatcagattcccagagaataaaaaa
caaccttattactatcctccctttgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtatcaagtcgaggtggaaagaagtttcttgctgtactgaaagaa
atcttggacagggatccgttgtctcaactgtgtgagaatgaaatggatcttatttggact
ttgcgacaagactgcagagagaatttcccacagtcattgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcactacttcagatttggcctaaa
ctgcccccccgggaggccctggagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgtctgcaacagatgagtgatgaagaactctctcaatatctttta
cagttggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattccta
ctagaaagagcacttgctaatcggaggatagggcagtttttattttggcaccttaggtca
gaagtgcacattcctgctgtttcagtacaatttggtgtcatccttgaagcgtactgccgg
ggaagcgtaggtcacatgaaagcgctttccaagcaggttgaagcactcaataaattaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaatagagccaaagggaaagaa
gcaatgcacacttgtttaaaacagaatgcttatcgggaagccctctctgacctgcaatca
cctctgaacccatgtgttatcctctcagaactctatattgaaaagtgtaaatacatggat
tccaaaatgaagcctttgtggctggtgtacaacaacaaggtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacggcaggatatgttgacacttcaaatgctg
cgcttgatggatttactctggaaagaagctggtctggatcttaggatgctgccttatggc
tgtttagcaacaggagaccactctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgcagcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggag
tttaccctgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgataacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggagagagtgccttttattctt
acctatgatttcattcatgtaattcaacaaggaaaaacaggaaacacggaaaagtttggc
cggttccgccagtgttgtgaggatgcatatctgattttgcgacggcatgggaatctcttc
atcacgctctttgcactgatgttgactgcagggcttcctgagctcacgtcagtcaaggat
atacagtaccttaaggactctcttgccttagggaagagtgaagaagaagcactcaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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